Effects of hepatic impairment on the pharmacokinetics of nilotinib: an open-label, single-dose, parallel-group study.
暂无分享,去创建一个
W. Zhou | N. Gallagher | H. Schran | C. Tanaka | O. Yin | V. Sethuraman | Tsu-han Lin | D. Heuman | D. Fisher
[1] C. Ustun,et al. Nilotinib: a second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia. , 2008, Clinical therapeutics.
[2] Richard Pazdur,et al. Tasigna for Chronic and Accelerated Phase Philadelphia Chromosome–Positive Chronic Myelogenous Leukemia Resistant to or Intolerant of Imatinib , 2008, Clinical Cancer Research.
[3] K. Bhalla,et al. Clinical pharmacokinetics (PK) of AMN107, a novel inhibitor of Bcr-Abl, in healthy subjects and patients with imatinib resistant or intolerant chronic myelogenous leukemia (CML) or relapsed/refractory Ph+ acute lymphocytic leukemia (Ph+ALL). , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[4] K. Bhalla,et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. , 2006, The New England journal of medicine.
[5] J. Mestan,et al. AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL , 2006, British Journal of Cancer.
[6] V. Fischer,et al. Safety, Pharmacokinetics (PK), Metabolism, and Mass Balance of [14C]-AMN107, a Novel Aminopyrimidine Inhibitor of Bcr-Abl Tyrosine Kinase, in Healthy Subjects. , 2005 .
[7] Z. Estrov,et al. AMN107, a novel aminopyrimidine inhibitor of p190 Bcr‐Abl activation and of in vitro proliferation of Philadelphia‐positive acute lymphoblastic leukemia cells , 2005, Cancer.
[8] J. Mestan,et al. AMN107, a Novel Aminopyrimidine Inhibitor of Bcr-Abl, Has In vitro Activity against Imatinib-Resistant Chronic Myeloid Leukemia , 2005, Clinical Cancer Research.
[9] Donna Neuberg,et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. , 2005, Cancer cell.
[10] Vera Mihajlovic‐Madzarevic,et al. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. , 2003, JAMA.
[11] L. Benet,et al. Changes in plasma protein binding have little clinical relevance , 2002, Clinical pharmacology and therapeutics.
[12] V. Rodighiero. Effects of Liver Disease on Pharmacokinetics , 1999, Clinical pharmacokinetics.
[13] D. Morgan,et al. Clinical Pharmacokinetic and Pharmacodynamic Considerations in Patients with Liver Disease , 1995, Clinical pharmacokinetics.
[14] B. Bégaud,et al. Pharmacokinetics and protein binding of cefpiramide in patients with alcoholic cirrhosis , 1991, Clinical pharmacology and therapeutics.
[15] D. Harron. Clinical pharmacokinetics: Concepts and applications (2nd edn.) , 1989 .
[16] R. Pugh,et al. Transection of the oesophagus for bleeding oesophageal varices , 1973, The British journal of surgery.
[17] Cancer Therapy Evaluation Program. Common Terminology Criteria for Adverse Events v3.0 (CTCAE) , 2003 .
[18] P. Palatini,et al. Effect of moderate or severe liver dysfunction on the pharmacokinetics of γ-hydroxybutyric acid , 1996, European Journal of Clinical Pharmacology.
[19] Malcolm Rowland,et al. Clinical pharmacokinetics : concepts and applications , 1989 .
[20] C. G. Child,et al. The liver and portal hypertension , 1964 .
[21] C. G. Child,et al. Surgery and portal hypertension. , 1964, Major problems in clinical surgery.