Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein.

[1]  Xavier Deupi,et al.  Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II , 2011, Proceedings of the National Academy of Sciences.

[2]  K. Palczewski,et al.  Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. , 2011, Journal of structural biology.

[3]  M. J. Chalmers,et al.  Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX. , 2011, Structure.

[4]  Virgil L. Woods,et al.  Conformational changes in the G protein Gs induced by the β2 adrenergic receptor , 2011, Nature.

[5]  K. Palczewski,et al.  Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. , 2011, Progress in lipid research.

[6]  G. Salgado,et al.  Solid-state 2H NMR relaxation illuminates functional dynamics of retinal cofactor in membrane activation of rhodopsin , 2011, Proceedings of the National Academy of Sciences.

[7]  K. Palczewski,et al.  Role of Bulk Water in Hydrolysis of the Rhodopsin Chromophore* , 2011, The Journal of Biological Chemistry.

[8]  Oliver P. Ernst,et al.  Crystal structure of metarhodopsin II , 2011, Nature.

[9]  Gebhard F. X. Schertler,et al.  The structural basis of agonist-induced activation in constitutively active rhodopsin , 2011, Nature.

[10]  G. Salgado,et al.  Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation , 2011, Nature Structural &Molecular Biology.

[11]  Lars Konermann,et al.  Hydrogen exchange mass spectrometry for studying protein structure and dynamics. , 2011, Chemical Society reviews.

[12]  S. Rasmussen,et al.  Structure of a nanobody-stabilized active state of the β2 adrenoceptor , 2010, Nature.

[13]  K. Palczewski.  Oligomeric forms of G protein-coupled receptors (GPCRs). , 2010, Trends in biochemical sciences.

[14]  F. Fleuret,et al.  Cross Section and Parity Violating Spin Asymmetries of W^+/- Boson Production in Polarized p+p Collisions at sqrt(s)=500 GeV , 2010, 1009.0505.

[15]  M. Chance,et al.  Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry. , 2010, Structure.

[16]  K. Palczewski,et al.  Complexes between photoactivated rhodopsin and transducin: progress and questions. , 2010, The Biochemical journal.

[17]  Tod D Romo,et al.  A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor* , 2010, The Journal of Biological Chemistry.

[18]  M. Chance,et al.  Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. , 2010, Biochemistry.

[19]  M. J. Chalmers,et al.  Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange. , 2010, Analytical chemistry.

[20]  M. Chance,et al.  Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. , 2010, Structure.

[21]  M. Chance,et al.  Integrated algorithms for high-throughput examination of covalently labeled biomolecules by structural mass spectrometry. , 2009, Analytical chemistry.

[22]  Mark R. Chance,et al.  Structural waters define a functional channel mediating activation of the GPCR, rhodopsin , 2009, Proceedings of the National Academy of Sciences.

[23]  Krzysztof Palczewski,et al.  Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors , 2009, Proceedings of the National Academy of Sciences.

[24]  Hua Xu,et al.  Automated diagnosis of LC-MS/MS performance , 2009, Bioinform..

[25]  Michael A. Freitas,et al.  MassMatrix: A database search program for rapid characterization of proteins and peptides from tandem mass spectrometry data , 2009, Proteomics.

[26]  A. Engel,et al.  Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[27]  K. Palczewski,et al.  Different properties of the native and reconstituted heterotrimeric G protein transducin. , 2008, Biochemistry.

[28]  Oliver P. Ernst,et al.  Crystal structure of opsin in its G-protein-interacting conformation , 2008, Nature.

[29]  M. Pitman,et al.  Internal hydration increases during activation of the G-protein-coupled receptor rhodopsin. , 2008, Journal of molecular biology.

[30]  K. Palczewski,et al.  Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. , 2008, Annual review of pharmacology and toxicology.

[31]  Manfred Burghammer,et al.  Crystal structure of a thermally stable rhodopsin mutant. , 2007, Journal of molecular biology.

[32]  Guozhong Xu,et al.  Hydroxyl radical-mediated modification of proteins as probes for structural proteomics. , 2007, Chemical reviews.

[33]  W. Baumeister,et al.  Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography , 2007, The Journal of cell biology.

[34]  Krzysztof Palczewski,et al.  Crystal packing analysis of Rhodopsin crystals. , 2007, Journal of structural biology.

[35]  D. Oprian,et al.  Transducin Activation by Nanoscale Lipid Bilayers Containing One and Two Rhodopsins* , 2007, Journal of Biological Chemistry.

[36]  M. Chance,et al.  The Beamline X28C of the Center for Synchrotron Biosciences: a national resource for biomolecular structure and dynamics experiments using synchrotron footprinting. , 2007, Journal of synchrotron radiation.

[37]  Richard N. Zare,et al.  A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein , 2007, Proceedings of the National Academy of Sciences.

[38]  Hua Xu,et al.  A mass accuracy sensitive probability based scoring algorithm for database searching of tandem mass spectrometry data , 2007, BMC Bioinformatics.

[39]  M. Engelhard,et al.  Interaction of a G protein-coupled receptor with a G protein-derived peptide induces structural changes in both peptide and receptor: a Fourier-transform infrared study using isotopically labeled peptides. , 2007, Journal of molecular biology.

[40]  T. Okada,et al.  X‐Ray Crystallographic Analysis of 9‐cis‐Rhodopsin, a Model Analogue Visual Pigment † , 2007, Photochemistry and photobiology.

