Killing of target cells due to radon progeny in the human lung.

The dose conversion coefficient (DCC) is used to assess the risk due to inhaled radon progeny in the human lung. The present work uses the microdosimetric approach and determines the linear energy transfer in the target cell nuclei. Killing of target cells was also taken into account through an effect-specific track length model. To focus on the relevant part of the absorbed dose in the cell nuclei, the absorbed dose, which causes cell-killing is discarded in the final calculations of the DCC. Following this approach, the calculated DCC has become 3.4 mSv WLM(-1) which is very close to the epidemiologically derived value of approximately 4 mSv WLM(-1).

[1]  W. Hofmann,et al.  Interaction of alpha particles at the cellular level--implications for the radiation weighting factor. , 2004, Radiation protection dosimetry.

[2]  J. Stather.  Dosimetric and epidemiological approaches to assessing radon doses--can the differences be reconciled? , 2004, Radiation protection dosimetry.

[3]  D. Nikezić,et al.  ROOM MODEL WITH THREE MODAL DISTRIBUTIONS OF ATTACHED RADON PROGENY , 2004, Health physics.

[4]  D. Nikezić,et al.  Absorbed fraction of alpha-particles emitted in bifurcation regions of the human tracheo-bronchial tree , 2003, Radiation and environmental biophysics.

[5]  D. Nikezić,et al.  Absorbed fraction of radon progeny in human bronchial airways with bifurcation geometry , 2003, International journal of radiation biology.

[6]  X Ortega,et al.  Uncertainty analysis of the weighted equivalent lung dose per unit exposure to radon progeny in the home. , 2002, Radiation protection dosimetry.

[7]  D. Nikezić,et al.  Effects of different deposition models on the calculated dose conversion factors from 222Rn progeny. , 2002, Journal of environmental radioactivity.

[8]  D. Crawford‐Brown,et al.  Correlated hit probability and cell transformation in an effect-specific track length model applied to in vitro alpha irradiation , 2001, Radiation and environmental biophysics.

[9]  D. Nikezić,et al.  Microdosimetric calculation of absorption fraction and the resulting dose conversion factor for radon progeny , 2001, Radiation and environmental biophysics.

[10]  D. Nikezić,et al.  Radon progeny dose conversion coefficients for Chinese males and females. , 2001, Journal of environmental radioactivity.

[11]  D. Crawford‐Brown,et al.  Modeling energy deposition and cellular radiation effects in human bronchial epithelium by radon progeny alpha particles. , 2000, Health physics.

[12]  J. Marsh,et al.  Sensitivity Analysis of the Weighted Equivalent Lung Dose Per Unit Exposure from Radon Progeny , 2000 .

[13]  D. Nikezić,et al.  Effects of different lung morphometry models on the calculated dose conversion factor from Rn progeny , 2000 .

[14]  J. Crapo,et al.  Radon dosimetry based on the depth distribution of nuclei in human and rat lungs. , 1991, Health physics.

[15]  D. Crawford‐Brown,et al.  An effect-specific track-length model for radiations of intermediate to high LET. , 1991, Radiation research.