EAST: Energy Alignment Search Tool

The inspection of structural changes (in selected proteins' regions) that take place in particular reactions of signal pathways is very important for their analysis. Conformational modifications as an effect of biochemical reactions or environmental influences cause changes in the conformational energy distributions. Observations of the energy characteristics allow to detect structural changes of selected proteins. In the paper, we present the EAST – method of similarity searching based on energy profiles. This method can be employed to find similar proteins during the analysis of substrates of signal paths' reactions and to detect regions of protein structure modifications.

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