Healing Effects of Ginsenoside Rg1 on Experimental Open Wound in Rat

This study was performed to investigate the effect of ginsenoside Rg1 treatment on wound healing using SD rats by generating four full-thickness skin wounds on the dorsum. In the Rg1-treated groups (5,000 and 10,000 ppm), area of wounds and macroscopic inflammatory signs were significantly decreased compared to control group throughout the experimental period in a concentration dependent manner. Histological appearance after 20 days of treatment with Rg1 revealed the formation of epithelial layer, hair follicles and progressive angiogenesis and an increase in collagen and granulation as compared to control group. Rg1 treatment resulted in the increased expression of the vascular endothelial growth factor (VEGF) mRNA and reduced expression of transforming growth factor beta (TGF-β) mRNA in wounded skin compared to control group. The expression levels of VEGF and TGF-β mRNA in the Rg1-treated groups were similar to those of Fucidin® ointment-treated group. These results suggested that Rg1 should be helpful for the promotion of wound healing.

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