In vitro assessments of antibacterial potential of Commiphora wightii (Arn.) Bhandari. gum extract

The potential antibacterial efficacy of guggul gum was checked against six Gram-positive and four Gram-negative bacterial strains. The antibacterial activity was assessed by agar well diffusion and two fold serial broth dilution methods. Gram-positive bacterial strains were found to be the most susceptible organisms compare to Gram-negative towards guggul gum extract once. The minimum inhibitory concentration (MIC) noticed in concentration range of 0.5 - 2 mg/ml. The bioautography was performed to localize active compound present in crude as well as eluted fraction. Compound 5(1methyl, 1-amino ethyl)-5- methyl-2-octanone, identified which possessed antibacterial activity by various spectrometric method. The extract of guggul gum possesses significant antibacterial activity against Staphylococcus aureus.

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