Use of liposomes, emulsions, or inclusion complexes may potentiate in-vivo effects of SnET2

The majority of second generation sensitizers being proposed as possible alternatives to hematoporphyrin derivative, in photodynamic therapy, are hydrophobic in nature. Consequently, specific carrier systems have to be developed for in vivo administration. As an attempt to understand the interactions of these delivery systems in vivo, plasma binding properties of the sensitizer SnET2 complexed with liposomes, emulsions or cyclodextrins have been studied. Additional studies have investigated the effect of the carrier system on the cytotoxicity of SnET2 on transplantable tumors. Preliminary data suggest that tumor response may be mediated by the choice of carrier system. Further studies appear to be necessary before the optimum thug/carrier system complex can be defined.

[1]  E. Reddi,et al.  Preferential delivery of liposome-incorporated porphyrins to neoplastic cells in tumour-bearing rats. , 1983, British Journal of Cancer.

[2]  G. Jori,et al.  In vivo transport and pharmacokinetic behavior of tumour photosensitizers. , 1989, Ciba Foundation symposium.

[3]  R. Keck,et al.  New photosensitizers for photodynamic therapy: combined effect of metallopurpurin derivatives and light on transplantable bladder tumors. , 1988, Cancer research.

[4]  L. Huang,et al.  Preparation and characterization of heat-sensitive immunoliposomes. , 1985, Biochimica et biophysica acta.

[5]  Giulio Jori,et al.  DISTRIBUTION OF PORPHYRINS IN THE VARIOUS COMPARTMENTS OF UNILAMELLAR LIPOSOMES OF DIPALMITOYL‐PHOSPHATIDYLCHOLINE AS PROBED BY FLUORESCENCE SPECTROSCOPY , 1986, Photochemistry and photobiology.

[6]  R. Anderson,et al.  TRANSMITTANCE OF NONIONIZING RADIATION IN HUMAN TISSUES * , 1981, Photochemistry and photobiology.

[7]  R J Havel,et al.  Introduction to the plasma lipoproteins. , 1986, Methods in enzymology.

[8]  T J Dougherty,et al.  PHOTOSENSITIZERS: THERAPY AND DETECTION OF MALIGNANT TUMORS , 1987, Photochemistry and photobiology.

[9]  F. Sánchez-Muniz,et al.  Improved techniques for the separation of serum lipoproteins by density gradient ultracentrifugation: visualization by prestaining and rapid separation of serum lipoproteins from small volumes of serum. , 1981, Analytical biochemistry.

[10]  E. Reddi,et al.  ULTRASTRUCTURAL STUDIES ON THE MECHANISM OF THE PHOTODYNAMIC THERAPY OF TUMORS , 1987, Photochemistry and photobiology.

[11]  R. Keck,et al.  A dose response analysis of purpurin derivatives used as photosensitizers for the photodynamic treatment of transplantable FANFT induced urothelial tumors. , 1987, The Journal of urology.

[12]  C. E. West,et al.  Separation of plasma lipoproteins by density-gradient ultracentrifugation. , 1975, Analytical biochemistry.

[13]  R. Mahley,et al.  Canine Lipoproteins and Atherosclerosis: I. Isolation and Characterization of Plasma Lipoproteins from Control Dogs , 1974, Circulation research.