Vitamin K Deficiency From Long‐Term Warfarin Anticoagulation Does Not Alter Skeletal Status in Male Rhesus Monkeys

Vitamin K (K) inadequacy may cause bone loss. Thus, K deficiency induced by anticoagulants (e.g., warfarin) may be an osteoporosis risk factor. The skeletal impact of long‐term warfarin anticoagulation was evaluated in male monkeys. No effect on BMD or bone markers of skeletal turnover was observed. This study suggests that warfarin‐induced K deficiency does not have skeletal effects.

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