Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
暂无分享,去创建一个
G. Getz | M. Meyerson | James R. Anderson | Jun S. Wei | L. Ambrogio | D. Auclair | J. Mora | S. Sindiri | J. Khan | S. Skapek | D. Hawkins | F. Barr | Thomas C. Badgett | A. Brohl | J. Chmielecki | Young K. Song | Jianjun Wang | R. Patidar | L. Hurd | Li Chen | J. Shern | Hongling Liao | Shile Zhang | D. Bogen | C. Tolman | D. Catchpoole | Mara W Rosenberg | Javed Khan | Sivasish Sindiri | Laura Hurd
[1] James R. Anderson,et al. PAX‐FOXO1 fusion status drives unfavorable outcome for children with rhabdomyosarcoma: A children's oncology group report , 2013, Pediatric blood & cancer.
[2] Khin Thway,et al. Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo , 2013, Clinical Cancer Research.
[3] C. Berking,et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. , 2013, The Lancet. Oncology.
[4] Steven J. M. Jones,et al. The genetic landscape of high-risk neuroblastoma , 2013, Nature Genetics.
[5] D. Hawkins,et al. Rhabdomyosarcoma: Review of the Children's Oncology Group (COG) soft‐tissue Sarcoma committee experience and rationale for current COG studies , 2012, Pediatric blood & cancer.
[6] Jill P. Mesirov,et al. MEDULLOBLASTOMA EXOME SEQUENCING UNCOVERS SUBTYPE-SPECIFIC SOMATIC MUTATIONS , 2012, Nature.
[7] Irmtraud M. Meyer,et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers , 2012, Nature.
[8] A. Sivachenko,et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer , 2012, Nature Genetics.
[9] Jessica C. Ebert,et al. Computational Techniques for Human Genome Resequencing Using Mated Gapped Reads , 2012, J. Comput. Biol..
[10] Kiran C. Bobba,et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia , 2012, Nature.
[11] Matthew W. Wilson,et al. A Novel Retinoblastoma Therapy from Genomic and Epigenetic Analyses , 2011, Nature.
[12] R. Arceci. PAX3/FOXO1 Fusion Gene Status Is the Key Prognostic Molecular Marker in Rhabdomyosarcoma and Significantly Improves Current Risk Stratification , 2012 .
[13] P. D. Rijk,et al. Optimized filtering reduces the error rate in detecting genomic variants by short-read sequencing , 2011, Nature Biotechnology.
[14] G. Grosveld,et al. PAX3-FOXO1 induces cannabinoid receptor 1 to enhance cell invasion and metastasis. , 2011, Cancer research.
[15] L. Borsu,et al. Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways , 2011, Clinical Cancer Research.
[16] L. Pasqualucci,et al. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. , 2011, Blood.
[17] S. Salzberg,et al. TopHat-Fusion: an algorithm for discovery of novel fusion transcripts , 2011, Genome Biology.
[18] Steven J. M. Jones,et al. Frequent mutation of histone modifying genes in non-Hodgkin lymphoma , 2011, Nature.
[19] A. McKenna,et al. The Mutational Landscape of Head and Neck Squamous Cell Carcinoma , 2011, Science.
[20] S. Cameron,et al. High‐resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis , 2011, Genes, chromosomes & cancer.
[21] S. Davis,et al. Exome sequencing identifies GRIN2A as frequently mutated in melanoma , 2011, Nature Genetics.
[22] Süleyman Cenk Sahinalp,et al. deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data , 2011, PLoS Comput. Biol..
[23] M. DePristo,et al. A framework for variation discovery and genotyping using next-generation DNA sequencing data , 2011, Nature Genetics.
[24] Trevor J Pugh,et al. Initial genome sequencing and analysis of multiple myeloma , 2011, Nature.
[25] Lynette M. Smith,et al. Genomic and Clinical Analysis of Amplification of the 13q31 Chromosomal Region in Alveolar Rhabdomyosarcoma: A Report from the Children's Oncology Group , 2011, Clinical Cancer Research.
[26] Lincoln Stein,et al. Reactome: a database of reactions, pathways and biological processes , 2010, Nucleic Acids Res..
[27] G. Grosveld,et al. PAX 3-FOXO 1 Induces Cannabinoid Receptor 1 to Enhance Cell Invasion and Metastasis , 2011 .
[28] P. Meltzer,et al. Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer. , 2011, Cancer research.
