Toward Safer Treatment Options for Advanced Keratoconus

Keratoconus is a bilateral and progressive corneal disease characterized by a significant increase in irregular astigmatism and corneal thinning. Numerous treatments—including penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), ultraviolet-crosslinking (UV-CXL), and intracorneal ring segments—are available for halting progression and/or obtaining (partial) visual rehabilitation. Recently, midstromal Bowman layer transplantation has been introduced as a new treatment option for advanced keratoconus. This technique has shown significant promise in halting disease progression and postponing riskier procedures such as PK or DALK.

[1]  R. Wisse,et al.  Does lamellar surgery for keratoconus experience the popularity it deserves? , 2014, Acta ophthalmologica.

[2]  E. G. Groeneveld-van Beek,et al.  Midstromal isolated Bowman layer graft for reduction of advanced keratoconus: a technique to postpone penetrating or deep anterior lamellar keratoplasty. , 2014, JAMA ophthalmology.

[3]  G. Snibson,et al.  Current status of corneal collagen cross‐linking for keratoconus: a review , 2013, Clinical & experimental optometry.

[4]  C. Rapuano,et al.  The Role of Penetrating Keratoplasty in the Era of Selective Lamellar Keratoplasty , 2013, International ophthalmology clinics.

[5]  S. Dorairaj,et al.  Early outcomes of primary pediatric keratoplasty in patients with acquired, atraumatic corneal pathology. , 2011, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus.

[6]  D. Coster,et al.  Repeat penetrating corneal transplantation in patients with keratoconus. , 2011, Ophthalmology.

[7]  L. el Matri,et al.  Pediatric penetrating keratoplasty: indications and outcomes. , 2011, Transplantation proceedings.

[8]  J. Alió,et al.  Intracorneal ring segments in ectatic corneal disease – a review , 2010, Clinical & experimental ophthalmology.

[9]  M. Banitt,et al.  Recurrent ectasia in corneal grafts and outcomes of repeat keratoplasty for keratoconus , 2008, British Journal of Ophthalmology.

[10]  G. Mitchell,et al.  Personality in Keratoconus in a Sample of Patients Derived From the Internet , 2005, Cornea.

[11]  E. Cohen,et al.  Cataract Extraction Following Penetrating Keratoplasty , 2004, Cornea.

[12]  J. Grigg,et al.  Penetrating keratoplasty in children: visual and graft outcome , 2003, The British journal of ophthalmology.

[13]  W H Beekhuis,et al.  Suture-related Complications Following Keratoplasty: A 5-Year Retrospective Study , 2001, Cornea.

[14]  H. Völker‐Dieben,et al.  Patient Satisfaction After Corneal Transplantation , 2001, Cornea.

[15]  R. Olson,et al.  Penetrating keratoplasty for keratoconus: a long-term review of results and complications. , 2000, Journal of cataract and refractive surgery.

[16]  C. Legault,et al.  Cataract formation and cataract extraction after penetrating keratoplasty. , 1994, Ophthalmology.

[17]  D. Coster,et al.  Long-term outcome after corneal transplantation. Visual result and patient perception of success. , 1991, Ophthalmology.

[18]  J. F. Cullen,et al.  MONGOLISM (DOWN'S SYNDROME) AND KERATOCONUS*† , 1963, The British journal of ophthalmology.