Leukemia Bearing a Novel t ( 8 ; 14 ) ( q 24 ; qll ) Translocation Demonstrates Spontaneous In Vitro Natural Killer-Like Activity

A highly malignant human T-cell leukemia was identified by cell surface analysis as a member of the T-cell receptor (TCR) yS lineage. Cytogenetic and molecular analysis showed a novel t(8;14)(q24;qll) rearrangement involving the J,, gene segment on chromosome 14 and the distal end of chromosome 8 near the c-myc proto-oncogene locus. The yS TCR of the leukemia blasts was functionally intact and could be activated to generate intracellular calcium flux and to target Fc receptor-mediated redirected tumor cell lysis. In addition,

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