Synthesis of new functionalized calix[n]phyrin macrocycles with varied ring sizes by using a sterically congested dipyrromethane.

Congest and conjugate: The application of a sterically congested dipyrromethane in an acid-catalyzed [2+2+2] building-block approach was studied for the first time, resulting in the formation of two stable calix[6]phyrin(1.1.1.1.1.1) diastereomers (see scheme). The calix[n]phyrins were further functionalized at their pentafluorophenyl residues, allowing the first synthesis of a calix[4]phyrin(1.1.1.1) dimer.

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