Risk factors for anastomotic leakage and leak‐related mortality after colonic cancer surgery in a nationwide audit

Surgical resection with restoration of bowel continuity is the cornerstone of treatment for patients with colonic cancer. The aim of this study was to identify risk factors for anastomotic leakage (AL) and subsequent death after colonic cancer surgery.

[1]  V. Lemmens,et al.  The Dutch surgical colorectal audit. , 2013, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[2]  T. Wiggers,et al.  An increasing use of defunctioning stomas after low anterior resection for rectal cancer. Is this the way to go? , 2013, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[3]  K. Havenga,et al.  Anastomotic leakage as an outcome measure for quality of colorectal cancer surgery , 2013, BMJ quality & safety.

[4]  R. Tollenaar,et al.  Nonelective Colon Cancer Resections in Elderly Patients: Results from the Dutch Surgical Colorectal Audit , 2012, Digestive Surgery.

[5]  B. Bonsing,et al.  Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality. , 2012, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[6]  P. Krarup,et al.  A nationwide study on anastomotic leakage after colonic cancer surgery , 2012, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[7]  S. Leichtle,et al.  Risk Factors for Anastomotic Leakage After Colectomy , 2012, Diseases of the colon and rectum.

[8]  P. Wille-Jørgensen,et al.  Workload and surgeon's specialty for outcome after colorectal cancer surgery. , 2012, The Cochrane database of systematic reviews.

[9]  G. Patijn,et al.  Reoperation After Colorectal Surgery Is an Independent Predictor of the 1-Year Mortality Rate , 2011, Diseases of the colon and rectum.

[10]  M. Kuskowski,et al.  Variation of mortality after coronary artery bypass surgery in relation to hour, day and month of the procedure , 2011, BMC cardiovascular disorders.

[11]  M. Zielinski,et al.  Emergency Management of Perforated Colon Cancers: How Aggressive Should We Be? , 2011, Journal of Gastrointestinal Surgery.

[12]  H. Lippert,et al.  Low‐volume centre vs high‐volume: the role of a quality assurance programme in colon cancer surgery , 2011, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[13]  Lars C Richardson,et al.  Does late night hip surgery affect outcome? , 2011, The Journal of trauma.

[14]  N. Melamed,et al.  The effect of time of day on outcome of unscheduled cesarean deliveries , 2011, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[15]  Hein Putter,et al.  Predicting the risk of anastomotic leakage in left-sided colorectal surgery using a colon leakage score. , 2011, The Journal of surgical research.

[16]  P. Krijnen,et al.  Disparities in quality of care for colon cancer between hospitals in the Netherlands. , 2010, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[17]  F. Benedix,et al.  Anastomotic leakage after colon cancer surgery: a predictor of significant morbidity and hospital mortality, and diminished tumour-free survival. , 2010, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[18]  A. Nesbakken,et al.  Short term outcome after emergency and elective surgery for colon cancer , 2009, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[19]  H. Putter,et al.  Multicentre analysis of oncological and survival outcomes following anastomotic leakage after rectal cancer surgery , 2009, The British journal of surgery.

[20]  C. V. D. van de Velde,et al.  Improved diagnosis and treatment of anastomotic leakage after colorectal surgery. , 2009, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[21]  N. Harlaar,et al.  Surgeons lack predictive accuracy for anastomotic leakage in gastrointestinal surgery , 2009, International Journal of Colorectal Disease.

[22]  B. George,et al.  The management and outcome of anastomotic leaks in colorectal surgery , 2008, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[23]  M. Secic,et al.  Incidence, consequences, and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study , 2008, International Journal of Colorectal Disease.

[24]  S. Msika,et al.  Anastomotic leakage after elective right versus left colectomy for cancer: prevalence and independent risk factors. , 2007, Journal of the American College of Surgeons.

[25]  P. Morel,et al.  Lessons learned from one thousand consecutive colonic resections in a teaching hospital. , 2007, Swiss medical weekly.

[26]  J. Ho,et al.  Anastomotic Leakage is Associated with Poor Long-Term Outcome in Patients After Curative Colorectal Resection for Malignancy , 2007, Journal of Gastrointestinal Surgery.

[27]  W. Law,et al.  Leakage After Resection and Intraperitoneal Anastomosis for Colorectal Malignancy: Analysis of Risk Factors , 2006, Diseases of the colon and rectum.

[28]  B. Parry,et al.  ANASTOMOTIC LEAKAGE AFTER LOWER GASTROINTESTINAL ANASTOMOSIS: MEN ARE AT A HIGHER RISK , 2006, ANZ journal of surgery.

[29]  P. Renzulli,et al.  The influence of the surgeon's and the hospital's caseload on survival and local recurrence after colorectal cancer surgery. , 2006, Surgery.

[30]  E. Jaurrieta,et al.  Anastomotic Dehiscence After Resection and Primary Anastomosis in Left-Sided Colonic Emergencies , 2005, Diseases of the colon and rectum.

[31]  C. Marijnen,et al.  Risk factors for anastomotic failure after total mesorectal excision of rectal cancer , 2005, The British journal of surgery.

[32]  C. Begg,et al.  Surgeon volume compared to hospital volume as a predictor of outcome following primary colon cancer resection , 2003, Journal of surgical oncology.

[33]  W. Hohenberger,et al.  Surgery for Colon Cancer , 2003, Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society.

[34]  M. Pocard,et al.  Factors Associated with Clinically Significant Anastomotic Leakage after Large Bowel Resection: Multivariate Analysis of 707 Patients , 2002, World Journal of Surgery.

[35]  R. Poon,et al.  Emergency surgery for obstructing colorectal cancers: a comparison between right-sided and left-sided lesions. , 2001, Journal of the American College of Surgeons.

[36]  C. Begg,et al.  Influence of hospital procedure volume on outcomes following surgery for colon cancer. , 2000, JAMA.

[37]  J. Gold,et al.  Validation of a combined comorbidity index. , 1994, Journal of clinical epidemiology.

[38]  H. Drummond Some Points Relating to the Surgical Anatomy of the Arterial Supply of the Large Intestine , 1914, Proceedings of the Royal Society of Medicine.

[39]  Masaaki Ito,et al.  Diverting stoma in rectal cancer surgery. A retrospective study of 329 patients from Japanese cancer centers , 2010, International Journal of Colorectal Disease.

[40]  J. Coebergh,et al.  Which Comorbid Conditions Predict Complications after Surgery for Colorectal Cancer? , 2005, World Journal of Surgery.

[41]  James O. Finckenauer Editor’s commentary , 2005 .

[42]  J. Meyerhardt,et al.  Impact of hospital procedure volume on surgical operation and long-term outcomes in high-risk curatively resected rectal cancer: findings from the Intergroup 0114 Study. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[43]  H. L. Young,et al.  High tie of the inferior mesenteric artery in distal colorectal resections —a safe vascular procedure , 2004, International Journal of Colorectal Disease.

[44]  M. Freitag,et al.  Anastomotic leakage: impact on local recurrence and survival in surgery of colorectal cancer , 1998, International Journal of Colorectal Disease.

[45]  C. Mackenzie,et al.  A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. , 1987, Journal of chronic diseases.