Gastrin in gastrointestinal diseases.

[1]  W. Suarez-Pinzon,et al.  Combination Therapy with a Dipeptidyl Peptidase-4 Inhibitor and a Proton Pump Inhibitor Induces β-Cell Neogenesis from Adult Human Pancreatic Duct Cells Implanted in Immunodeficient Mice , 2011, Cell transplantation.

[2]  J. Rehfeld,et al.  The Zollinger-Ellison syndrome and mismeasurement of gastrin. , 2011, Gastroenterology.

[3]  M. Ocak,et al.  Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 , 2011, European Journal of Nuclear Medicine and Molecular Imaging.

[4]  M. Jong,et al.  Comparison of the binding and internalization properties of 12 DOTA-coupled and 111In-labelled CCK2/gastrin receptor binding peptides: a collaborative project under COST Action BM0607 , 2011, European Journal of Nuclear Medicine and Molecular Imaging.

[5]  W. Oyen,et al.  Comparative biodistribution of 12 111In-labelled gastrin/CCK2 receptor-targeting peptides , 2011, European Journal of Nuclear Medicine and Molecular Imaging.

[6]  J. Rehfeld,et al.  Incretin physiology beyond glucagon‐like peptide 1 and glucose‐dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides , 2011, Acta physiologica.

[7]  K. Hajjar,et al.  Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells. , 2011, Gastroenterology.

[8]  P. Sexton,et al.  Allosteric modulation of G protein-coupled receptors: A pharmacological perspective , 2011, Neuropharmacology.

[9]  M. Guilhaus,et al.  Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion , 2010, Proceedings of the National Academy of Sciences.

[10]  A. Lohse,et al.  CCK1 and CCK2 Receptors Are Expressed on Pancreatic Stellate Cells and Induce Collagen Production , 2010, The Journal of Biological Chemistry.

[11]  C. Seva,et al.  Cell surface F1-ATPase binds the Gastrin precursor, G-gly, and mediates its proliferative effects on colorectal cancer cells and vascular endothelial cells , 2010, Regulatory Peptides.

[12]  G. Baldwin,et al.  Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine. , 2010, American journal of physiology. Gastrointestinal and liver physiology.

[13]  D. Corley,et al.  Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients. , 2010, Gastroenterology.

[14]  T. Wang,et al.  A gastrin precursor, gastrin‐gly, upregulates VEGF expression in colonic epithelial cells through an HIF‐1‐independent mechanism , 2010, International journal of cancer.

[15]  I. Drozdov,et al.  The CCK2 receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development , 2010, Regulatory Peptides.

[16]  W. Tsai,et al.  Elevated Serum Gastrin Is Associated With a History of Advanced Neoplasia in Barrett's Esophagus , 2010, The American Journal of Gastroenterology.

[17]  J. Merchant,et al.  Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. , 2010, Gastroenterology.

[18]  F. Hollande,et al.  Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. , 2010, Gastroenterology.

[19]  T. Wang,et al.  Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. , 2009, The Journal of clinical investigation.

[20]  A. Mason,et al.  Definition of the residues required for the interaction between glycine‐extended gastrin and transferrin in vitro , 2009, The FEBS journal.

[21]  T. Graham,et al.  Long-term proton pump induced hypergastrinaemia does induce lineage-specific restitution but not clonal expansion in benign Barrett's oesophagus in vivo , 2009, Gut.

[22]  F. Hollande,et al.  The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells. , 2009, Cancer research.

[23]  C. Reimer,et al.  Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. , 2009, Gastroenterology.

[24]  G. Sauter,et al.  Impaired gastric acidification negatively affects calcium homeostasis and bone mass , 2009, Nature Medicine.

[25]  E. Krenning,et al.  Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma , 2009, European Journal of Nuclear Medicine and Molecular Imaging.

[26]  G. Baldwin,et al.  Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth. , 2009, Biochimica et biophysica acta.

[27]  M. Atkinson,et al.  Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice , 2008, Diabetes.

[28]  J. Neoptolemos,et al.  Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. , 2008, Gastroenterology.

[29]  G. Baldwin,et al.  Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors. , 2007, Gastroenterology.

[30]  E. Marco,et al.  Mechanism of Activation of a G Protein-coupled Receptor, the Human Cholecystokinin-2 Receptor* , 2007, Journal of Biological Chemistry.

[31]  L. Friis-Hansen.  Lessons from the gastrin knockout mice , 2007, Regulatory Peptides.

[32]  P. Singh,et al.  Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells , 2007, Oncogene.

[33]  S. Watson,et al.  Gastrin — active participant or bystander in gastric carcinogenesis? , 2006, Nature Reviews Cancer.

[34]  L. Samuelson,et al.  Differentiation of the gastric mucosa. II. Role of gastrin in gastric epithelial cell proliferation and maturation. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[35]  Kelly A. Smith,et al.  Production, secretion, and biological activity of the C-terminal flanking peptide of human progastrin. , 2006, Gastroenterology.

[36]  C. Seva,et al.  Cholecystokinin and gastrin receptors. , 2006, Physiological reviews.

