Tuberculosis preventative therapy as part of a care package for people living with HIV in a district of Thailand.

We studied the risk factors for default in isoniazid preventative therapy (IPT) against tuberculosis in 412 people living with HIV (PLWH) in Mae Chan Hospital, Thailand. Default rates decreased from 57% in 1995 to 17% in 1999. Female sex, residence inside Mae Chan District, and registered in the PLWH group at enrollment of IPT were associated with lower default rates. The integration of IPT into the PLWH day care centre activities over the years might contribute to improvements.

[1]  H. Yanai,et al.  Prevalence of drug-resistant tuberculosis in an HIV endemic area in northern Thailand. , 2001, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[2]  G H Guyatt,et al.  Isoniazid prophylaxis for tuberculosis in HIV infection: a meta-analysis of randomized controlled trials. , 1999, AIDS.

[3]  M. Mwasekaga,et al.  Low levels of drug resistance amidst rapidly increasing tuberculosis and human immunodeficiency virus co-epidemics in Botswana. , 1999, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[4]  N. Binkin,et al.  Impact of HIV on tuberculosis in sub-Saharan Africa: a regional perspective. , 1997, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[5]  P. Sawanpanyalert,et al.  Adherence to tuberculosis preventive therapy among HIV‐infected persons in Chiang Rai, Thailand , 1997, AIDS.

[6]  P. Sawanpanyalert,et al.  Rapid increase in HIV-related tuberculosis, Chiang Rai, Thailand, 1990–1994 , 1996, AIDS.

[7]  D. McFarland,et al.  Preventive chemotherapy for HIV‐associated tuberculosis in Uganda: an operational assessment at a voluntary counselling and testing centre , 1995, AIDS.

[8]  J. Pape,et al.  Effect of isoniazid prophylaxis on incidence of active tuberculosis and progression of HIV infection , 1993, The Lancet.