[41]  J. Ballesteros,et al.  Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals. , 2006, Journal of structural biology.

[42]  J. R. Engen,et al.  Semi-automated data processing of hydrogen exchange mass spectra using HX-Express , 2006, Journal of the American Society for Mass Spectrometry.

[43]  Krzysztof Palczewski,et al.  Crystal structure of a photoactivated deprotonated intermediate of rhodopsin , 2006, Proceedings of the National Academy of Sciences.

[44]  T. Okada,et al.  Local peptide movement in the photoreaction intermediate of rhodopsin , 2006, Proceedings of the National Academy of Sciences.

[45]  D. Oprian,et al.  Recoverin Binds Exclusively to an Amphipathic Peptide at the N Terminus of Rhodopsin Kinase, Inhibiting Rhodopsin Phosphorylation without Affecting Catalytic Activity of the Kinase* , 2006, Journal of Biological Chemistry.

[46]  T. Okada,et al.  Crystallographic analysis of primary visual photochemistry. , 2006, Angewandte Chemie.

[47]  Krzysztof Palczewski,et al.  G protein-coupled receptor rhodopsin. , 2006, Annual review of biochemistry.

[48]  A. Engel,et al.  Functional and Structural Characterization of Rhodopsin Oligomers* , 2006, Journal of Biological Chemistry.

[49]  K. Palczewski,et al.  Rhodopsin self-associates in asolectin liposomes. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[50]  K. Palczewski,et al.  Diversifying the repertoire of G protein-coupled receptors through oligomerization. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[51]  M. Chance,et al.  Radiolytic modification of sulfur-containing amino acid residues in model peptides: fundamental studies for protein footprinting. , 2005, Analytical chemistry.

[52]  T. Okada.  X-ray crystallographic studies for ligand-protein interaction changes in rhodopsin. , 2004, Biochemical Society transactions.

[53]  R. Cerione,et al.  Perturbing the linker regions of the alpha-subunit of transducin: a new class of constitutively active GTP-binding proteins. , 2004, The Journal of biological chemistry.

[54]  Marcus Elstner,et al.  The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. , 2004, Journal of molecular biology.

[55]  A. Engel,et al.  The G protein‐coupled receptor rhodopsin in the native membrane , 2004, FEBS letters.

[56]  Manfred Burghammer,et al.  Structure of bovine rhodopsin in a trigonal crystal form. , 2003, Journal of molecular biology.

[57]  Guozhong Xu,et al.  Radiolytic modification of basic amino acid residues in peptides: probes for examining protein-protein interactions. , 2003, Analytical chemistry.

[58]  A. Engel,et al.  Atomic-force microscopy: Rhodopsin dimers in native disc membranes , 2003, Nature.

[59]  K. Palczewski,et al.  Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor , 2002, Chembiochem : a European journal of chemical biology.

[60]  D C Teller,et al.  Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). , 2001, Biochemistry.

[61]  K. Palczewski,et al.  X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. , 2000, Journal of structural biology.

[62]  H. Khorana,et al.  Structural features of the C-terminal domain of bovine rhodopsin: a site-directed spin-labeling study. , 1999, Biochemistry.

[63]  H. Khorana,et al.  Structure and function in rhodopsin: topology of the C-terminal polypeptide chain in relation to the cytoplasmic loops. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[64]  R. Cerione,et al.  A C-terminal peptide of bovine rhodopsin binds to the transducin alpha-subunit and facilitates its activation. , 1994, The Biochemical journal.

[65]  Edgar Meyer,et al.  Internal water molecules and H‐bonding in biological macromolecules: A review of structural features with functional implications , 1992, Protein science : a publication of the Protein Society.

[66]  K. Palczewski,et al.  Mechanism of rhodopsin kinase activation. , 1991, The Journal of biological chemistry.

[67]  P. A. Fortes,et al.  Rhodopsin in reconstituted phospholipid vesicles. 2. Rhodopsin-rhodopsin interactions detected by resonance energy transfer. , 1983, Biochemistry.

[68]  D. Baylor,et al.  Responses of retinal rods to single photons. , 1979, The Journal of physiology.

[69]  I. Huhtaniemi,et al.  From the Cover: Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation , 2010 .

[70]  Michael A. Freitas,et al.  Identification and characterization of disulfide bonds in proteins and peptides from tandem MS data by use of the MassMatrix MS/MS search engine. , 2008, Journal of proteome research.

[71]  Clare E. M. Stevenson,et al.  Structural Biology and Crystallization Communications Crystallization and Preliminary X-ray Analysis of the O-methyltransferase Novp from the Novobiocin- Biosynthetic Cluster of Streptomyces Spheroides , 2007 .

[72]  R. Armstrong,et al.  Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry. , 2005, Archives of biochemistry and biophysics.

[73]  M. Chance,et al.  RADIOLYTIC MODIFICATION OF ACIDIC AMINO ACIDS: NEW PROBES OF PROTEIN FOOTPRINTING , 2004 .

[74]  M. Chance,et al.  Radiolytic modification of acidic amino acid residues in peptides: probes for examining protein-protein interactions. , 2003, Analytical chemistry.

[75]  D. Papermaster.  Preparation of retinal rod outer segments. , 1982, Methods in enzymology.