[37]  J. Rehfeld.  The endoproteolytic maturation of progastrin and procholecystokinin , 2006, Journal of Molecular Medicine.

[38]  M. Béhé,et al.  CCK-2/gastrin receptor-targeted tumor imaging with (99m)Tc-labeled minigastrin analogs. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[39]  T. Wang,et al.  Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors. , 2005, Cancer research.

[40]  N. Uedo,et al.  Evidence that Loss of Sonic Hedgehog is an Indicator of Helicobater pylori-induced Atrophic Gastritis Progressing to Gastric Cancer , 2005, The American Journal of Gastroenterology.

[41]  T. Wang,et al.  COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo. , 2005, American journal of physiology. Gastrointestinal and liver physiology.

[42]  G. Baldwin,et al.  Gastrins, cholecystokinins and gastrointestinal cancer. , 2004, Biochimica et biophysica acta.

[43]  T. Wood,et al.  Intestinal expression of mutant and wild‐type progastrin significantly increases colon carcinogenesis in response to azoxymethane in transgenic mice , 2004, Cancer.

[44]  L. Mazzucchelli,et al.  High expression of peptide receptors as a novel target in gastrointestinal stromal tumours , 2004, European Journal of Nuclear Medicine and Molecular Imaging.

[45]  Yazhou Li,et al.  Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene. , 2003, Gastroenterology.

[46]  R. Herranz.  Cholecystokinin antagonists: Pharmacological and therapeutic potential , 2003, Medicinal research reviews.

[47]  H. Friess,et al.  Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue. , 2003, Gastroenterology.

[48]  J. Reubi,et al.  Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[49]  G. Baldwin,et al.  Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells , 2003, Journal of Cell Science.

[50]  R. Norton,et al.  Ferric Ions Are Essential for the Biological Activity of the Hormone Glycine-extended Gastrin* , 2002, The Journal of Biological Chemistry.

[51]  B. Maigret,et al.  Structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists. , 2002, Pharmacology & toxicology.

[52]  L. Tessarollo,et al.  Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice. , 2002, Gastroenterology.

[53]  T. Wang,et al.  Expression of CCK2 receptors in the murine pancreas: proliferation, transdifferentiation of acinar cells, and neoplasia. , 2002, Gastroenterology.

[54]  B. Ji,et al.  Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. , 2001, Gastroenterology.

[55]  G. Baldwin,et al.  Involvement of Phosphatidylinositol 3-Kinase and Mitogen-activated Protein Kinases in Glycine-extended Gastrin-induced Dissociation and Migration of Gastric Epithelial Cells* , 2001, The Journal of Biological Chemistry.

[56]  G. Baldwin,et al.  Short term infusion of glycine‐extended gastrin17 stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa , 2001, International journal of cancer.

[57]  A. Paterson,et al.  Biologically Active Recombinant Human Progastrin6–80Contains a Tightly Bound Calcium Ion* , 2001, The Journal of Biological Chemistry.

[58]  T. Wang,et al.  Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. , 2000, The Journal of clinical investigation.

[59]  T. Wang,et al.  Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. , 2000, Gastroenterology.

[60]  E. Krenning,et al.  Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma , 2000, European Journal of Nuclear Medicine.

[61]  J. Rehfeld,et al.  Closing the gastrin loop in pancreatic carcinoma , 2000, Cancer.

[62]  S. Kelly,et al.  Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma , 2000, Gut.

[63]  N. Tarasova,et al.  Evidence for a functional role of the cholecystokinin-B/gastrin receptor in the human fetal and adult pancreas. , 1999, Diabetes.

[64]  A. Todisco,et al.  Glycine-extended gastrin regulates HEK cell growth. , 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

[65]  M. Béhé,et al.  Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors. , 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[66]  J. Laissue,et al.  Receptor autoradiographic evaluation of cholecystokinin, neurotensin, somatostatin and vasoactive intestinal peptide receptors in gastro‐intestinal adenocarcinoma samples: Where are they really located? , 1999, International journal of cancer.

[67]  T. Wang,et al.  Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. , 1999, The Journal of clinical investigation.

[68]  A. Todisco,et al.  Glycine-Extended Gastrin Exerts Growth-Promoting Effects on Human Colon Cancer Cells , 1999, Molecular medicine.

[69]  J. Erion,et al.  Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo , 1998, European Journal of Nuclear Medicine.

[70]  G. Ciccotosto,et al.  Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line. , 1997, Gastroenterology.

[71]  T. Wang,et al.  Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. , 1997, Gastroenterology.

[72]  H. J. Kim,et al.  Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. , 1997, Gastroenterology.

[73]  A. Kowalski-Chauvel,et al.  Tyrosine phosphorylation of insulin receptor substrate-1 and activation of the PI-3-kinase pathway by glycine-extended gastrin precursors. , 1997, Biochemical and biophysical research communications.

[74]  J. Rehfeld,et al.  Expression of gastrin and transforming growth factor-α during duct to islet cell differentiation in the pancreas of duct-ligated adult rats , 1997, Diabetologia.

