A difference between B10.D2-n and B10.D2-o strains of mice in rates of irradiation-induced leukemogenesis.

Summary Mice of the congenic strains B10.D2/n and B10.D2/o develop lymphoid leukemia after exposure to X-irradiation. In three of four trials, leukemogenesis rates were significantly higher in B10.D2/n females than in B10.D2/o females. B10.D2/o mice lack complement component C5; B10.D2/n are normal for complement. Spleens of young females of both strains were negative for type C RNA virus gs-antigen. In contrast, most spleens of leukemic mice were gs-antigen positive. All virus isolates were B-trop; i.e., they grew on BALB/c embryo fibroblast cultures but not on SWR embryo cells.

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