Understanding racial disparities in cancer treatment and outcomes.

o p p f r 2 w i t t t recent report from the Institute of Medicine documents idespread racial disparities in medical treatment and ealth outcomes. Such disparities are particularly apparent mong patients with cancer. For many types of cancer, lack Americans have markedly higher cancer-specific ortality rates than members of other racial and ethnic roups—more than 2-fold higher in some instances. Exess cancer mortality in this group is partly attributable to igher cancer incidence rates. However, increased cancer ortality among black patients is also due in large part to orse prognoses among those already diagnosed. Reasons for higher mortality among minorities encomass both patient factors and provider and health care sysem effects. Patient factors include characteristics associted with decreased longevity, such as socioeconomic status SES), health behaviors, and comorbid conditions. At the rovider level, higher cancer mortality may reflect underse of screening, resulting in later stage at diagnosis, and nderuse of cancer-directed surgery and adjuvant therapy. inally, racial disparities may be associated with differences n the quality of care delivered by providers and by the elected settings where black patients cluster for care. Some f these settings have been associated with higher cancer ortality rates and may be less likely to provide high uality comprehensive, transitional, and follow-up care afer surgery.

[1]  T. Laveist Disentangling race and socioeconomic status: A key to understanding health inequalities , 2005, Journal of Urban Health.

[2]  A. Nattinger,et al.  The influence of black race and socioeconomic status on the use of breast‐conserving surgery for medicare beneficiaries , 1997, Cancer.

[3]  A. Jemal,et al.  Cancer Statistics, 2009 , 2009, CA: a cancer journal for clinicians.

[4]  Hosmer,et al.  Medicare treatment differences for blacks and whites. , 1997, Medical care.

[5]  C. Redmond,et al.  Prognosis among African‐American women and white women with lymph node negative breast carcinoma , 1997, Cancer.

[6]  M. Campbell,et al.  Colorectal cancer screening among African American church members: A qualitative and quantitative study of patient-provider communication , 2004, BMC public health.

[7]  D. Schrag,et al.  Missed opportunities: racial disparities in adjuvant breast cancer treatment. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  V. Shavers,et al.  Race/ethnicity and the receipt of watchful waiting for the initial management of prostate cancer , 2004, Journal of General Internal Medicine.

[9]  M. Menon,et al.  Factors contributing to the racial differences in prostate cancer mortality , 2005, BJU international.

[10]  H. Freeman,et al.  Expanding access to cancer screening and clinical follow-up among the medically underserved. , 1995, Cancer practice.

[11]  D. Wickerham,et al.  Outcomes among African-Americans and Caucasians in colon cancer adjuvant therapy trials: findings from the National Surgical Adjuvant Breast and Bowel Project. , 1999, Journal of the National Cancer Institute.

[12]  J. Mandelblatt,et al.  Patient navigation: State of the art or is it science? , 2008, Cancer.

[13]  D. Nerenz,et al.  Comorbidity and survival disparities among black and white patients with breast cancer. , 2005, JAMA.

[14]  T. Eberlein Hospital Factors and Racial Disparities in Mortality After Surgery for Breast and Colon Cancer , 2011 .

[15]  J. Birkmeyer,et al.  Surgeon volume and operative mortality in the United States. , 2003, The New England journal of medicine.

[16]  A. Elixhauser,et al.  Treatment differences between blacks and whites with colorectal cancer. , 1996, Medical care.

[17]  Kevin Fiscella,et al.  Evaluating the cost‐effectiveness of cancer patient navigation programs: Conceptual and practical issues , 2009, Cancer.

[18]  David R. Williams Race/Ethnicity and Socioeconomic Status: Measurement and Methodological Issues , 1996, International journal of health services : planning, administration, evaluation.

[19]  C. Bradley,et al.  Disparities in cancer diagnosis and survival , 2001, Cancer.

[20]  C B Begg,et al.  Racial differences in the treatment of early-stage lung cancer. , 1999, The New England journal of medicine.

[21]  R. Coates,et al.  Patterns and predictors of colorectal cancer test use in the adult U.S. population , 2004, Cancer.

[22]  C. Redmond,et al.  Determinants of black/white differences in colon cancer survival. , 1995, Journal of the National Cancer Institute.

[23]  A. Stewart,et al.  Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation. , 2005, JAMA.

[24]  P. Walsh Survival of blacks and whites after a cancer diagnosis. , 2002, The Journal of urology.

[25]  Laura-Mae Baldwin,et al.  Residual treatment disparities after oncology referral for rectal cancer. , 2008, Journal of the National Cancer Institute.

[26]  G. Silvestri,et al.  Underuse of surgical resection for localized, non-small cell lung cancer among whites and African Americans in South Carolina. , 2008, The Annals of thoracic surgery.

[27]  M. Banerjee,et al.  Race, socioeconomic status and stage at diagnosis for five common malignancies , 2003, Cancer Causes & Control.

[28]  E. McCarthy,et al.  Factors associated with colon cancer screening: the role of patient factors and physician counseling. , 2005, Preventive medicine.

[29]  Kathryn E. McGoldrick,et al.  Surgeon Volume and Operative Mortality in the United States , 2004 .

[30]  D. Chu,et al.  Patient attitudes towards chemotherapy as assessed by patient versus physician: a prospective observational study in advanced non-small cell lung cancer. , 2007, Lung cancer.

[31]  Hegang Chen,et al.  Racial disparity in primary hepatocellular carcinoma: tumor stage at presentation, surgical treatment and survival. , 2006, Journal of the National Medical Association.

