论文信息 - APPLICATION OF SOLID-STATE KINETICS TO DESOLVATION REACTIONS

APPLICATION OF SOLID-STATE KINETICS TO DESOLVATION REACTIONS

The book presents an overview of the solid-state kinetic literature including methodologies used, mathematical derivations and pharmaceutical applications. The book investigates the relationship between calculation methods and artifactual results observed in solid-state kinetics. A new approach is proposed for evaluating solid-state kinetic data, this approach combines modelistic and model-free methods in a complimentary manner to achieve consistent kinetic results. Experimental data focused on studying the solid-state stability of several structurally related solvates of sulfameter (5–methoxysulfadiazine), this was done by studying the kinetics of their desolvation reaction both isothermally and nonisothermally. Calculated kinetic parameters were compared and related to the crystal structure of these solvates. A relationship was established between desolvation kinetic parameters (e.g., activation energy) and the solvent size. The solid-state reaction models selected also corresponded to the single crystal structure of the sulfameter-solvate system.

Ammar Khawam | Ammar Khawam

[1] K. Morris. STRUCTURAL ASPECTS OF HYDRATES AND SOLVATES , 1999 .

[2] C. F. Curtiss,et al. Molecular Theory Of Gases And Liquids , 1954 .

[3] Michael Montagne,et al. Pharmaceutical Statistics: Practical and Clinical Applications , 1985 .

[4] E. E. Carpenter,et al. Solid–Solid Reactions , 2007 .

[5] M. E. Brown,et al. Reactions in the solid state , 2006 .

[6] William L. Hase,et al. Chemical kinetics and dynamics , 1989 .

[7] G. Höhne,et al. Differential Scanning Calorimetry , 2007 .

[8] H. C. Van De Hulst,et al. 2 – Exponential Integrals and Related Functions , 1980 .

[9] J. T. Carstensen,et al. Drug stability : principles and practices , 1995 .

[10] S. Byrn. Solid state chemistry of drugs , 1982 .

[11] A C C Gibbs,et al. Data Analysis , 2009, Encyclopedia of Database Systems.

[12] M. E. Brown,et al. Introduction to Thermal Analysis , 1988 .

[13] J. Guillory. GENERATION OF POLYMORPHS, HYDRATES, SOLVATES, AND AMORPHOUS SOLIDS , 1999 .

[14] W. Garner. Chemistry of the solid state , 1955 .

[15] Sanford Bolton. Pharmaceutical statistics: Practical and clinical applications , 1984 .

[16] W. Wendlandt. Thermal analysis. , 1986, Analytical chemistry.

[17] M. E. Brown,et al. Introduction to Thermal Analysis: Techniques and applications , 1988 .