论文信息 - Noradrenaline release from isolated nerve granules.

Noradrenaline release from isolated nerve granules.

Euler U. S. V. and F. Lishajko. Noradrenaline release from isolated nerve granules. Some properties of isolated transmitter granules obtained by high g centrifugation of press juice from bovine splenic nerves have been studied. Of the total noradrenaline present in the press juice 20–35 per cent was recovered in the sediment. The granules are stable for several hours at + 4° C but rapidly lose their noradrenaline on incubation in isotonic neutral media at 37° C. Noradrenaline is rapidly released even at low temperature at pH 4 and below, and by detergents. Hypo- and hyperosmotic solutions and freezing and thawing, had a moderate releasing effect. Acetylcholine, nicotine, serotonin and GABA had no detectable effect on the noradrenaline release from the granules. Nerve granules are more sensitive to temperature than adrenal medullary granules but show higher resistance to freezing and thawing and osmotic changes.

U. V. von Euler | F. Lishajko

[1] U. V. von Euler,et al. Effect of Reserpine on Release of Noradrenaline from Transmitter Granules in Adrenergic Nerves , 1960, Science.

[2] U. V. von Euler,et al. The estimation of catechol amines in urine. , 1959, Acta physiologica Scandinavica.

[3] U. S. Euler. The Presence of the Adrenergic Nenrotransmitter in Intraaxonal Structures. , 1958 .

[4] B. Falck,et al. Content and intracellular distribution of adenosine triphosphate in cow adrenal medulla. , 1956, Acta physiologica Scandinavica.

[5] U. S. Euler,et al. Evidence for the Presence of Noradrenaline in Submicroscopic Structures of Adrenergic Axons , 1956, Nature.

[6] N. Hillarp,et al. The structure of the adrenaline and noradrenaline containing granules in the adrenal medullary cells with reference to the storage and release of the sympathomimetic amines. , 1954, Acta physiologica Scandinavica. Supplementum.