Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran.

A spiropyran photoswitch is activated using UV light and protons from a form that shows no interaction with DNA to a form that binds to DNA by intercalation. This scheme is interpreted as a biologically relevant logic AND gate with potential applications as a dually controlled anticancer drug.

[1]  David R Walt,et al.  Intelligent medical diagnostics via molecular logic. , 2009, Journal of the American Chemical Society.

[2]  Ying-Wei Yang,et al.  Dual-controlled nanoparticles exhibiting AND logic. , 2009, Journal of the American Chemical Society.

[3]  D. Hilvert,et al.  Kinetic characterization of spiropyrans in aqueous media. , 2009, Chemical communications.

[4]  E. Akkaya,et al.  Thinking outside the silicon box: molecular and logic as an additional layer of selectivity in singlet oxygen generation for photodynamic therapy. , 2009, Journal of the American Chemical Society.

[5]  Joakim Andréasson,et al.  Photoswitched DNA-binding of a photochromic spiropyran. , 2008, Journal of the American Chemical Society.

[6]  Joakim Andréasson,et al.  Molecular all-photonic encoder-decoder. , 2008, Journal of the American Chemical Society.

[7]  K. Szaciłowski.  Digital information processing in molecular systems. , 2008, Chemical reviews.

[8]  E. Katz,et al.  Biocomputing security system: concatenated enzyme-based logic gates operating as a biomolecular keypad lock. , 2008, Journal of the American Chemical Society.

[9]  J. Andréasson,et al.  A molecule-based 1: 2 Digital demultiplexer , 2007 .

[10]  Uwe Pischel,et al.  Chemical approaches to molecular logic elements for addition and subtraction. , 2007, Angewandte Chemie.

[11]  J. Andréasson,et al.  Molecular 2:1 digital multiplexer. , 2007, Angewandte Chemie.

[12]  Günter Mayer,et al.  Biologically active molecules with a "light switch". , 2006, Angewandte Chemie.

[13]  H. Taguchi,et al.  Semibiological molecular machine with an implemented "AND" logic gate for regulation of protein folding. , 2006, Journal of the American Chemical Society.

[14]  David Margulies,et al.  Fluorescein as a model molecular calculator with reset capability , 2005, Nature materials.

[15]  Richard A Lerner,et al.  Prodrug activation gated by a molecular "OR" logic trigger. , 2005, Angewandte Chemie.

[16]  A. P. de Silva,et al.  Molecular-scale logic gates. , 2004, Chemistry.

[17]  Trevor Yann,et al.  Molecular Logic: A Half-Subtractor Based on Tetraphenylporphyrin [J. Am. Chem. Soc. 2003, 125, 11198−11199]. , 2003 .

[18]  Trevor Yann,et al.  Molecular logic: a half-subtractor based on tetraphenylporphyrin. , 2003, Journal of the American Chemical Society.

[19]  Vincenzo Balzani,et al.  Molecular logic circuits. , 2003, Chemphyschem : a European journal of chemical physics and physical chemistry.

[20]  F. Raymo.  Digital processing and communication with molecular switches , 2002 .

[21]  P. Dervan,et al.  Molecular recognition of DNA by small molecules. , 2001, Bioorganic & medicinal chemistry.

[22]  D. Chadwick,et al.  The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity , 2001 .

[23]  A. P. D. S. and,et al.  Proof-of-Principle of Molecular-Scale Arithmetic , 2000 .

[24]  H. Rochefort,et al.  Characterization of very acidic phagosomes in breast cancer cells and their association with invasion. , 1994, Journal of cell science.

[25]  T. Kurucsev,et al.  Linear dichroism spectroscopy of nucleic acids , 1992, Quarterly Reviews of Biophysics.

[26]  I. Cameron,et al.  Intracellular concentration of sodium and other elements as related to mitogenesis and oncogenesis in vivo. , 1980, Cancer research.

[27]  B. Nordén,et al.  High-sensitivity linear dichroism as a tool for equilibrium analysis in biochemistry. Stability constant of DNA--ethidiumbromide complex. , 1976, Biophysical chemistry.

[28]  Uwe Pischel,et al.  Smart molecules at work--mimicking advanced logic operations. , 2010, Chemical Society reviews.

[29]  Juyoung Yoon,et al.  Chem Soc Rev , 2020 .