Research Update: Materials design of implantable nanogenerators for biomechanical energy harvesting

Implantable nanogenerators are rapidly advanced recently as a promising concept for harvesting biomechanical energy in vivo. This review article presents an overview of the most current progress of implantable piezoelectric nanogenerator (PENG) and triboelectric nanogenerator (TENG) with a focus on materials selection, engineering, and assembly. The evolution of the PENG materials is discussed from ZnO nanostructures, to high-performance ferroelectric perovskites, to flexible piezoelectric polymer mesostructures. Discussion of TENGs is focused on the materials and surface features of friction layers, encapsulation materials, and device integrations. Challenges faced by this promising technology and possible future research directions are also discussed.

[1]  Wei Zhang,et al.  Implantable and self-powered blood pressure monitoring based on a piezoelectric thinfilm: Simulated, in vitro and in vivo studies , 2016 .

[2]  Ping Zhao,et al.  Sponge‐Like Piezoelectric Polymer Films for Scalable and Integratable Nanogenerators and Self‐Powered Electronic Systems , 2014 .

[3]  Long Lin,et al.  A Flexible, Stretchable and Shape‐Adaptive Approach for Versatile Energy Conversion and Self‐Powered Biomedical Monitoring , 2015, Advanced materials.

[4]  Jan M. Rabaey,et al.  Improving power output for vibration-based energy scavengers , 2005, IEEE Pervasive Computing.

[5]  Jinhui Song,et al.  Integrated nanogenerators in biofluid. , 2007, Nano letters.

[6]  E. Meng,et al.  MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications. , 2012, Advanced drug delivery reviews.

[7]  Thad Starner,et al.  Human-Powered Wearable Computing , 1996, IBM Syst. J..

[8]  H. Wada,et al.  Piezoelectric materials mimic the function of the cochlear sensory epithelium , 2011, Proceedings of the National Academy of Sciences.

[9]  Fan Liao,et al.  Recent Advancements in Nanogenerators for Energy Harvesting. , 2015, Small.

[10]  Peihua Zhang,et al.  A flexible piezoelectric force sensor based on PVDF fabrics , 2011 .

[11]  Zhong Lin Wang,et al.  Cellular level biocompatibility and biosafety of ZnO nanowires , 2008 .

[12]  Zhe Wang,et al.  Wireless, power-free and implantable nanosystem for resistance-based biodetection , 2015 .

[13]  Chang Kyu Jeong,et al.  Self‐Powered Cardiac Pacemaker Enabled by Flexible Single Crystalline PMN‐PT Piezoelectric Energy Harvester , 2014, Advanced materials.

[14]  Vikramaditya G. Yadav,et al.  Cell and protein compatibility of parylene-C surfaces. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[15]  Yang Zou,et al.  Biodegradable triboelectric nanogenerator as a life-time designed implantable power source , 2016, Science Advances.

[16]  Weibo Cai,et al.  Biocompatibility and in vivo operation of implantable mesoporous PVDF-based nanogenerators. , 2016, Nano energy.

[17]  Vivek Y. Reddy,et al.  Leadless Cardiac Pacemakers: Back to the Future. , 2015, Journal of the American College of Cardiology.

[18]  Fan Yang,et al.  In Vivo Self-Powered Wireless Cardiac Monitoring via Implantable Triboelectric Nanogenerator. , 2016, ACS nano.

[19]  Eun Kyung Lee,et al.  Porous PVDF as effective sonic wave driven nanogenerators. , 2011, Nano letters.

[20]  Xi Chen,et al.  1.6 V nanogenerator for mechanical energy harvesting using PZT nanofibers. , 2010, Nano letters.

[21]  Liwei Lin,et al.  Direct-write piezoelectric polymeric nanogenerator with high energy conversion efficiency. , 2010, Nano letters.

[22]  Zhong Lin Wang,et al.  Hybrid nanogenerator for concurrently harvesting biomechanical and biochemical energy. , 2010, ACS nano.

[23]  Chunhua Yao,et al.  Mesoporous Piezoelectric Polymer Composite Films with Tunable Mechanical Modulus for Harvesting Energy from Liquid Pressure Fluctuation , 2016, Advanced functional materials.

[24]  M. Bélanger,et al.  Hemocompatibility, biocompatibility, inflammatory and in vivo studies of primary reference materials low-density polyethylene and polydimethylsiloxane: a review. , 2001, Journal of biomedical materials research.

[25]  John A Rogers,et al.  Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm , 2014, Proceedings of the National Academy of Sciences.

[26]  R Guidoin,et al.  Polyvinylidene fluoride (PVDF) as a biomaterial: from polymeric raw material to monofilament vascular suture. , 1995, Journal of biomedical materials research.

[27]  Zhong Lin Wang,et al.  Progress in triboelectric nanogenerators as a new energy technology and self-powered sensors , 2015 .

[28]  Mihai Irimia-Vladu,et al.  "Green" electronics: biodegradable and biocompatible materials and devices for sustainable future. , 2014, Chemical Society reviews.

[29]  Xudong Wang,et al.  Piezoelectric nanogenerators—Harvesting ambient mechanical energy at the nanometer scale , 2012 .

[30]  G. Zhu,et al.  Muscle‐Driven In Vivo Nanogenerator , 2010, Advanced materials.

