SERUM URIC ACID LEVEL AS AN EARLY PROGNOSTIC INDICATOR IN PATIENTS WITH ACUTE CORONARY SYNDROME

Background: Cardiovascular disease (CVD) is a leading cause of death globally, with 80% of cases occurring in low and middle-income countries. The study aims to implicate the elevation of serum uric acid in acute coronary syndrome and to assess the prognostic significance of serum uric acid in patients with acute coronary syndrome. Materials and Methods: This prospective observational study was conducted for six months at Rajiv Gandhi Government General Hospital (RGGGH), Chennai. One hundred patients were selected based on inclusion and exclusion criteria, informed consent and ethical approval obtained, detailed history taking and clinical examination, ECG recording, serum levels of cardiac biomarkers, Killip Class of all patients, and serum levels of Uric acid. Results: Most cases were in the 51-60 age group (48%) and least represented by those between 71 and 80 years. There is no significant difference in gender, age, hypertension, and diabetes between groups. Serum uric acid level at day 0 was significantly higher in cases than in controls. The correlation between SUA levels on day 0 and Killip Class on day 5 is significant, but not between Killip Class on day 0 and Killip Class on day 5. The mean serum uric acid values on admission were 6.8 ± 2.68, with 23 patients of Killip Class 1. On day five, the mean serum uric acid level was 5.6 ± 1.2 for Killip Class 1. Conclusion: Serum uric acid is an inexpensive risk factor and prognostic marker for assessing short-term adverse outcomes in patients with ACS.