Structural differences among monoclonal antibodies with distinct fine specificities and kinetic properties.

[1]  S. Smith‐Gill,et al.  Experimental design for analysis of complex kinetics using surface plasmon resonance. , 2000, Methods.

[2]  C. Chothia,et al.  The atomic structure of protein-protein recognition sites. , 1999, Journal of molecular biology.

[3]  J. Kirsch,et al.  Kinetic epitope mapping of the chicken lysozyme.HyHEL‐10 fab complex: Delineation of docking trajectories , 1998, Protein science : a publication of the Protein Society.

[4]  Arvind Rajpal,et al.  Quantitative evaluation of the chicken lysozyme epitope in the HyHEL‐10 fab complex: Free energies and kinetics , 1998, Protein science : a publication of the Protein Society.

[5]  E. Goldman,et al.  A mutational analysis of binding interactions in an antigen-antibody protein-protein complex. , 1998, Biochemistry.

[6]  T. Manser,et al.  Single amino acid substitutions in V(H) CDR2 are sufficient to generate or enhance the specificity of two forms of an anti-arsonate antibody variable region for DNA. , 1997, Molecular immunology.

[7]  R C Stevens,et al.  Structural insights into the evolution of an antibody combining site. , 1997, Science.

[8]  G. Wagner,et al.  The counterreceptor binding site of human CD2 exhibits an extended surface patch with multiple conformations fluctuating with millisecond to microsecond motions , 1997, Protein science : a publication of the Protein Society.

[9]  M Ohlin,et al.  Selection of binders from phage displayed antibody libraries using the BIAcore biosensor. , 1996, Journal of immunological methods.

[10]  C. MacKenzie,et al.  Analysis by Surface Plasmon Resonance of the Influence of Valence on the Ligand Binding Affinity and Kinetics of an Anti-carbohydrate Antibody (*) , 1996, The Journal of Biological Chemistry.

[11]  R. Kelley,et al.  Analysis of the factor VIIa binding site on human tissue factor: effects of tissue factor mutations on the kinetics and thermodynamics of binding. , 1995, Biochemistry.

[12]  K Watanabe,et al.  Role of Tyr Residues in the Contact Region of Anti-lysozyme Monoclonal Antibody HyHEL10 for Antigen Binding (*) , 1995, The Journal of Biological Chemistry.

[13]  C. MacKenzie,et al.  Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene libraries. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Y. Kurosawa,et al.  Mutations in the complementarity-determining regions do not cause differences in free energy during the process of formation of the activated complex between an antibody and the corresponding protein antigen. , 1995, Journal of molecular biology.

[15]  M. Polymenis,et al.  Domain interactions and antigen binding of recombinant anti-Z-DNA antibody variable domains. The role of heavy and light chains measured by surface plasmon resonance. , 1995, Journal of immunology.

[16]  R M Zinkernagel,et al.  Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[17]  K Watanabe,et al.  Contribution to antibody-antigen interaction of structurally perturbed antigenic residues upon antibody binding. , 1994, The Journal of biological chemistry.

[18]  Y. Iba,et al.  Effects of substitutions of closely related amino acids at the contact surface in an antigen-antibody complex on thermodynamic parameters. , 1993, The Journal of biological chemistry.

[19]  R. Kelley,et al.  Thermodynamic analysis of an antibody functional epitope. , 1993, Biochemistry.

[20]  A. Wilson,et al.  High-resolution mapping of the HyHEL-10 epitope of chicken lysozyme by site-directed mutagenesis. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[21]  S. Smith‐Gill,et al.  Patterns of antibody specificity during the BALB/c immune response to hen eggwhite lysozyme. , 1992, Journal of immunology.

[22]  D. Benjamin,et al.  Long-range changes in a protein antigen due to antigen-antibody interaction. , 1992, Biochemistry.

[23]  G. Winter,et al.  Selection of phage antibodies by binding affinity. Mimicking affinity maturation. , 1992, Journal of molecular biology.

[24]  A. Fersht,et al.  The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding. , 1992, Journal of molecular biology.

[25]  G. Winter,et al.  Antibody framework residues affecting the conformation of the hypervariable loops. , 1992, Journal of molecular biology.

[26]  S. Smith‐Gill,et al.  Experimental analysis by site-directed mutagenesis of somatic mutation effects on affinity and fine specificity in antibodies specific for lysozyme. , 1992, Journal of immunology.

[27]  A. Fersht,et al.  Mapping transition states of protein unfolding by protein engineering of ligand-binding sites. , 1991, Journal of molecular biology.

[28]  C. Milstein,et al.  Kinetic maturation of an immune response , 1991, Nature.

[29]  R. Jemmerson,et al.  Common structural features among monoclonal antibodies binding the same antigenic region of cytochrome c. , 1991, The Journal of biological chemistry.

[30]  A. Fersht,et al.  Strength and co-operativity of contributions of surface salt bridges to protein stability. , 1990, Journal of molecular biology.

[31]  T. W. Fawcett,et al.  An effective method for eliminating "artifact banding" when sequencing double-stranded DNA templates. , 1990, BioTechniques.

[32]  L. J. Nell,et al.  VH and VL gene usage by murine IgG antibodies that bind autologous insulin. , 1990, Journal of immunology.

[33]  S. Smith‐Gill,et al.  A substantial proportion of the adult BALB/c available B cell repertoire consists of multireactive B cells. , 1989, Molecular immunology.

[34]  G. Cohen,et al.  Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[35]  P. Gearhart,et al.  Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response , 1989, The Journal of experimental medicine.

