Information and organization in public health institutes: an ontology-based modeling of the entities in the reception-analysis-report phases

BackgroundOntologies are widely used both in the life sciences and in the management of public and private companies. Typically, the different offices in an organization develop their own models and related ontologies to capture specific tasks and goals. Although there might be an overall coordination, the use of distinct ontologies can jeopardize the integration of data across the organization since data sharing and reusability are sensitive to modeling choices.ResultsThe paper provides a study of the entities that are typically found at the reception, analysis and report phases in public institutes in the life science domain. Ontological considerations and techniques are introduced and their implementation exemplified by studying the Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), a public veterinarian institute with different geographical locations and several laboratories. Different modeling issues are discussed like the identification and characterization of the main entities in these phases; the classification of the (types of) data; the clarification of the contexts and the roles of the involved entities. The study is based on a foundational ontology and shows how it can be extended to a comprehensive and coherent framework comprising the different institute’s roles, processes and data. In particular, it shows how to use notions lying at the borderline between ontology and applications, like that of knowledge object. The paper aims to help the modeler to understand the core viewpoint of the organization and to improve data transparency.ConclusionsThe study shows that the entities at play can be analyzed within a single ontological perspective allowing us to isolate a single ontological framework for the whole organization. This facilitates the development of coherent representations of the entities and related data, and fosters the use of integrated software for data management and reasoning across the company.

[1]  Nicola Guarino,et al.  The Won-derWeb Library of Foundational Ontologies , 2002 .

[2]  Ketil Stølen,et al.  What is model driven architecture , 2003 .

[3]  Stefano Borgo,et al.  Knowledge objects: a formal construct for material, information and role dependences , 2012 .

[4]  Grant W. Montgomery,et al.  Impact of the Genome on the Epigenome Is Manifested in DNA Methylation Patterns of Imprinted Regions in Monozygotic and Dizygotic Twins , 2011, PloS one.

[5]  Michel Dumontier,et al.  Towards quantitative measures in applied ontology , 2012, ArXiv.

[6]  Axel Uhl,et al.  Model-Driven Architecture , 2002, OOIS Workshops.

[7]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[8]  Frank Loebe,et al.  Abstract vs. social roles - Towards a general theoretical account of roles , 2007, Appl. Ontology.

[9]  Greg Law,et al.  The Prevalence of Sexually Transmitted Infections in Papua New Guinea: A Systematic Review and Meta-Analysis , 2010, PloS one.

[10]  Riichiro Mizoguchi,et al.  The model of roles within an ontology development tool: Hozo , 2007, Appl. Ontology.

[11]  Nicola Guarino,et al.  Social Roles and their Descriptions , 2004, KR.

[12]  D Kenny ISO and CEN documents on quality in medical laboratories. , 2001, Clinica chimica acta; international journal of clinical chemistry.

[13]  N. F. Noy,et al.  Ontology Development 101: A Guide to Creating Your First Ontology , 2001 .

[14]  C. McDonald,et al.  LOINC, a universal standard for identifying laboratory observations: a 5-year update. , 2003, Clinical chemistry.

[15]  Michael Gruninger,et al.  Methodology for the Design and Evaluation of Ontologies , 1995, IJCAI 1995.

[16]  R. Ferrario,et al.  Towards a Computational Ontology of Mind , 2005, 2005 IEEE Aerospace Conference.

[17]  Mary K Pulvermacher,et al.  Toward the Use of an Upper Ontology for U.S. Government and U.S. Military Domains: An Evaluation , 2004 .

[18]  Nicola Guarino,et al.  The WonderWeb Library of Foundational Ontologies Preliminary Report , 2002 .

[19]  Riichiro MIZOGUCHI,et al.  Tutorial on ontological engineering Part 2: Ontology development, tools and languages , 2004, New Generation Computing.

[20]  Stefano Borgo,et al.  Foundational Choices in DOLCE , 2009, Handbook on Ontologies.

[21]  Alan L. Rector,et al.  Binding Ontologies & Coding Systems to Electronic Health Records and Messages , 2006, KR-MED.

[22]  Nicolette de Keizer,et al.  Forty years of SNOMED: a literature review , 2008, BMC Medical Informatics Decis. Mak..

[23]  Giovanni Sartor,et al.  Classifications and the Law: Doctrinal Classifications vs. Computational Ontologies , 2010 .

[24]  Stefano Borgo,et al.  Artefacts and Roles: Modelling Strategies in a Multiplicative Ontology , 2008, FOIS.

[25]  O Bodenreider,et al.  Biomedical ontologies in action: role in knowledge management, data integration and decision support. , 2008, Yearbook of medical informatics.

[26]  José L. V. Mejino,et al.  A reference ontology for biomedical informatics: the Foundational Model of Anatomy , 2003, J. Biomed. Informatics.

[27]  Stefano Borgo,et al.  Disentangling Knowledge Objects , 2009, FOMI.

[28]  Robert Arp,et al.  Function, Role and Disposition in Basic Formal Ontology , 2008 .

[29]  Helena F. Deus,et al.  A Semantic Web Management Model for Integrative Biomedical Informatics , 2008, PloS one.

[30]  Thomas R. Gruber,et al.  Toward principles for the design of ontologies used for knowledge sharing? , 1995, Int. J. Hum. Comput. Stud..

[31]  Carola Eschenbach,et al.  Formal Ontology in Information Systems , 2008 .

[32]  Nicola Guarino,et al.  An Overview of OntoClean , 2004, Handbook on Ontologies.

[33]  Asunción Gómez-Pérez,et al.  Evaluation of ontologies , 2001, International Journal of Intelligent Systems.

[34]  Paula M. Mabee,et al.  Phenex: Ontological Annotation of Phenotypic Diversity , 2010, PloS one.

[35]  Gilles Kassel,et al.  A formal ontology of artefacts , 2010, Appl. Ontology.

[36]  Stefano Borgo,et al.  Technical artifacts: An integrated perspective , 2014, Appl. Ontology.

[37]  A. Rector,et al.  Relations in biomedical ontologies , 2005, Genome Biology.

[38]  Mary E. Mangan,et al.  The Adult Mouse Anatomical Dictionary: a tool for annotating and integrating data , 2005, Genome Biology.

[39]  Stefano Borgo,et al.  Proceedings of the Joint Ontology Workshops 2016 at 9th International Conference on Formal Ontology in Information Systems , 2016 .

[40]  Jan Mendling,et al.  Business Process Model and Notation , 2012, Lecture Notes in Business Information Processing.

[41]  C. Maria Keet,et al.  A Formal Theory of Granularity , 2008 .

[42]  Michel Dumontier,et al.  Interoperability between Biomedical Ontologies through Relation Expansion, Upper-Level Ontologies and Automatic Reasoning , 2011, PloS one.

[43]  A. Rector Thesauri and Formal Classifications: Terminologies for People and Machines , 1998, Methods of Information in Medicine.

[44]  Guido Boella,et al.  Roles, an interdisciplinary perspective , 2007, Appl. Ontology.

[45]  C. Maria Keet The Use of Foundational Ontologies in Ontology Development: An Empirical Assessment , 2011, ESWC.

[46]  Till Mossakowski,et al.  A Modular Consistency Proof for DOLCE , 2011, AAAI.

[47]  Holger Knublauch,et al.  The Protégé OWL Plugin: An Open Development Environment for Semantic Web Applications , 2004, SEMWEB.