[29] J. Licht,et al. Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo , 2010, BMC Genomics.
[30] M. DePristo,et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. , 2010, Genome research.
[31] H. Hakonarson,et al. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.
[32] Cole Trapnell,et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. , 2010, Nature biotechnology.
[33] Robert B. Hartlage,et al. This PDF file includes: Materials and Methods , 2009 .
[34] W. Krzyzosiak,et al. Sequence-non-specific effects of RNA interference triggers and microRNA regulators , 2009, Nucleic acids research.
[35] R. Arceci. Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma , 2010 .
[36] S. Nelson,et al. BFAST: An Alignment Tool for Large Scale Genome Resequencing , 2009, PloS one.
[37] L. Staudt,et al. Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. , 2009, The Journal of clinical investigation.
[38] C. Dominici,et al. RAS signaling dysregulation in human embryonal Rhabdomyosarcoma , 2009, Genes, chromosomes & cancer.
[39] S. Ognjanovic,et al. Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975‐2005 , 2009, Cancer.
[40] Lynette M. Smith,et al. Genomic and clinical analyses of 2p24 and 12q13‐q14 amplification in alveolar rhabdomyosarcoma: A report from the Children's Oncology Group , 2009, Genes, chromosomes & cancer.
[41] Lior Pachter,et al. Sequence Analysis , 2020, Definitions.
[42] S. Henikoff,et al. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm , 2009, Nature Protocols.
[43] C. Linardic. PAX3-FOXO1 fusion gene in rhabdomyosarcoma. , 2008, Cancer letters.
[44] H. Xiang,et al. Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma , 2007, Modern Pathology.
[45] J. Herndon,et al. The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence. , 2007, Cancer research.
[46] Gabriel S. Eichler,et al. Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival. , 2007, Cancer research.
[47] J. A. Wamstad,et al. Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets , 2006, Molecular and Cellular Biology.
[48] Christian J Stoeckert,et al. STAC: A method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments. , 2006, Genome research.
[49] T. Triche,et al. Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas. , 2006, Cancer research.
[50] Y. Hayashi,et al. Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies , 2006, Genes, chromosomes & cancer.
[51] R. Arceci,et al. Gene Expression Signatures Identify Rhabdomyosarcoma Subtypes and Detect a Novel t(2;2)(q35;p23) Translocation Fusing PAX3 to NCOA1 , 2006 .
[52] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[53] Benjamin R. Arenkiel,et al. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. , 2004, Genes & development.
[54] 田中 佐. Research article , 2000, Hydrobiologia.
[55] James R. Anderson,et al. Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[56] G. Grosveld,et al. Pax3-FKHR Knock-In Mice Show Developmental Aberrations but Do Not Develop Tumors , 2002, Molecular and Cellular Biology.
[57] P. Sorensen,et al. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[58] P. Sorensen,et al. Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes , 2002, Genes, chromosomes & cancer.
[59] P. Houghton,et al. P53 mutation and MDM2 amplification frequency in pediatric rhabdomyosarcoma tumors and cell lines. , 2000, Medical and pediatric oncology.
[60] E. Verdin,et al. BCoR, a novel corepressor involved in BCL-6 repression. , 2000, Genes & development.
[61] M. Salgaller. American Association for Cancer Research , 2000, Expert opinion on investigational drugs.
[62] M. Bittner,et al. Elucidation of the Downstream Targets of the PAX3-FKHR Fusion Oncogene Found in Aveolar Rhabdomyosarcoma Using cDNA Microarrays , 1999 .
[63] M. Bittner,et al. Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays. , 1998, Cancer research.
[64] G. Basso,et al. Analysis of cyclin‐dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in childhood rhabdomyosarcoma , 1996, Genes, chromosomes & cancer.
[65] Y. Benjamini,et al. Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .
[66] J. Biegel,et al. Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. , 1994, Cancer research.
[67] E. Gehan,et al. The intergroup rhabdomyosarcoma study‐II , 1993, Cancer.
[68] J. Biegel,et al. Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma , 1993, Nature Genetics.
[69] M. Stratton,et al. Detection of point mutations in N-ras and K-ras genes of human embryonal rhabdomyosarcomas using oligonucleotide probes and the polymerase chain reaction. , 1989, Cancer research.
[70] C. Sapienza,et al. A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting , 1989 .
[71] E. Gehan,et al. The intergroup rhabdomyosarcoma study‐I. A final report , 1988, Cancer.