Extra-nuclear activity of INSM1 transcription factor enhances insulin receptor signaling pathway and Nkx6.1 expression through RACK1 interaction.

[1]  M. Breslin,et al.  Functional role of an islet transcription factor, INSM1/IA‐1, on pancreatic acinar cell trans‐differentiation , 2012, Journal of cellular physiology.

[2]  M. Breslin,et al.  Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation. , 2010, Endocrinology.

[3]  C. Weitz,et al.  Identification of RACK1 and Protein Kinase Cα as Integral Components of the Mammalian Circadian Clock , 2010, Science.

[4]  M. Breslin,et al.  Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest* , 2009, Journal of Biological Chemistry.

[5]  M. Pollak,et al.  Insulin and insulin-like growth factor signalling in neoplasia , 2008, Nature Reviews Cancer.

[6]  N. Chao Faculty Opinions recommendation of In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. , 2008 .

[7]  Douglas A. Melton,et al.  In vivo reprogramming of adult pancreatic exocrine cells to β-cells , 2008, Nature.

[8]  D. Stoffers,et al.  On the origin of the beta cell. , 2008, Genes & development.

[9]  M. Breslin,et al.  Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription. , 2008, The Journal of endocrinology.

[10]  M. Beckerle,et al.  Characterization of RACK1 function in Drosophila development , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[11]  M. Breslin,et al.  Neurogenin 3 recruits CBP co‐activator to facilitate histone H3/H4 acetylation in the target gene INSM1 , 2007, FEBS letters.

[12]  C. Birchmeier,et al.  The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. , 2006, Genes & development.

[13]  M. Breslin,et al.  INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. , 2006, The Biochemical journal.

[14]  R. F. Luco,et al.  IA1 is NGN3‐dependent and essential for differentiation of the endocrine pancreas , 2006, The EMBO journal.

[15]  J. D. Engel,et al.  MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion , 2005, Molecular and Cellular Biology.

[16]  D. Neal,et al.  The Scaffolding Protein RACK1 Interacts with Androgen Receptor and Promotes Cross-talk through a Protein Kinase C Signaling Pathway* , 2003, Journal of Biological Chemistry.

[17]  M. Breslin,et al.  NeuroD1/E47 Regulates the E-box Element of a Novel Zinc Finger Transcription Factor, IA-1, in Developing Nervous System* , 2003, Journal of Biological Chemistry.

[18]  H. Hamm,et al.  The βγ Subunit of Heterotrimeric G Proteins Interacts with RACK1 and Two Other WD Repeat Proteins* , 2002, The Journal of Biological Chemistry.

[19]  R. O'Connor,et al.  RACK1 Is an Insulin-like Growth Factor 1 (IGF-1) Receptor-interacting Protein That Can Regulate IGF-1-mediated Akt Activation and Protection from Cell Death* , 2002, The Journal of Biological Chemistry.

[20]  Weiqun Li,et al.  RACK1, an Insulin-Like Growth Factor I (IGF-I) Receptor-Interacting Protein, Modulates IGF-I-Dependent Integrin Signaling and Promotes Cell Spreading and Contact with Extracellular Matrix , 2002, Molecular and Cellular Biology.

[21]  M. Breslin,et al.  Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. , 2002, Nucleic acids research.

[22]  Y. Zick Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. , 2001, Trends in cell biology.

[23]  L. Sussel,et al.  Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. , 2000, Development.

[24]  H. Watada,et al.  Transcriptional and Translational Regulation of β-Cell Differentiation Factor Nkx6.1* , 2000, The Journal of Biological Chemistry.

[25]  A. Usacheva,et al.  Receptor for Activated C-Kinase (RACK-1), a WD Motif-Containing Protein, Specifically Associates with the Human Type I IFN Receptor1 , 2000, The Journal of Immunology.

[26]  L. Sussel,et al.  Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. , 2000, Development.

[27]  F. Guillemot,et al.  neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[28]  B. Ursø,et al.  The α‐isoform of class II phosphoinositide 3‐kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs , 1999 .

[29]  S. Govoni,et al.  The role of anchoring protein rack1 in pkc activation in the ageing rat brain , 1997, Trends in Neurosciences.

[30]  M. de Silva,et al.  A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs. , 1992, The Journal of biological chemistry.

[31]  H. Hamm,et al.  The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. , 2002, The Journal of biological chemistry.

[32]  William L. Clarke,et al.  Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence , 1997, Nature Genetics.

[33]  H. Grosse [Diabetes and cancer]. , 1956, Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten.