Biologically Sensitive Field Effect Devices using Polysilicon TFTs

This paper presents a review of recent developments in the detection of biomolecular interactions with field-effect devices. Ion-sensitive field-effect transistors (ISFETs) and enzyme field-effect transistors (EnFETs), based on polycrystalline silicon (poly-Si) TFTs, are discussed. Label-free electrical detection of DNA hybridization has been achieved by a new method, by using MOS capacitors or poly-Si TFTs. The method can in principle be extended to other chemical or biochemical systems, such as proteins and cells.