l-carnitine modulates free mitochondrial DNA DAMPs and platelet storage lesions during storage of platelet concentrates

[1]  F. Amiri,et al.  Treatment of platelet concentrates with the L-carnitine modulates platelets oxidative stress and platelet apoptosis due to mitochondrial reactive oxygen species reduction and reducing cytochrome C release during storage , 2020, Journal of Thrombosis and Thrombolysis.

[2]  M. Deyhim,et al.  Protective effect of L-carnitine on platelet apoptosis during storage of platelet concentrate. , 2020, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.

[3]  T. Mazard,et al.  Blood contains circulating cell‐free respiratory competent mitochondria , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  Kanika Jain,et al.  Role of Platelet Mitochondria: Life in a Nucleus-Free Zone , 2019, Front. Cardiovasc. Med..

[5]  M. Deyhim,et al.  Effect of L-carnitine on platelet bacterial contamination and platelet metabolism during 5 days of storage of platelet concentrates , 2018 .

[6]  P. Provost,et al.  Pathogen reduction technologies: The pros and cons for platelet transfusion , 2018, Platelets.

[7]  É. Boilard,et al.  Mitochondrial damage‐associated molecular patterns in blood transfusion products , 2017 .

[8]  É. Boilard,et al.  Microparticle and mitochondrial release during extended storage of different types of platelet concentrates , 2017, Platelets.

[9]  F. Hirayama,et al.  Mitochondrial damage‐associated molecular patterns as potential proinflammatory mediators in post–platelet transfusion adverse effects , 2016, Transfusion.

[10]  R. Vani,et al.  Influence of Oxidative Stress on Stored Platelets , 2016, Advances in hematology.

[11]  M. Sebban,et al.  Platelet components associated with adverse reactions: predictive value of mitochondrial DNA relative to biological response modifiers , 2016, Transfusion.

[12]  M. Taghikhani,et al.  L-carnitine effectively improves the metabolism and quality of platelet concentrates during storage , 2015, Annals of Hematology.

[13]  M. Gelb,et al.  Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. , 2014, Blood.

[14]  R. Gonzalez,et al.  Blood transfusion products contain mitochondrial DNA damage-associated molecular patterns: a potential effector of transfusion-related acute lung injury. , 2014, The Journal of surgical research.

[15]  T. Münzel,et al.  Mitochondrial redox signaling: Interaction of mitochondrial reactive oxygen species with other sources of oxidative stress. , 2014, Antioxidants & redox signaling.

[16]  S. Slichter,et al.  Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS). , 2014, Blood.

[17]  John Welsh,et al.  Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function. , 2013, The Journal of surgical research.

[18]  B. Badlou,et al.  Six hours of resting platelet concentrates stored at 22-24 ºC for 48 hours in permeable bags preserved pH, swirling and lactate dehydrogenase better and caused less platelet activation. , 2013, Blood transfusion = Trasfusione del sangue.

[19]  P. Sandgren,et al.  High‐yield Platelet units revealed immediate pH decline and delayed mitochondrial dysfunction during storage in 100% plasma as compared with storage in SSP+ , 2012, Vox sanguinis.

[20]  S. Hopewell,et al.  Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation. , 2012, The Cochrane database of systematic reviews.

[21]  P. Pinton,et al.  Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging , 2011, Journal of signal transduction.

[22]  J. Keaney,et al.  Reactive oxygen species in cardiovascular disease. , 2011, Free radical biology & medicine.

[23]  J. Demarquoy.  l‐carnitine: Structure and Function , 2011 .

[24]  D. Devine,et al.  The platelet storage lesion. , 2010, Clinics in laboratory medicine.

[25]  Jun-sheng Ye,et al.  l-carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway , 2010, Regulatory Peptides.

[26]  B. Wachowicz,et al.  l-carnitine modulates blood platelet oxidative stress , 2010, Cell Biology and Toxicology.

[27]  Timothy D Cummins,et al.  Proteomic and functional characterisation of platelet microparticle size classes , 2009, Thrombosis and Haemostasis.

[28]  S. Orrenius.  Reactive Oxygen Species in Mitochondria-Mediated Cell Death , 2007, Drug metabolism reviews.

[29]  C. Hoppel,et al.  Carnitine: a nutritional, biosynthetic, and functional perspective. , 2004, Molecular aspects of medicine.

[30]  A. Arduini,et al.  l‐carnitine decreases glycolysis in liquid‐stored platelets , 2000, Transfusion.

[31]  V. Skulachev.  Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms. , 1999, Molecular aspects of medicine.

[32]  J. Loscalzo,et al.  Nitric oxide released from activated platelets inhibits platelet recruitment. , 1997, The Journal of clinical investigation.

[33]  Peter F Surai.  Antioxidant Action of Carnitine: Molecular Mechanisms and Practical Applications , 2015 .

[34]  A. Garjani,et al.  EFFECTS OF L-CARNITINE ON CARDIAC APOPTOSIS IN ISCHEMIC- REPERFUSED ISOLATED RAT HEART , 2007 .

[35]  Iaira Boissevain,et al.  Implications of Research for Treatment: Ghb Latest Research Findings Adverse Effects , 2022 .

[36]  P. Gazzaniga,et al.  Carnitine inhibits arachidonic acid turnover, platelet function, and oxidative stress. , 2003, American journal of physiology. Heart and circulatory physiology.