Preliminary investigations of magnetic modulated nanoparticles for microwave breast cancer detection

Abstract This paper investigates the potential of magnetic modulated iron oxide nanoparticles in terms of a contrast enhancement for Ultra-wideband (UWB) breast imaging. The work is motivated by the low dielectric contrast between tumor and normal glandular/fibroconnective tissue. The influence of an external polarizing magnetic field on pure and coated magnetite nanoparticles is investigated in this contribution. Measurements were conducted using M-sequence UWB technology and an oil-gelatin phantom. It is shown that a coating, which is necessary for clinical use, results in a lower signal response, and thus leads to a lower detectability of magnetic modulated nanoparticles.

[1]  M. Lindstrom,et al.  A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries , 2007, Physics in medicine and biology.

[2]  Marko Helbig,et al.  Design and Test of an Imaging System for UWB Breast Cancer Detection , 2012 .

[3]  Paul M. Meaney,et al.  Enhancing breast tumor detection with near-field imaging , 2002 .

[4]  Gennaro Bellizzi,et al.  Microwave Cancer Imaging Exploiting Magnetic Nanoparticles as Contrast Agent , 2011, IEEE Transactions on Biomedical Engineering.

[5]  D. R. Gibbins,et al.  Clinical trials of a UWB imaging radar for breast cancer , 2010, Proceedings of the Fourth European Conference on Antennas and Propagation.

[6]  G. Bellizzi,et al.  A Novel Measurement Technique for the Broadband Characterization of Diluted Water Ferrofluids for Biomedical Applications , 2013, IEEE Transactions on Magnetics.

[7]  E. Madsen,et al.  Tissue-mimicking phantom materials for narrowband and ultrawideband microwave applications , 2005, Physics in medicine and biology.

[8]  Jeremie Bourqui,et al.  A Prototype System for Measuring Microwave Frequency Reflections from the Breast , 2012, Int. J. Biomed. Imaging.

[9]  Kayvan Najarian,et al.  Fracture Detection in Traumatic Pelvic CT Images , 2012, Int. J. Biomed. Imaging.

[10]  Jürgen Sachs,et al.  Handbook of Ultra-Wideband Short-Range Sensing: Theory, Sensors, Applications , 2012 .

[11]  R. Hong,et al.  Preparation and characterization of magnetite/dextran nanocomposite used as a precursor of magnetic fluid , 2009 .

[12]  R. C. Conceicao,et al.  Initial classification of breast tumour phantoms using a UWB radar prototype , 2013, 2013 International Conference on Electromagnetics in Advanced Applications (ICEAA).

[13]  J. Sachs,et al.  Experimental feasibility study of contrast agent enhanced UWB breast imaging by means of M-sequence sensor systems , 2014, The 8th European Conference on Antennas and Propagation (EuCAP 2014).

[14]  R. Benjamin,et al.  Towards contrast enhanced breast imaging using ultra-wideband microwave radar system , 2010, 2010 IEEE Radio and Wireless Symposium (RWS).