[36]  S. Smith‐Gill,et al.  Organ reactive autoantibodies from non-immunized adult BALB/c mice are polyreactive and express non-biased VH gene usage. , 1989, Molecular immunology.

[37]  E. Haber,et al.  Characterization of the heavy and light chain immunoglobulin variable region genes used in a set of anti-digoxin antibodies. , 1989, Molecular immunology.

[38]  C. Kocks,et al.  Stepwise intraclonal maturation of antibody affinity through somatic hypermutation. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[39]  M. Stenzel-Poore,et al.  The Adaptive Potential of the Memory Response: Clonal Recruitment and Epitope Recognition , 1988, Immunological reviews.

[40]  E. Padlan,et al.  Antibody-antigen complexes. , 1988, Annual review of biochemistry.

[41]  S. Smith‐Gill,et al.  Contributions of immunoglobulin heavy and light chains to antibody specificity for lysozyme and two haptens. , 1987, Journal of immunology.

[42]  A. Lesk,et al.  Canonical structures for the hypervariable regions of immunoglobulins. , 1987, Journal of molecular biology.

[43]  B. Brooks,et al.  A three-dimensional model of an anti-lysozyme antibody. , 1987, Journal of molecular biology.

[44]  I. Sanz,et al.  V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[45]  C. Janeway,et al.  Molecular characterization of antibodies bearing Id-460. I. The structure of two highly homologous VH genes used to produce idiotype positive immunoglobulins. , 1986, Journal of immunology.

[46]  C. Janeway,et al.  Molecular characterization of antibodies bearing Id-460. II. Molecular basis for Id-460 expression , 1985, The Journal of experimental medicine.

[47]  E. Chen,et al.  Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. , 1985, DNA.

[48]  K. Rajewsky,et al.  Somatic mutation and clonal expansion of B cells in an antigen‐driven immune response. , 1985, The EMBO journal.

[49]  K. Rajewsky,et al.  Molecular basis of an isogeneic anti‐idiotypic response. , 1984, The EMBO journal.

[50]  David Baltimore,et al.  Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells , 1984, Nature.

[51]  J. D. Capra,et al.  Junctional diversity is essential to antibody activity. , 1984, Journal of immunology.

[52]  S. Smith‐Gill,et al.  Antigenic regions defined by monoclonal antibodies correspond to structural domains of avian lysozyme. , 1984, Journal of immunology.

[53]  R. Near,et al.  Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[54]  D. Kelso,et al.  Particle concentration fluorescence immunoassay (PCFIA): a new, rapid immunoassay technique with high sensitivity. , 1984, Journal of immunological methods.

[55]  S. Rudikoff,et al.  VL-VH expression by monoclonal antibodies recognizing avian lysozyme. , 1984, Journal of immunology.

[56]  B. Hoffman,et al.  A simple and very efficient method for generating cDNA libraries. , 1983, Gene.

[57]  D. Hanahan.  Studies on transformation of Escherichia coli with plasmids. , 1983, Journal of molecular biology.

[58]  E. Haber,et al.  Classification of mouse VK groups based on the partial amino acid sequence to the first invariant tryptophan: impact of 14 new sequences from IgG myeloma proteins. , 1982, Molecular immunology.

[59]  F. Alt,et al.  Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[60]  A. Wilson,et al.  Mapping the antigenic epitope for a monoclonal antibody against lysozyme. , 1982, Journal of immunology.

[61]  S. Tonegawa,et al.  Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments , 1982, The Journal of experimental medicine.

[62]  P. Ross,et al.  Thermodynamics of protein association reactions: forces contributing to stability. , 1981, Biochemistry.

[63]  J V Maizel,et al.  The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes. , 1981, The Journal of biological chemistry.

[64]  L. Hood,et al.  Immunoglobulins with hapten‐binding activity: structure‐function correlations and genetic implications , 1978, European journal of immunology.

[65]  E. Padlan,et al.  Localized deletion-insertion mutations: a major factor in the evolution of immunoglobulin structural variability. , 1976, Journal of immunology.

[66]  J. Kirsch,et al.  Energetic analysis of an antigen/antibody interface: Alanine scanning mutagenesis and double mutant cycles on the hyhel‐10/lysozyme interaction , 1999, Protein science : a publication of the Protein Society.

[67]  E. Kabat,et al.  Sequences of proteins of immunological interest , 1991 .

[68]  A. Wilson,et al.  17 – Analysis of Antibody-Protein Interactions Utilizing Site-Directed Mutagenesis and a New Evolutionary Variant of Lysozyme , 1990 .

[69]  I. Sanz,et al.  The molecular genetics of the arsonate idiotypic system of A/J mice. , 1988, Advances in immunology.

[70]  B. Diamond,et al.  Somatic mutation alters affinity and specificity. , 1985, Annales de l'Institut Pasteur. Immunologie.

[71]  E. Chen,et al.  Supercoil sequencing: a fast method for sequencing plasmid DNA , 1985 .

[72]  R. Riblet,et al.  The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes , 1984, European journal of immunology.

[73]  C. Milstein,et al.  mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification , 1983, Nature.

[74]  J. Martial,et al.  A method for isolation of intact, translationally active ribonucleic acid. , 1983, DNA.

[75]  M. Potter.  Immunoglobulins and Immunoglobulin Genes , 1983 .

[76]  W. Gilbert,et al.  Sequencing end-labeled DNA with base-specific chemical cleavages. , 1980, Methods in enzymology.