Precipitative Coating of Calcium Phosphate on Microporous Silica–Titania Hybrid Particles in Simulated Body Fluid

Titania and silica have been recognized as potential drug delivery system (DDS) carriers. For this application, controllable biocompatibility and the suppression of the initial burst are required, which can be provided by a calcium phosphate (CP) coating. However, it is difficult to control the morphology of a CP coating on the surface of carrier particles owing to the homogeneous nucleation of CP. In this study, we report the development of a CP-coating method that homogeneously corresponds to the shapes of silica–titania (SiTi) porous nanoparticles. We also demonstrate that controlled surface roughness of CP coatings could be achieved in SBF using SiTi nanoparticles with a well-defined spherical shape, a uniform size, and a tunable nanoporous structure. The precipitation of CP was performed on mono-dispersed porous SiTi nanoparticles with different Si/Ti molar ratios and pore sizes. The pore size distribution was found to significantly affect the CP coating in SBF immersion; the surfaces of the nanoparticles with bimodal pore sizes of 0.7 and 1.1–1.2 nm became rough after CP precipitation, while those with a unimodal pore size of 0.7 nm remained smooth, indicating that these two pore sizes serve as different nucleation sites that lead to different surface morphologies.

[1]  T. Kataoka,et al.  Preparation of Monodispersed Nanoporous Eu(III)/Titania Loaded with Ibuprofen: Optimum Loading, Luminescence, and Sustained Release. , 2021, Inorganic Chemistry.

[2]  M. Tagaya,et al.  Design of oriented mesoporous silica films for guiding protein adsorption states. , 2021, Journal of materials chemistry. B.

[3]  Xiaohong Jiang,et al.  Formation of Porous Apatite Layer after Immersion in SBF of Fluorine-Hydroxyapatite Coatings by Pulsed Laser Deposition Improved in Vitro Cell Proliferation , 2020 .

[4]  A. Garcia‐Bennett,et al.  Antioxidant properties of probucol released from mesoporous silica. , 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[5]  Shota Yamada,et al.  Synthesis of Spherical Phosphorus-Containing Mesoporous Silica for Improving their Reaction Behavior in Simulated Body Fluid , 2018, Key Engineering Materials.

[6]  P. Taberna,et al.  Ion Sieving Effects in Chemically Tuned Pillared Graphene Materials for Electrochemical Capacitors , 2018 .

[7]  Shota Yamada,et al.  Hybrid preparation of terbium(III)-doped mesoporous silica particles with calcium phosphates , 2017 .

[8]  R. Patel,et al.  Titania coated silica nanocomposite prepared via encapsulation method for the degradation of Safranin-O dye from aqueous solution: Optimization using statistical design , 2016 .

[9]  Jens Gruber,et al.  Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids , 2016, Journal of Sol-Gel Science and Technology.

[10]  F. Baldini,et al.  Sol-Gel-Based Titania-Silica Thin Film Overlay for Long Period Fiber Grating-Based Biosensors. , 2015, Analytical chemistry.

[11]  J. P. Olivier,et al.  Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report) , 2015 .

[12]  A. Barfeie,et al.  Implant surface characteristics and their effect on osseointegration , 2015, BDJ.

[13]  D. Wismeijer,et al.  UvA-DARE ( Digital Academic Repository ) A review paper on biomimetic calcium phosphate coatings , 2015 .

[14]  Sumit Kumar,et al.  Sorption of Eu(III) by amorphous titania, anatase and rutile: Denticity difference in surface complexes , 2013 .

[15]  Dusan Losic,et al.  Ultrasound enhanced release of therapeutics from drug-releasing implants based on titania nanotube arrays. , 2013, International journal of pharmaceutics.

[16]  M. Ogawa,et al.  Preparation of well-defined titania–silica spherical particles , 2012 .

[17]  J. Addai-Mensah,et al.  A multi-drug delivery system with sequential release using titania nanotube arrays. , 2012, Chemical communications.

[18]  E. Kauppinen,et al.  Aerosol-processed polymeric drug nanoparticles for sustained and triggered drug release. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[19]  Márcia M Marques,et al.  Analysis in vitro of the cytotoxicity of potential implant materials. I: Zirconia-titania sintered ceramics. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[20]  María Vallet-Regí,et al.  Sol-gel silica-based biomaterials and bone tissue regeneration. , 2010, Acta biomaterialia.

[21]  Min Zhu,et al.  The three-stage in vitro degradation behavior of mesoporous silica in simulated body fluid , 2010 .

[22]  N. Dahotre,et al.  Wettability and kinetics of hydroxyapatite precipitation on a laser-textured Ca-P bioceramic coating. , 2009, Acta biomaterialia.

[23]  Chaoliang He,et al.  Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release , 2009 .

