BCL-XL directly modulates RAS signalling to favour cancer cell stemness

[1]  Chih-Yang Wang,et al.  Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells , 2015, Nature.

[2]  C. Spits,et al.  Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL. , 2014, Molecular human reproduction.

[3]  Elgene Lim,et al.  Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. , 2013, Cancer cell.

[4]  P. Juin,et al.  Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival , 2013, Cell cycle.

[5]  Y. Okada,et al.  HMGA2 is a driver of tumor metastasis. , 2013, Cancer research.

[6]  Philippe Juin,et al.  Decoding and unlocking the BCL-2 dependency of cancer cells , 2013, Nature Reviews Cancer.

[7]  John G. Albeck,et al.  Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. , 2013, Molecular cell.

[8]  Travis J Cohoon,et al.  Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. , 2013, Cancer cell.

[9]  Steven J. M. Jones,et al.  Comprehensive molecular portraits of human breast tumors , 2012, Nature.

[10]  Andrew L. Kung,et al.  Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. , 2012, Cancer cell.

[11]  D. Bar-Sagi,et al.  RAS oncogenes: weaving a tumorigenic web , 2011, Nature Reviews Cancer.

[12]  C. Pfleger Ubiquitin on Ras: Warden or Partner in Crime? , 2011, Science Signaling.

[13]  K. Struhl,et al.  Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion , 2011, Proceedings of the National Academy of Sciences.

[14]  C. Paweletz,et al.  A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors , 2010, BMC Medical Genomics.

[15]  V. Trinkaus-Randall,et al.  RelB NF-κB Represses Estrogen Receptor α Expression via Induction of the Zinc Finger Protein Blimp1 , 2009, Molecular and Cellular Biology.

[16]  M. Nakao,et al.  HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. , 2009, The American journal of pathology.

[17]  Sean J. Morrison,et al.  Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression , 2008, Cell.

[18]  E. Gamelin,et al.  Improved proteome coverage by using iTRAQ labelling and peptide OFFGEL fractionation , 2008, Proteome Science.

[19]  A. Puisieux,et al.  Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition , 2008, PloS one.

[20]  Wenjun Guo,et al.  The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.

[21]  B. Park,et al.  Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation. , 2007, Cancer research.

[22]  P. Ekert,et al.  Programmed Anuclear Cell Death Delimits Platelet Life Span , 2007, Cell.

[23]  M. Diehn,et al.  Cancer stem cells and radiotherapy: new insights into tumor radioresistance. , 2006, Journal of the National Cancer Institute.

[24]  C. Thompson,et al.  PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. , 2006, Molecular cell.

[25]  M. Dean Cancer stem cells: Implications for cancer causation and therapy resistance. , 2005, Discovery medicine.

[26]  S. Lowe,et al.  Intrinsic tumour suppression , 2004, Nature.

[27]  F. Speleman,et al.  Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes , 2002, Genome Biology.

[28]  M. Pfaffl,et al.  A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.

[29]  T. Myers,et al.  An informatics approach identifying markers of chemosensitivity in human cancer cell lines. , 2000, Cancer research.

[30]  G. Evan,et al.  c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. , 1999, Genes & development.

[31]  Steven J. M. Jones,et al.  Comprehensive molecular portraits of human breast tumours , 2013 .

[32]  J. Downward Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.