Chondroid Syringoma With Extensive Ossification

specific antibodies: cytokeratin 8-18 (BioGenex, San Ramon, CA), cytokeratin AE1-AE3 (Dako, Glostrup, Denmark), S100 (Dako), and carcinoembryonic antigen (Dako). The histopathological examination revealed a lobulated nodule consisting of epithelial–myoepithelial islands with a tubuloglandular pattern, within a chondromyxoid stroma (Figure 1). Cytologic atypia, necrosis, or increased mitotic activity was not present. The lesion showed extensive ossification with a hypocellular bone marrow. The bone tissue seemed to be formed within areas of the chondral tissue by a process of enchondral ossification (Figure 2). Immunohistochemical stainings with cytokeratin 8-18, cytokeratin AE1-AE3, and carcinoembryonic antigen were positive in the epithelial cells; S100 was expressed in both stromal and epithelial components.