[24]  J. Eriksson,et al.  Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems. , 2009, Nano letters.

[25]  A. Sandhu,et al.  Preparation of spherical and uniform-sized ferrite nanoparticles with diameters between 50 and 150 nm for biomedical applications , 2009 .

[26]  D. Zhao,et al.  Superparamagnetic high-magnetization microspheres with an Fe3O4@SiO2 core and perpendicularly aligned mesoporous SiO2 shell for removal of microcystins. , 2008, Journal of the American Chemical Society.

[27]  Jackie Y. Ying,et al.  Synthesis of water-soluble and functionalized nanoparticles by silica coating , 2007 .

[28]  Silvia Panzavolta,et al.  Nanocrystalline hydroxyapatite coatings on titanium: a new fast biomimetic method. , 2005, Biomaterials.

[29]  Yuhan Sun,et al.  Comparative study of sol–gel-hydrothermal and sol–gel synthesis of titania–silica composite nanoparticles , 2005 .

[30]  E. Hunziker,et al.  Osteoinductive Implants: The Mise-en-scène for Drug-Bearing Biomimetic Coatings , 2004, Annals of Biomedical Engineering.

[31]  J. Jansen,et al.  Electrostatic spray deposition (ESD) of calcium phosphate coatings. , 2003, Journal of biomedical materials research. Part A.

[32]  J. Jansen,et al.  In vivo dissolution behavior of various RF magnetron-sputtered Ca-P coatings on roughened titanium implants. , 2003, Biomaterials.

[33]  Zhi Zheng,et al.  Synthesis and Characterization of Phosphated Mesoporous Titanium Dioxide with High Photocatalytic Activity , 2003 .

[34]  K. Khor,et al.  In vitro studies of plasma-sprayed hydroxyapatite/Ti-6Al-4V composite coatings in simulated body fluid (SBF). , 2003, Biomaterials.

[35]  S. R. Kim,et al.  Synthesis of Si, Mg substituted hydroxyapatites and their sintering behaviors. , 2003, Biomaterials.

[36]  F. Cui,et al.  A simple biomimetic method for calcium phosphate coating , 2002 .

[37]  C. V. van Blitterswijk,et al.  Osteoclastic resorption of biomimetic calcium phosphate coatings in vitro. , 2001, Journal of biomedical materials research.

[38]  D. Aurbach,et al.  Ion sieving effects in the electrical double layer of porous carbon electrodes: Estimating effective ion size in electrolytic solutions , 2001 .

[39]  J. Jansen,et al.  IN-VIVO DISSOLUTION BEHAVIOR OF VARIOUS RF MAGNETRON SPUTTERED CA-P COATINGS ON ROUGHENED TITANIUM IMPLANTS , 1999 .

[40]  J. Jansen,et al.  In vivo dissolution behavior of various RF magnetron sputtered Ca-P coatings. , 1998, Journal of biomedical materials research.

[41]  M Tanahashi,et al.  Surface functional group dependence on apatite formation on self-assembled monolayers in a simulated body fluid. , 1997, Journal of biomedical materials research.

[42]  S C Soderholm,et al.  Role of the alveolar macrophage in lung injury: studies with ultrafine particles. , 1992, Environmental health perspectives.

[43]  N. Fujii,et al.  FT-IR liquid attenuated total reflection study of TiO2SiO2 sol-gel reaction , 1991 .

[44]  T Kitsugi,et al.  Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. , 1990, Journal of biomedical materials research.

[45]  Huang Fuqiang,et al.  Removal of Volatile Organic Compounds Driven by Platinum Supported on Amorphous Phosphated Titanium Oxide , 2019, Journal of Inorganic Materials.

[46]  C. Sfeir,et al.  Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition. , 2013, Acta biomaterialia.

[47]  Feng Yang,et al.  Differential mouse pulmonary dose and time course responses to titanium dioxide nanospheres and nanobelts. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[48]  G. Dias,et al.  Calcium phosphate coatings on magnesium alloys for biomedical applications: a review. , 2012, Acta biomaterialia.

[49]  K. Kaneko,et al.  A Molecular Simulation Study on Empirical Determination Method of Pore Structures of Activated Carbons , 1998 .

[50]  Alexander Wokaun,et al.  Porous silica gels and TiO2/SiO2 mixed oxides prepared via the sol-gel process: characterization by spectroscopic techniques , 1992 .

[51]  P. Ducheyne,et al.  Plasma spraying induced changes of calcium phosphate ceramic characteristics and the effect onin vitro stability , 1992 .

[52]  K. Sing,et al.  Adsorptive properties of microporous carbons: primary and secondary micropore filling , 1984 .

[53]  S. Brunauer,et al.  Investigations of a complete pore structure analysis , 1968 .