Heart rate acceleration and its relationship to total serum cholesterol, triglycerides, and blood pressure reactivity in men with mild hypertension.

This study investigated heart rate (HR) acceleration and its relationship to serum cholesterol, triglycerides, and blood pressure reactivity in a group of men with unmedicated mild hypertension. Each man's cardiovascular responses were monitored as he performed the Stroop Color Word Interference test and played the Pac Man Videogame. In comparison to their low HR accelerator counterparts, high HR accelerators manifested greater systolic and diastolic blood pressure responses during behavioral challenge. Moreover, high HR accelerators exhibited higher levels of serum cholesterol and triglycerides than low HR accelerators, even though these determinations were made from blood drawn during the clinic visit that preceded the clinic visit where cardiovascular reactivity was assessed. Heart rate acceleration and its positive association with serum lipids, as well as its role as a potential individual difference relevant to the profiling of persons at greater risk for the development of atherosclerosis were discussed.

[1]  M. Trevisan,et al.  Short‐Term Effect of Natural Disasters on Coronary Heart Disease Risk Factors , 1986, Arteriosclerosis.

[2]  W. Castelli,et al.  Epidemiology of coronary heart disease: the Framingham study. , 1984, The American journal of medicine.

[3]  A. Steptoe,et al.  Behavioral Response Demands, Cardiovascular Reactivity, and Essential Hypertension , 1984, Psychosomatic medicine.

[4]  J. Dimsdale,et al.  Epinephrine Mediated Increases in Plasma Cholesterol , 1983, Psychosomatic medicine.

[5]  S. Grundy Atherosclerosis: pathology, pathogenesis, and role of risk factors. , 1983, Disease-a-month : DM.

[6]  S. Manuck,et al.  Behaviorally Induced Heart Rate Reactivity and Atherosclerosis in Cynomolgus Monkeys , 1983, Psychosomatic medicine.

[7]  D. Berger,et al.  The Effects of Differential Psychological Stress on Plasma Cholesterol Levels in Rats , 1980, Psychosomatic medicine.

[8]  P. Obrist,et al.  The relationship among heart rate, caratid dP/dt, and blood pressure in humans as a function of the type of stress. , 1978, Psychophysiology.

[9]  P. Taggart,et al.  Electrocardiogram, plasma catecholamines and lipids, and their modification by oxyprenolol when speaking before an audience. , 1973, Lancet.

[10]  K. E. Isom,et al.  Cholesterol synthesis and metabolism as a function of unpredictable shock stimulation. , 1973, Physiology & behavior.

[11]  P. Taggart,et al.  Suppression by oxprenolol of adrenergic response to stress. , 1972, Lancet.

[12]  D. Steinberg,et al.  The nature of the epinephrine-induced hyperlipidemia in dogs and its modification by glucose. , 1959 .

[13]  R. Havel,et al.  The role of the sympathetic nervous system in the metabolism of free fatty acids , 1959 .

[14]  M. Allen,et al.  Evaluation of beta-adrenergic influences on cardiovascular and metabolic adjustments to physical and psychological stress. , 1986, Psychophysiology.

[15]  G. Eisenhofer,et al.  Beta-adrenoceptor responsiveness and plasma catecholamines as determinants of cardiovascular reactivity to mental stress. , 1985, Clinical science.

[16]  P. Obrist,et al.  Cardiopulmonary adjustments during exercise and an aversive reaction time task: effects of beta-adrenoceptor blockade. , 1985, Psychophysiology.

[17]  P. Obrist,et al.  Sympathetic neuronal function and left ventricular performance during behavioral stress in humans: the relationship between plasma catecholamines and systolic time intervals. , 1983, Psychophysiology.

[18]  J. Henry,et al.  Stress, Health, and the Social Environment , 1977, Topics in Environmental Physiology and Medicine.