[75]  J. Merchant,et al.  EGF receptor activation stimulates endogenous gastrin gene expression in canine G cells and human gastric cell cultures. , 1997, The Journal of clinical investigation.

[76]  B. Waser,et al.  Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors. , 1997, Cancer research.

[77]  A. Sandvik,et al.  Marked increase in gastric acid secretory capacity after omeprazole treatment. , 1996, Gut.

[78]  T. Wang,et al.  Processing and proliferative effects of human progastrin in transgenic mice. , 1996, The Journal of clinical investigation.

[79]  J C Reubi,et al.  Unexpected high incidence of cholecystokinin‐B/gastrin receptors in human medullary thyroid carcinomas , 1996, International journal of cancer.

[80]  J. Gordon,et al.  Diphtheria Toxin-mediated Ablation of Parietal Cells in the Stomach of Transgenic Mice (*) , 1996, The Journal of Biological Chemistry.

[81]  A. Todisco,et al.  Gastrin and Glycine-extended Progastrin Processing Intermediates Induce Different Programs of Early Gene Activation (*) , 1995, The Journal of Biological Chemistry.

[82]  G. Ciccotosto,et al.  Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. , 1995, Gastroenterology.

[83]  C. Seva,et al.  Growth-promoting effects of glycine-extended progastrin. , 1994, Science.

[84]  E. Rozengurt,et al.  CCKA and CCKB receptors are expressed in small cell lung cancer lines and mediate Ca2+ mobilization and clonal growth. , 1993, Cancer research.

[85]  E. Schmidt,et al.  Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. , 1993, The Journal of clinical investigation.

[86]  I. Sobhani,et al.  Chronic endogenous hypergastrinemia in humans: evidence for a mitogenic effect on the colonic mucosa. , 1993, Gastroenterology.

[87]  R. Koski,et al.  Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. , 1993, Cancer research.

[88]  W. Creutzfeldt,et al.  Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis. , 1993, Gastroenterology.

[89]  J. Rehfeld,et al.  Expression but incomplete maturation of progastrin in colorectal carcinomas. , 1993, Gastroenterology.

[90]  G. Dockray,et al.  Identification of progastrin derived peptides in colorectal carcinoma extracts. , 1993, Gut.

[91]  P. Correa,et al.  Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. , 1992, Cancer research.

[92]  J. Merchant,et al.  A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter , 1991, Molecular and cellular biology.

[93]  L. Bardram,et al.  Progastrin in serum from Zollinger-Ellison patients. An indicator of malignancy? , 1990, Gastroenterology.

[94]  F. Sundler,et al.  Proposed mechanism of induction of gastric carcinoids: the gastrin hypothesis , 1990, European journal of clinical investigation.

[95]  Pomila Singh,et al.  Clinical significance of gastrin receptors in human colon cancers. , 1989, Cancer research.

[96]  B. Marshall,et al.  PROSPECTIVE DOUBLE-BLIND TRIAL OF DUODENAL ULCER RELAPSE AFTER ERADICATION OF CAMPYLOBACTER PYLORI , 1988, The Lancet.

[97]  J. Del Valle,et al.  Progastrin and its glycine-extended posttranslational processing intermediates in human gastrointestinal tissues. , 1987, Gastroenterology.

[98]  S. Pauwels,et al.  Identification of progastrin in gastrinomas, antrum, and duodenum by a novel radioimmunoassay. , 1986, The Journal of clinical investigation.

[99]  J. Rehfeld,et al.  Disturbed islet-cell function related to endogenous gastrin release. Studies on insulin secretion and glucose tolerance in pernicious anemia. , 1976, The Journal of clinical investigation.

[100]  V. Mutt,et al.  Structure of Porcine Cholecystokinin‐Pancreozymin , 1968 .

[101]  J. Morley,et al.  Structure–Function Relationships in the Active C-Terminal Tetrapeptide Sequence of Gastrin , 1965, Nature.

[102]  R A GREGORY,et al.  The constitution and properties of two gastrins extracted from hog antral mucosa , 1964, Gut.

[103]  J. S. Edkins.  The chemical mechanism of gastric secretion 1 , 1906 .

[104]  G. Baldwin,et al.  Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas , 2005, Journal of Cancer Research and Clinical Oncology.

[105]  U. Yallampalli,et al.  pp60c-Src Kinase mediates growth effects of the full-length precursor progastrin1-80 peptide on rat intestinal epithelial cells, in vitro. , 2003, Endocrinology.

[106]  T. Wang,et al.  The gastrins: their production and biological activities. , 2001, Annual review of physiology.

[107]  T. Wang,et al.  Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. , 2000, Gastroenterology.

[108]  K. Lloyd,et al.  5 Gut hormones in gastric function , 1994 .

[109]  J. Rehfeld,et al.  Progastrin expression in mammalian pancreas. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[110]  L. Ekman,et al.  Enterochromaffin-like cell carcinoids in the rat gastric mucosa following long-term administration of ranitidine. , 1990, Digestion.

[111]  Tumorigenesis and Neoplastic Progression Gastrin Is an Essential Cofactor for Helicobacter- Associated Gastric Corpus Carcinogenesis in C57BL/6 Mice , 2022 .