Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
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T. Graczyk | Michael Koblish | R. Dolle | L. Leister | B. Brogdon | J. Cassel | B. Le Bourdonnec | D. Christ | R. Dehaven | R. Windh | D. DeHaven-Hudkins | Christopher W. Ajello | S. Belanger | M. Feschenko | Minghua Gu | G. Chu | P. Tuthill | M. Derelanko | Patrick J. Little | W. Barker | Steven A Smith | Daniel D Wiant | S. Kutz | P. J. Little