Applications of Various Steric Constants to Quantitative Analysis of Structure-Activity Relationships

Structure-activity relationships for biologically active congeneric compounds were examined by using free-energy-related physicochemical parameters and regression technique. The steric effects involved in such biological activities were expressible and separable from other factors as steric parameters depending upon the situations. In this article, examples for enzyme reactions, enzyme inhibitions, insecticides, fungicides, herbicides, plant growth regulators and synthetic sweetners, mostly from our own laboratory are reviewed. The steric parameters used here are Taft Es, Hancock E s c , Verloop STERIMOL and van der Waals molar volume.

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