Effect of a low protein diet on the resistance of Churra sheep to Teladorsagia circumcincta

The aim of this study was to understand the influence of a low protein diet on the resistance of the Churra breed sheep to infection with Teladorsagia circumcincta. A previous experiment in our department demonstrated significant differences between resistant and susceptible sheep infected with T. circumcincta, in eggs per gram of faeces, serum pepsinogen, serum IgA and peripheral eosinophilia (unpublished). The sheep were fed with a balanced protein diet. In the current assay there were significant differences between the resistant and susceptible groups in egg output, serum pepsinogen and worm burden. The optical densities (OD) of the IgA in blood samples, nasal secretions and saliva were tested throughout the study and the differences between groups were not significant. At necropsy adult worm length, the number of eggs in utero in adult females, the number of fourth stage larvae and the OD of gastric mucus IgA did not differ between groups either. Moreover, due to diet there was a loss of weight in both groups but this was not significant. Our results support the view that low protein diets could influence immune function and as a result resistant genotypes do not show any superiority in comparison with susceptible ones.

[1]  J. Huntley,et al.  Influence of dietary protein supply on resistance to experimental infections with Haemonchus contortus in Ile de France and Santa Ines lambs. , 2005, Veterinary parasitology.

[2]  S. Walkden-Brown,et al.  Enhancing immunity to nematode parasites in single-bearing Merino ewes through nutrition and genetic selection. , 2003, Veterinary parasitology.

[3]  R. Delfa,et al.  Effect of level of feed intake on the development of gastrointestinal parasitism in growing lambs. , 2002, Veterinary parasitology.

[4]  M. Stear,et al.  The influence of protein supplementation on the immune response to Haemonchus contortus , 2001, Parasite immunology.

[5]  I. Kyriazakis,et al.  Influence of host nutrition on the development and consequences of nematode parasitism in ruminants. , 2001, Trends in parasitology.

[6]  I. Kyriazakis,et al.  Temporal effects of protein nutrition on the growth and immunity of lambs infected with Trichostrongylus colubriformis. , 2000, International journal for parasitology.

[7]  M. Scott,et al.  Energy deficits suppress both systemic and gut immunity during infection. , 1999, Biochemical and biophysical research communications.

[8]  Strain,et al.  The recognition of molecules from fourth‐stage larvae of Ostertagia circumcincta by IgA from infected sheep , 1999, Parasite immunology.

[9]  J. Nolan,et al.  Protein supplementation improves the performance of parasitised sheep fed a straw-based diet. , 1998, International journal for parasitology.

[10]  A. Rasedee,et al.  Dietary protein influences on regulation of Haemonchus Contortus populations in Dorsimal lambs , 1998, Journal of Helminthology.

[11]  G. Gray.  The use of genetically resistant sheep to control nematode parasitism. , 1997, Veterinary parasitology.

[12]  M. Fox,et al.  Pathophysiology of infection with gastrointestinal nematodes in domestic ruminants: recent developments. , 1997, Veterinary parasitology.

[13]  G. Gettinby,et al.  How hosts control worms , 1997, Nature.

[14]  A. Sykes,et al.  Implications of nutrition for the ability of ruminants to withstand gastrointestinal nematode infections. , 1996, International journal for parasitology.

[15]  Q. Mckellar,et al.  Regulation of egg production, worm burden, worm length and worm fecundity by host responses in sheep infected with Ostertagia circumcincta , 1995, Parasite immunology.

[16]  Q. Mckellar,et al.  Local and plasma antibody responses to the parasitic larval stages of the abomasal nematode Ostertagia circumcincta. , 1995, Veterinary parasitology.

[17]  W. Smith,et al.  Effect of dietary protein supplementation on the development of immunity to Ostertagia circumcincta in growing lambs. , 1995, Research in veterinary science.

[18]  A. Sykes.  Parasitism and production in farm animals , 1994 .

[19]  P. Holmes,et al.  Influence of dietary protein on the pathophysiology of haemonchosis in lambs given continuous infections. , 1988, Research in veterinary science.

[20]  P. Holmes,et al.  The effect of dietary protein on the pathophysiology of acute ovine haemonchosis. , 1986, Veterinary parasitology.

[21]  R. Jepson,et al.  Value of Plasma Pepsinogen Estimation , 1960, British medical journal.

[22]  Farm Buildings,et al.  Ministry of Agriculture, Fisheries and Food- , 1956 .

[23]  P. Holmes,et al.  Influence of dietary protein on the pathophysiology of ovine haemonchosis in Finn Dorset and Scottish Blackface lambs given a single moderate infection. , 1985, Research in veterinary science.

[24]  W. Jarrett,et al.  Experimental Ostertagia circumcincta infections in sheep: development and pathogenesis of a single infection. , 1966 .