[32]  M. Zinner,et al.  Race and Surgical Outcomes: It Is Not All Black and White , 2008, Annals of surgery.

[33]  F. Spitz,et al.  Underuse of esophagectomy as treatment for resectable esophageal cancer. , 2008, Archives of surgery.

[34]  J. Birkmeyer,et al.  Socioeconomic Status and Surgical Mortality in the Elderly , 2008, Medical care.

[35]  Edward L Spitznagel,et al.  Prognostic importance of comorbidity in a hospital-based cancer registry. , 2004, JAMA.

[36]  D. Wennberg,et al.  Hospital-Level Racial Disparities in Acute Myocardial Infarction Treatment and Outcomes , 2005, Medical care.

[37]  P. Roderick,et al.  Inequalities in survival from colorectal cancer: a comparison of the impact of deprivation, treatment, and host factors on observed and cause specific survival , 2003, Journal of epidemiology and community health.

[38]  J. Birkmeyer,et al.  Race and Surgical Mortality in the United States , 2006, Annals of surgery.

[39]  S. Murphy,et al.  Ethnicity and attitudes towards life sustaining technology. , 1999, Social science & medicine.

[40]  W. Levinson,et al.  A study of patient clues and physician responses in primary care and surgical settings. , 2000, JAMA.

[41]  P. Kvale,et al.  Evaluation of the causes for racial disparity in surgical treatment of early stage lung cancer. , 2006, Chest.

[42]  D. Schrag,et al.  Using navigators to improve care of underserved patients , 2005, Cancer.

[43]  C. Flowers,et al.  Racial variation in colorectal polyp and tumor location. , 2007, Journal of the National Medical Association.

[44]  C. Begg,et al.  Influence of hospital procedure volume on outcomes following surgery for colon cancer. , 2000, JAMA.

[45]  A Milstein,et al.  Selective referral to high-volume hospitals: estimating potentially avoidable deaths. , 2000, JAMA.

[46]  W. Barlow,et al.  Explaining black-white differences in receipt of recommended colon cancer treatment. , 2005, Journal of the National Cancer Institute.

[47]  N. Wolmark,et al.  Prognosis after rectal cancer in blacks and whites participating in adjuvant therapy randomized trials. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[48]  K. Armstrong,et al.  Differences in treatment and outcome between African-American and white women with endometrial cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[49]  C. Lynch,et al.  Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[50]  D. Ball,et al.  Differences of opinion: a survey of knowledge and bias among clinicians regarding the role of chemotherapy in metastatic non-small cell lung cancer. , 2004, Chest.

[51]  A. Morris,et al.  Adjuvant Radiation for Rectal Cancer: Do We Measure Up to the Standard of Care? An Epidemiologic Analysis of Trends Over 25 Years in the United States , 2005, Diseases of the colon and rectum.

[52]  R. Cooper,et al.  Socioeconomic Status and Health in Blacks and Whites: The Problem of Residual Confounding and the Resiliency of Race , 1997, Epidemiology.

[53]  A. Jha,et al.  Quality of colon cancer outcomes in hospitals with a high percentage of Medicaid patients. , 2008, Journal of the American College of Surgeons.

[54]  W. Levinson,et al.  Communication between surgeons and patients in routine office visits. , 1999, Surgery.

[55]  Xianglin L. Du,et al.  Racial disparities and treatment trends in a large cohort of elderly black and white patients with nonsmall cell lung cancer , 2009, Cancer.

[56]  Louie E. Ross,et al.  Physician-patient discussions about prostate-specific antigen test use among African-American men. , 2006, Journal of the National Medical Association.

[57]  C. Shields,et al.  Attitudes toward life-sustaining interventions among ambulatory black and white patients. , 2006, Ethnicity & disease.

[58]  K A Schulman,et al.  The effect of race and sex on physicians' recommendations for cardiac catheterization. , 1999, The New England journal of medicine.

[59]  R. Levine,et al.  Racial disparities and trends in use of colorectal procedures among Tennessee elderly (1996-2000). , 2006, Ethnicity & disease.

[60]  C. Earle,et al.  Racial differences in surgical evaluation, treatment, and outcome of locoregional esophageal cancer: a population-based analysis of elderly patients. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[61]  D. Asch,et al.  Racial Profiling: The Unintended Consequences of Coronary Artery Bypass Graft Report Cards , 2005, Circulation.

[62]  F. Hopp,et al.  Racial Variations in End‐of‐Life Care , 2000, Journal of the American Geriatrics Society.

[63]  G. Cooper,et al.  Racial disparities in the use of and indications for colorectal procedures in Medicare beneficiaries , 2004, Cancer.

[64]  G. Smith,et al.  Learning to live with complexity: ethnicity, socioeconomic position, and health in Britain and the United States. , 2000, American journal of public health.

[65]  C. Ko,et al.  A Patient's Race/Ethnicity Does Not Explain the Underuse of Appropriate Adjuvant Therapy in Colorectal Cancer , 2006, Diseases of the colon and rectum.

[66]  Adrienne Y. Stith,et al.  Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care , 2005 .

[67]  J. Birkmeyer,et al.  Racial disparities in late survival after rectal cancer surgery. , 2006, Journal of the American College of Surgeons.

[68]  S. Arday,et al.  HCFA's Racial and Ethnic Data: Current Accuracy and Recent Improvements , 2000, Health care financing review.

[69]  J. Birkmeyer,et al.  Hospital volume and surgical mortality in the United States. , 2002, The New England journal of medicine.

[70]  Deborah Schrag,et al.  Primary care physicians who treat blacks and whites. , 2004, The New England journal of medicine.