[31]  Yi Qi,et al.  Nanotechnology-enabled flexible and biocompatible energy harvesting , 2010 .

[32]  Jian Shi,et al.  PVDF microbelts for harvesting energy from respiration , 2011 .

[33]  Michael C. McAlpine,et al.  Piezoelectric ribbons printed onto rubber for flexible energy conversion. , 2010, Nano letters.

[34]  A Heller,et al.  Implanted electrochemical glucose sensors for the management of diabetes. , 1999, Annual review of biomedical engineering.

[35]  Zhong Lin Wang,et al.  Self-powered nanotech. , 2008, Scientific American.

[36]  Zhong Lin Wang,et al.  Power generation with laterally packaged piezoelectric fine wires. , 2009, Nature nanotechnology.

[37]  Xue Feng,et al.  Ultra-flexible Piezoelectric Devices Integrated with Heart to Harvest the Biomechanical Energy , 2015, Scientific Reports.

[38]  Zhong Lin Wang.  Triboelectric nanogenerators as new energy technology for self-powered systems and as active mechanical and chemical sensors. , 2013, ACS nano.

[39]  Zhong Lin Wang,et al.  Piezoelectric Nanogenerators Based on Zinc Oxide Nanowire Arrays , 2006, Science.

[40]  J. Langberg,et al.  Survival after implantation of the cardioverter defibrillator. , 1992, The American journal of cardiology.

[41]  Qi Xu,et al.  Electrospinning lead-free 0.5Ba(Zr0.2Ti0.8)O3–0.5(Ba0.7Ca0.3)TiO3 nanowires and their application in energy harvesting , 2013 .

[42]  Chih-Ming Ho,et al.  Surface molecular property modifications for poly(dimethylsiloxane) (PDMS) based microfluidic devices , 2009, Microfluidics and nanofluidics.

[43]  Ren Zhu,et al.  High Output Piezoelectric Nanogenerator: Development and Application , 2012 .

[44]  Mohan V. Jacob,et al.  Implantable devices: issues and challenges , 2012 .

[45]  Ningsheng Xu,et al.  Dissolving Behavior and Stability of ZnO Wires in Biofluids: A Study on Biodegradability and Biocompatibility of ZnO Nanostructures , 2006 .

[46]  Zhong Lin Wang,et al.  A universal self-charging system driven by random biomechanical energy for sustainable operation of mobile electronics , 2015, Nature Communications.

[47]  Hollis G. Potter,et al.  Author Manuscript , 2013 .

[48]  Jin Liu,et al.  Piezoelectric Nanogenerators for Self-Powered Nanodevices , 2008, IEEE Pervasive Computing.

[49]  Jie Wang,et al.  Sustainably powering wearable electronics solely by biomechanical energy , 2016, Nature Communications.

[50]  Steve Dunn,et al.  Piezoelectric nanogenerators – a review of nanostructured piezoelectric energy harvesters , 2015 .

[51]  Yang Liu,et al.  A flexible and implantable piezoelectric generator harvesting energy from the pulsation of ascending aorta: in vitro and in vivo studies , 2015 .

[52]  K. MacVittie,et al.  A pacemaker powered by an implantable biofuel cell operating under conditions mimicking the human blood circulatory system--battery not included. , 2013, Physical chemistry chemical physics : PCCP.

[53]  Yang Zou,et al.  Self-Powered, One-Stop, and Multifunctional Implantable Triboelectric Active Sensor for Real-Time Biomedical Monitoring. , 2016, Nano letters.

[54]  Guang Zhu,et al.  Converting biomechanical energy into electricity by a muscle-movement-driven nanogenerator. , 2009, Nano letters.

[55]  M. Chiao,et al.  Anti-fouling Coatings of Poly(dimethylsiloxane) Devices for Biological and Biomedical Applications , 2015, Journal of Medical and Biological Engineering.

[56]  Michael L. Levy,et al.  Vagus Nerve Stimulation , 2008, Proceedings of the IEEE.

[57]  Sihong Wang,et al.  In Vivo Powering of Pacemaker by Breathing‐Driven Implanted Triboelectric Nanogenerator , 2014, Advanced materials.

[58]  Qi Xu,et al.  Biocompatible Nanogenerators through High Piezoelectric Coefficient 0.5Ba(Zr0.2Ti0.8)O3‐0.5(Ba0.7Ca0.3)TiO3 Nanowires for In‐Vivo Applications , 2014, Advanced materials.

[59]  Zhong Lin Wang,et al.  Flexible triboelectric generator , 2012 .

[60]  Christopher R. Bowen,et al.  Piezoelectric and ferroelectric materials and structures for energy harvesting applications , 2014 .

[61]  Jiangxue Wang,et al.  Implantable Self-Powered Low-Level Laser Cure System for Mouse Embryonic Osteoblasts' Proliferation and Differentiation. , 2015, ACS nano.

[62]  Zhong Lin Wang,et al.  Transparent triboelectric nanogenerators and self-powered pressure sensors based on micropatterned plastic films. , 2012, Nano letters.

[63]  Jin Ho Kim,et al.  Surface modification of poly(dimethylsiloxane) microchannels , 2003, Electrophoresis.