T cell activation induces CuZn superoxide dismutase (SOD)-1 intracellular re-localization, production and secretion.

[1]  S. Mehrotra,et al.  Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease. , 2013, Antioxidants & redox signaling.

[2]  J. Licht,et al.  Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. , 2013, Immunity.

[3]  P. Krammer,et al.  Manganese superoxide dismutase: a regulator of T cell activation-induced oxidative signaling and cell death. , 2012, Biochimica et biophysica acta.

[4]  Anne‐Frances Miller Superoxide dismutases: Ancient enzymes and new insights , 2012, FEBS letters.

[5]  M. Remberger,et al.  N‐acetyl‐L‐cysteine increases acute graft‐versus‐host disease and promotes T‐cell‐mediated immunity in vitro , 2011, European journal of immunology.

[6]  J. Heo Redox control of GTPases: from molecular mechanisms to functional significance in health and disease. , 2011, Antioxidants & redox signaling.

[7]  R. Holmdahl,et al.  Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species , 2010, Proceedings of the National Academy of Sciences.

[8]  S. Mathivanan,et al.  Exosomes: extracellular organelles important in intercellular communication. , 2010, Journal of proteomics.

[9]  F. Miot,et al.  The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling , 2010, Science Signaling.

[10]  E. Clark,et al.  BCR‐induced superoxide negatively regulates B‐cell proliferation and T‐cell‐independent type 2 Ab responses , 2009, European journal of immunology.

[11]  J. Engelhardt,et al.  Lipid Rafts and Caveolin-1 Coordinate Interleukin-1β (IL-1β)-dependent Activation of NFκB by Controlling Endocytosis of Nox2 and IL-1β Receptor 1 from the Plasma Membrane* , 2009, The Journal of Biological Chemistry.

[12]  C. Théry,et al.  Membrane vesicles as conveyors of immune responses , 2009, Nature Reviews Immunology.

[13]  A. Sarin,et al.  Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis , 2009, The Journal of experimental medicine.

[14]  J. Engelhardt,et al.  Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha. , 2009, Antioxidants & redox signaling.

[15]  G. Koretzky,et al.  T cell activation. , 2009, Annual review of immunology.

[16]  R. Germain,et al.  Navigating the network: signaling cross-talk in hematopoietic cells , 2009, Nature Immunology.

[17]  A. Secondo,et al.  The Cu-Zn superoxide dismutase (SOD1) inhibits ERK phosphorylation by muscarinic receptor modulation in rat pituitary GH3 cells. , 2008, Biochemical and biophysical research communications.

[18]  I. Tooyama,et al.  The endoplasmic reticulum‐Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  D. Shaw,et al.  Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling , 2008, Proceedings of the National Academy of Sciences.

[20]  H. Paulson,et al.  SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. , 2008, The Journal of clinical investigation.

[21]  F. Benfenati,et al.  Evidence of calcium‐ and SNARE‐dependent release of CuZn superoxide dismutase from rat pituitary GH3 cells and synaptosomes in response to depolarization , 2007, Journal of neurochemistry.

[22]  M. Gold,et al.  Differential role of reactive oxygen species in the activation of mitogen-activated protein kinases and Akt by key receptors on B-lymphocytes: CD40, the B cell antigen receptor, and CXCR4 , 2007, Journal of Cell Communication and Signaling.

[23]  M. Ushio-Fukai Localizing NADPH Oxidase–Derived ROS , 2006, Science's STKE.

[24]  R. Maier,et al.  The diverse antioxidant systems of Helicobacter pylori , 2006, Molecular microbiology.

[25]  S. Rhee,et al.  H2O2, a Necessary Evil for Cell Signaling , 2006, Science.

[26]  G. McKhann,et al.  Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[27]  Aled Clayton,et al.  Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids , 2006, Current protocols in cell biology.

[28]  D. Golde,et al.  Hydrogen peroxide generated extracellularly by receptor-ligand interaction facilitates cell signaling. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[29]  A. Hill,et al.  Impaired Extracellular Secretion of Mutant Superoxide Dismutase 1 Associates with Neurotoxicity in Familial Amyotrophic Lateral Sclerosis , 2005, The Journal of Neuroscience.

[30]  P. Formisano,et al.  Cu,Zn superoxide dismutase increases intracellular calcium levels via a phospholipase C-protein kinase C pathway in SK-N-BE neuroblastoma cells. , 2004, Biochemical and biophysical research communications.

[31]  F. Fang Antimicrobial reactive oxygen and nitrogen species: concepts and controversies , 2004, Nature Reviews Microbiology.

[32]  J. Kwon,et al.  T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation , 2004, Nature Immunology.

[33]  J. Lambeth NOX enzymes and the biology of reactive oxygen , 2004, Nature Reviews Immunology.

[34]  J. Kwon,et al.  T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation. , 2003, Free radical biology & medicine.

[35]  D. Bar-Sagi,et al.  Redox-dependent downregulation of Rho by Rac , 2003, Nature Cell Biology.

[36]  D. Greco,et al.  The Cu,Zn superoxide dismutase in neuroblastoma SK-N-BE cells is exported by a microvesicles dependent pathway. , 2003, Brain research. Molecular brain research.

[37]  Michael Reth,et al.  Hydrogen peroxide as second messenger in lymphocyte activation , 2002, Nature Immunology.

