Leptin , Anti-HSP 60 , Anti-HSP 65 and Anti-oxLDL in Autoimmune Rheumatic Diseases

To investigate whether leptin, heat shock proteins (HSP), oxidized lowdensity lipoprotein (oxLDL) are involved in the autoimmune rheumatic diseases (AIRD). We studied sera of 47 patients with vasculitis, 38 patients with Sjögren’s syndrome (SS), 44 patients with systemic sclerosis (SSc) and 154 sex-matched healthy subjects (HS). Serum leptin, autoantibody against (anti-) HSP60, HSP65 and oxLDL were determined by EIA. The level of leptin was increased in male patients with vasculitis (p<0.05), anti-HSP60 in all patient groups was lower (p<0.05) and anti-oxLDL was higher in SScpatients (p<0.05) than HS. We conclude that levels of serum leptin, antiHSP60, anti-HSP65 and anti-oxLDL multiply varied in vasculitis-patients, SS-patients and SSc-patients. These non-traditional factors are probably involved in the process of AIRD.

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