Bone marrow fat quantification in the presence of trabecular bone: Initial comparison between water‐fat imaging and single‐voxel MRS

The purpose of the present study was to test the relative performance of chemical shift‐based water‐fat imaging in measuring bone marrow fat fraction in the presence of trabecular bone, having as reference standard the single‐voxel magnetic resonance spectroscopy (MRS).

[1]  J. Woo,et al.  Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation. , 2006, Radiology.

[2]  K. Nayak,et al.  Comparison of Fat–Water MRI and Single‐voxel MRS in the Assessment of Hepatic and Pancreatic Fat Fractions in Humans , 2010, Obesity.

[3]  J. Woo,et al.  Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study , 2005, Journal of magnetic resonance imaging : JMRI.

[4]  M. Skalej,et al.  Volume‐selective proton MRS in vertebral bodies , 1992, Magnetic resonance in medicine.

[5]  C. Sirlin,et al.  Relaxation effects in the quantification of fat using gradient echo imaging. , 2008, Magnetic resonance imaging.

[6]  S. Reeder,et al.  Multiecho reconstruction for simultaneous water‐fat decomposition and T2* estimation , 2007, Journal of magnetic resonance imaging : JMRI.

[7]  S. Majumdar,et al.  T1‐corrected fat quantification using chemical shift‐based water/fat separation: Application to skeletal muscle , 2011, Magnetic resonance in medicine.

[8]  Scott B Reeder,et al.  Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy. , 2011, Radiology.

[9]  Xiaojuan Li,et al.  Quantification of vertebral bone marrow fat content using 3 tesla MR spectroscopy: Reproducibility, vertebral variation, and applications in osteoporosis , 2011, Journal of magnetic resonance imaging : JMRI.

[10]  S. Reeder,et al.  Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy , 2011, Journal of magnetic resonance imaging : JMRI.

[11]  S. Reeder,et al.  Quantification of hepatic steatosis with MRI: The effects of accurate fat spectral modeling , 2009, Journal of magnetic resonance imaging : JMRI.

[12]  S. Reeder,et al.  Comparison of R2* correction methods for accurate fat quantification in fatty liver , 2013, Journal of magnetic resonance imaging : JMRI.

[13]  C. Sirlin,et al.  In vivo characterization of the liver fat 1H MR spectrum , 2011, NMR in biomedicine.

[14]  Sharmila Majumdar,et al.  Chemical shift‐based water/fat separation in the presence of susceptibility‐induced fat resonance shift , 2012, Magnetic resonance in medicine.

[15]  G. Gold,et al.  Iterative decomposition of water and fat with echo asymmetry and least‐squares estimation (IDEAL): Application with fast spin‐echo imaging , 2005, Magnetic resonance in medicine.

[16]  S. Reeder,et al.  Multiecho water‐fat separation and simultaneous R  2* estimation with multifrequency fat spectrum modeling , 2008, Magnetic resonance in medicine.

[17]  S. Reeder,et al.  Addressing phase errors in fat‐water imaging using a mixed magnitude/complex fitting method , 2012, Magnetic resonance in medicine.

[18]  Krishna S Nayak,et al.  Quantification of Absolute Fat Mass by Magnetic Resonance Imaging: a Validation Study against Chemical Analysis. , 2011, International journal of body composition research.

[19]  K. Vigen,et al.  T1 independent, T2* corrected chemical shift based fat–water separation with multi‐peak fat spectral modeling is an accurate and precise measure of hepatic steatosis , 2011, Journal of magnetic resonance imaging : JMRI.

[20]  Ping Chung Leung,et al.  Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy. , 2005, Radiology.

[21]  S. Reeder,et al.  Combination of complex‐based and magnitude‐based multiecho water‐fat separation for accurate quantification of fat‐fraction , 2011, Magnetic resonance in medicine.

[22]  Michael Markl,et al.  Multicoil Dixon chemical species separation with an iterative least‐squares estimation method , 2004, Magnetic resonance in medicine.

[23]  R. Milner,et al.  MRI Measurement of Bone Marrow Cellularity for Radiation Dosimetry , 2011, The Journal of Nuclear Medicine.

[24]  Jeffry S Nyman,et al.  Characterization of 1H NMR signal in human cortical bone for magnetic resonance imaging , 2010, Magnetic resonance in medicine.

[25]  S. Reeder,et al.  Proton density fat‐fraction: A standardized mr‐based biomarker of tissue fat concentration , 2012, Journal of magnetic resonance imaging : JMRI.

[26]  Xiaojuan Li,et al.  Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? , 2012, Journal of magnetic resonance imaging : JMRI.

[27]  S. Horgan,et al.  Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T. , 2011, Radiology.

[28]  Huanzhou Yu,et al.  On the performance of T2* correction methods for quantification of hepatic fat content , 2012, Magnetic resonance in medicine.

[29]  P Kellman,et al.  Joint estimation of water/fat images and field inhomogeneity map , 2008, Magnetic resonance in medicine.

[30]  S. B. Reeder,et al.  Relationship between Proton-Density Fat-Fraction and True Fat Concentration for In Vivo Fat Quantification with Magnetic Resonance Imaging , 2010 .

[31]  S. Reeder,et al.  Fat quantification with IDEAL gradient echo imaging: Correction of bias from T1 and noise , 2007, Magnetic resonance in medicine.

[32]  M. Skalej,et al.  Proton relaxation times in human red bone marrow by volume selective magnetic resonance spectroscopy , 1992 .