[38]  P. Mondola,et al.  CuZn-superoxide dismutase in human thymus: immunocytochemical localisation and secretion in thymus-derived epithelial and fibroblast cell lines , 2002, Histochemistry and Cell Biology.

[39]  A. Régnault,et al.  TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex1 , 2002, The Journal of Immunology.

[40]  L. Oberley,et al.  Discrete Generation of Superoxide and Hydrogen Peroxide by T Cell Receptor Stimulation , 2002, The Journal of experimental medicine.

[41]  L. Zhu,et al.  Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade* , 2001, The Journal of Biological Chemistry.

[42]  K. Schulze-Osthoff,et al.  Enhancement of T Cell Receptor Signaling by a Mild Oxidative Shift in the Intracellular Thiol Pool1 , 2000, The Journal of Immunology.

[43]  Sue Goo Rhee,et al.  Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation Through Cysteine Oxidation , 2000, Science's STKE.

[44]  R M Day,et al.  Ras‐dependent and ‐independent regulation of reactive oxygen species by mitogenic growth factors and TGF‐β1 , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[45]  S. Marklund,et al.  Multiple cytokines regulate the expression of extracellular superoxide dismutase in human vascular smooth muscle cells. , 2000, Atherosclerosis.

[46]  S. Rhee,et al.  Platelet-derived Growth Factor-induced H2O2 Production Requires the Activation of Phosphatidylinositol 3-Kinase* , 2000, The Journal of Biological Chemistry.

[47]  K. Ha,et al.  Hydrogen Peroxide Activates p70S6k Signaling Pathway* , 1999, The Journal of Biological Chemistry.

[48]  J. Skolnick,et al.  Structure‐based functional motif identifies a potential disulfide oxidoreductase active site in the serine/threonine protein phosphatase‐1 subfamily , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  T. Kizaki,et al.  Tissue distribution of immunoreactive mouse extracellular superoxide dismutase. , 1998, American journal of physiology. Cell physiology.

[50]  B. Silvestrini,et al.  Rat testicular extracellular superoxide dismutase: its purification, cellular distribution, and regulation. , 1998, Biology of reproduction.

[51]  R. Alexander,et al.  p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II , 1998, The Journal of Biological Chemistry.

[52]  M. Santillo,et al.  Secretion and Increase of Intracellular CuZn Superoxide Dismutase Content in Human Neuroblastoma SK-N-BE Cells Subjected to Oxidative Stress , 1998, Brain Research Bulletin.

[53]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[54]  Y Nishizuka,et al.  Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[55]  E. Tekle,et al.  Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide , 1997, The Journal of Biological Chemistry.

[56]  R. Burdon Control of cell proliferation by reactive oxygen species. , 1996, Biochemical Society transactions.

[57]  M. S. Williams,et al.  Role of reactive oxygen intermediates in TCR-induced death of T cell blasts and hybridomas. , 1996, Journal of immunology.

[58]  M. Santillo,et al.  Evidence for secretion of cytosolic CuZn superoxide dismutase by Hep G2 cells and human fibroblasts. , 1996, The international journal of biochemistry & cell biology.

[59]  A. Weissman,et al.  T Cell Antigen Receptor Ubiquitination Is a Consequence of Receptor-mediated Tyrosine Kinase Activation (*) , 1996, The Journal of Biological Chemistry.

[60]  V. Ferrans,et al.  Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction , 1995, Science.

[61]  K. Schulze-Osthoff,et al.  IL‐2 gene expression and NF‐kappa B activation through CD28 requires reactive oxygen production by 5‐lipoxygenase. , 1995, The EMBO journal.

[62]  R. Abraham,et al.  Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. , 1993, The Journal of biological chemistry.

[63]  Anne J. Ridley,et al.  The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors , 1992, Cell.

[64]  E. D. Harris,et al.  Regulation of antioxidant enzymes 1 , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[65]  J. Lippincott-Schwartz,et al.  Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae , 1991, Cell.

[66]  M. Gerber,et al.  Oxidative phenomena are implicated in human T-cell stimulation. , 1988, Immunology.

[67]  L. Tibell,et al.  Expression of human extracellular superoxide dismutase in Chinese hamster ovary cells and characterization of the product. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[68]  S. Marklund,et al.  Human copper-containing superoxide dismutase of high molecular weight. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[69]  I. Pastan,et al.  Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface , 1979, Nature.

[70]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[71]  P. Nadeau,et al.  Modulation of CD40-activated B lymphocytes by N-acetylcysteine involves decreased phosphorylation of STAT3. , 2012, Molecular immunology.

[72]  A. Secondo,et al.  Cigarette Smoke Condensate Causes a Decrease of the Gene Expression of Cu–Zn Superoxide Dismutase, Mn Superoxide Dismutase, Glutathione Peroxidase, Catalase, and Free Radical-Induced Cell Injury in SH-SY5Y Human Neuroblastoma Cells , 2009, Neurotoxicity Research.

[73]  K. Krause,et al.  The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. , 2007, Physiological reviews.

[74]  E. Peterhans Reactive oxygen species and nitric oxide in viral diseases , 2007, Biological Trace Element Research.

[75]  A. Sik,et al.  Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis , 2006, Nature Neuroscience.

[76]  B. Chain,et al.  The role of reactive oxygen species in triggering proliferation and IL-2 secretion in T cells. , 1999, Free radical biology & medicine.