Laser epithelial keratomileusis in 2010 – a review

Photorefractive keratectomy, laser epithelial keratomileusis (LASEK) and Epi‐LASIK are all variants of a similar type refractive surgery involving laser on the surface of the cornea and differ mainly in management of the epithelium. Although laser in situ keratomileusis (LASIK) is currently the most popular form of refractive surgery, LASEK is the procedure of choice in some patients. We highlight potential complications of LASEK and how these may be managed. Following laser refractive surgery, corneal thickness is reduced, which has implications for intraocular pressure measurement and glaucoma screening and management. This is particularly important following surface laser procedures where no evidence of previous surgery may be visible. In the event that cataract surgery is required at a later date, correct calculation of the appropriate intraocular lens power can be difficult and it thus important that patients are given their preoperative keratometry readings and refraction. Compared with LASIK patients, those who undergo LASEK are considered to be at lower risk of corneal ectasia. Improved understanding of wound healing post LASEK and better postoperative pain management are ongoing challenges.

[1]  Massimo Camellin Laser epithelial keratomileusis with mitomycin C: indications and limits. , 2004, Journal of refractive surgery.

[2]  B. Glasgow,et al.  Corneal scarring after photorefractive keratectomy in a penetrating keratoplasty. , 1996, American journal of ophthalmology-glaucoma.

[3]  M. Lemp,et al.  Advances in understanding and managing dry eye disease. , 2008, American journal of ophthalmology.

[4]  S. Arshinoff,et al.  Corneal subepithelial infiltrates following excimer laser photorefractive keratectomy , 1995, Journal of cataract and refractive surgery.

[5]  A. Shortt,et al.  Evidence for superior efficacy and safety of LASIK over photorefractive keratectomy for correction of myopia. , 2006, Ophthalmology.

[6]  M. O'Keefe,et al.  Randomized clinical trial of topical sodium hyaluronate after excimer laser photorefractive keratectomy. , 1995, Journal of refractive surgery.

[7]  M. O'Keefe,et al.  Laser‐assisted subepithelial keratectomy retreatment after laser in situ keratomileusis , 2008, Journal of cataract and refractive surgery.

[8]  P. Condon,et al.  Twelve-year follow-up of photorefractive keratectomy for low to moderate myopia. , 2006, Journal of refractive surgery.

[9]  L. Le,et al.  Mycobacterium chelonae keratitis after laser-assisted subepithelial keratectomy. , 2006, Journal of cataract and refractive surgery.

[10]  W. Haigis Intraocular lens calculation after refractive surgery for myopia: Haigis‐L formula , 2008, Journal of cataract and refractive surgery.

[11]  L. de Benito-Llopis,et al.  Comparison of visual results between laser-assisted subepithelial keratectomy and epipolis laser in situ keratomileusis to correct myopia and myopic astigmatism. , 2008, American journal of ophthalmology.

[12]  P. Majmudar,et al.  Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery. , 2000, Ophthalmology.

[13]  J. Marshall,et al.  Excimer laser photorefractive keratectomy for hyperopia: 7.5‐year follow‐up , 2005, Journal of cataract and refractive surgery.

[14]  C. Foster,et al.  Serious complications of topical mitomycin-C after pterygium surgery. , 1992, Ophthalmology.

[15]  R. Autrata,et al.  Laser‐assisted subepithelial keratectomy and photorefractive keratectomy for the correction of hyperopia: Results of a 2‐year follow‐up , 2003, Journal of cataract and refractive surgery.

[16]  M. O'Keefe,et al.  A Double-Blind Randomized Control Study to Determine the Effect of Visthesia™ Viscoelastic Substance on Pain following LASEK , 2008, Ophthalmologica.

[17]  K. Miyata,et al.  Comparison of laser in situ keratomileusis and photorefractive keratectomy results: Long‐term follow‐up , 2008, Journal of cataract and refractive surgery.

[18]  S. Masket,et al.  Simple regression formula for intraocular lens power adjustment in eyes requiring cataract surgery after excimer laser photoablation , 2006, Journal of cataract and refractive surgery.

[19]  W. Green,et al.  Modulation of corneal wound healing after excimer laser keratomileusis using topical mitomycin C and steroids. , 1991, Archives of ophthalmology.

[20]  B. Tengroth,et al.  Wound healing and myopic regression following photorefractive keratectomy , 1994, Acta ophthalmologica.

[21]  D. Lam,et al.  Ptosis after laser in situ keratomileusis. , 2004, Journal of cataract and refractive surgery.

[22]  J. Marshall,et al.  Laser epithelial keratomileusis for the correction of hyperopia using a 7.0-mm optical zone with the Schwind ESIRIS laser. , 2007, Journal of refractive surgery.

[23]  J. Curnow,et al.  Cytokine and chemokine levels in tears and in corneal fibroblast cultures before and after excimer laser treatment , 2009, Journal of cataract and refractive surgery.

[24]  E. Spoerl,et al.  A correction formula for the real intraocular pressure after LASIK for the correction of myopic astigmatism. , 2006, Journal of refractive surgery.

