Phase Separation Study of Imipramine Hydrochloride-Additive Systems

Phase separation study of an antidepressant drug, imipramine hydrochloride (IMP), in presence of various additives (i.e., alcohols, sugars, amino acids) has been made by cloud point (CP) measurements. Whereas the CP remained constant with lower alcohols, higher ones (due to their hydrophobic nature) decreased it and medium chain alcohols showed peaked behavior. With diols, the CP remained constant but showed peaked behavior with cycloalkanols. Sugars have a CP decreasing effect because of their water structure making property. All the amino acids increased the CP but to different extent. At different fixed [hexanol], the CP decreased with increasing pH while increase in drug concentration increased the CP. The results are discussed in terms of additive effects on bulk solvent (water) and drug morphology. In the presence and absence of C6OH, the thermodynamic parameters ( , and ) of IMP at CP are found to be positive up to a certain C6OH concentration (90 mM), and above this concentration, the values become negative.

[1]  Kabir-ud-din,et al.  Investigation of the role of electrolytes and non-electrolytes on the cloud point and dye solubilization in antidepressant drug imipramine hydrochloride solutions. , 2008, Colloids and surfaces. B, Biointerfaces.

[2]  V. Aswal,et al.  Clouding phenomenon and SANS studies on tetra-n-butylammonium dodecylsulfate micellar solutions in the absence and presence of salts. , 2006, Journal of colloid and interface science.

[3]  Sanjeev Kumar,et al.  Study of the cloud point of an amphiphilic antidepressant drug: Influence of surfactants, polymers, and non-electrolytes , 2006 .

[4]  D. Shah,et al.  Effect of surfactants on the cloud point of amphiphilic drug solutions , 2003 .

[5]  D. Shah,et al.  A Cloud Point Study on the Micellar Growth of an Amphiphilic Drug in the Presence of Alcohol and Ionic Surfactant , 2003 .

[6]  Sanjeev Kumar,et al.  Salt-induced cloud point in anionic surfactant solutions: Role of the headgroup and additives , 2002 .

[7]  Sanjeev Kumar,et al.  Occurrence of Cloud Points in Sodium Dodecyl Sulfate−Tetra-n-butylammonium Bromide System , 2001 .

[8]  E. Junquera,et al.  Behavior of Tricyclic Antidepressants in Aqueous Solution: Self-Aggregation and Association with β-Cyclodextrin , 2001 .

[9]  S. Schreier,et al.  Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects. , 2000, Biochimica et biophysica acta.

[10]  D. Langevin.  Surfactant Systems , 1999 .

[11]  E. Caponetti,et al.  Localization of n-Alcohols and Structural Effects in Aqueous Solutions of Sodium Dodecyl Sulfate , 1997 .

[12]  Sanjeev Kumar,et al.  Viscosities of Cetylpyridinium Bromide Solutions (Aqueous and Aqueous KBr) in the Presence of Alcohols and Amines , 1997 .

[13]  P. A. Galera-Gómez,et al.  Clouding of Triton X-114: The effect of added electrolytes on the cloud point of Triton X-114 in the presence of ionic surfactants , 1995 .

[14]  K. Mortensen,et al.  The Effect of Medium Chain Length Alcohols on the Micellar Properties of Sodium Dodecyl Sulfate in Sodium Chloride Solutions , 1994 .

[15]  C. Garvey,et al.  Effect of head-group size on micellization and phase behavior in quaternary ammonium surfactant systems , 1993 .

[16]  Guo-Xi Zhao,et al.  The physicochemical properties of aqueous mixtures of cationic-anionic surfactants: II. Micelle growth pattern of equimolar mixtures , 1989 .

[17]  L. Marszall.  The effect of electrolytes on the cloud point of ionic-nonionic surfactant solutions , 1987 .

[18]  G. Karlstroem.  A new model for upper and lower critical solution temperatures in poly(ethylene oxide) solutions , 1985 .

[19]  H. Pitkow,et al.  Basic and Clinical Pharmacology , 1983 .

[20]  R. Zana,et al.  Effect of alcohol on the properties of micellar systems , 1981 .

[21]  B. Ninham,et al.  Micelles, vesicles and microemulsions , 1981 .

[22]  Kohji Hayase,et al.  The Distribution of Higher Alcohols in Aqueous Micellar Solutions , 1977 .

[23]  P. Nandi,et al.  Effects of sugar solutions on the activity coefficients of aromatic amino acids and their N-acetyl ethyl esters , 1976 .

[24]  Gordon M. Lees,et al.  Textbook of Pharmacology , 1970 .