[25]  N. Ehlers,et al.  Treatment of post-keratoplasty astigmatism by topography supported customized laser ablation. , 2001, Acta ophthalmologica Scandinavica.

[26]  C. Munnerlyn,et al.  Photorefractive keratectomy: A technique for laser refractive surgery , 1988, Journal of cataract and refractive surgery.

[27]  M. Netto,et al.  Flap lift for LASIK retreatment in eyes with myopia. , 2004, Ophthalmology.

[28]  J. Salz,et al.  Development of unilateral corneal ectasia after PRK with ipsilateral preoperative forme fruste keratoconus. , 2008, Journal of refractive surgery.

[29]  T. O'brien,et al.  Infectious keratitis after photorefractive keratectomy. , 2003, Ophthalmology.

[30]  D. Azar,et al.  Laser subepithelial keratomileusis: electron microscopy and visual outcomes of flap photorefractive keratectomy , 2001, Current opinion in ophthalmology.

[31]  T. Tokoro,et al.  Cooling effect on excimer laser photorefractive keratectomy. , 1999, Journal of cataract and refractive surgery.

[32]  N. Çağıl,et al.  Effectiveness of laser‐assisted subepithelial keratectomy to treat residual refractive errors after laser in situ keratomileusis , 2007, Journal of cataract and refractive surgery.

[33]  R. Brancato,et al.  Evaluation of photorefractive keratectomy retreatments after regressed myopic laser in situ keratomileusis. , 2001, Ophthalmology.

[34]  J. Marshall,et al.  A long-term study of photorefractive keratectomy; 12-year follow-up. , 2004, Ophthalmology.

[35]  Francesco Carones,et al.  Evaluation of the prophylactic use of mitomycin‐C to inhibit haze formation after photorefractive keratectomy , 2002, Journal of cataract and refractive surgery.

[36]  C. Kirwan,et al.  Postoperative pain following epi-LASIK, LASEK, and PRK for myopia. , 2006, Journal of refractive surgery.

[37]  Massimo Camellin Laser epithelial keratomileusis for myopia. , 2003, Journal of refractive surgery.

[38]  J. J. Beerthuizen,et al.  Surface ablation after laser in situ keratomileusis: Retreatment on the flap , 2007, Journal of cataract and refractive surgery.

[39]  R. D. Stulting,et al.  Risk factors and prognosis for corneal ectasia after LASIK. , 2002, Ophthalmology.

[40]  P. Calvas,et al.  Corneal ectasia after photorefractive keratectomy for low myopia. , 2006, Ophthalmology.

[41]  G. Seong,et al.  Comparison of laser epithelial keratomileusis and photorefractive keratectomy for low to moderate myopia , 2001, Journal of cataract and refractive surgery.

[42]  H. Uusitalo,et al.  Eight-year follow-up of photorefractive keratectomy for myopia. , 2004, Journal of refractive surgery.

[43]  R R Krueger,et al.  Quantitation of corneal ablation by ultraviolet laser light. , 1985, Archives of ophthalmology.

[44]  W. A. Lyle,et al.  Retreatment after initial laser in situ keratomileusis. , 2000, Journal of cataract and refractive surgery.

[45]  P. Condon 2005 ESCRS Ridley Medal Lecture: Will keratectasia be a major complication for LASIK in the long term? , 2006, Journal of cataract and refractive surgery.

[46]  A. Nizam,et al.  Age-related refractive shifts in simple myopia. , 1997, Journal of refractive surgery.

[47]  M. Macsai,et al.  Keratectasia after laser in situ keratomileusis: a histopathologic and immunohistochemical study. , 2008, Archives of ophthalmology.

[48]  S. Trokel,et al.  Excimer laser surgery of the cornea. , 1983, American journal of ophthalmology.

[49]  I. Pallikaris,et al.  Epi‐LASIK: Comparative histological evaluation of mechanical and alcohol‐assisted epithelial separation , 2003, Journal of cataract and refractive surgery.

[50]  D. Azar,et al.  Human corneal epithelial cell viability and morphology after dilute alcohol exposure. , 2002, Investigative ophthalmology & visual science.

[51]  P. Binder Ectasia after laser in situ keratomileusis , 2003, Journal of cataract and refractive surgery.

[52]  M. O'Keefe,et al.  Comparative study of higher-order aberrations after conventional laser in situ keratomileusis and laser epithelial keratomileusis for myopia using the technolas 217z laser platform. , 2009, American journal of ophthalmology.

[53]  C. McGhee,et al.  Safety and predictability of laser in situ keratomileusis enhancement by flap reelevation in high myopia , 2001, Journal of cataract and refractive surgery.

[54]  Aleksandar Stojanovic,et al.  Correlation between ultraviolet radiation level and the incidence of late‐onset corneal haze after photorefractive keratectomy , 2001, Journal of cataract and refractive surgery.

[55]  E. Balestrazzi,et al.  Photorefractive keratectomy and LASIK for the correction of hyperopia: 2-year follow-up. , 2006, Journal of refractive surgery.