Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress
暂无分享,去创建一个
Z. Gong | D. Stainier | Kimberly J Morgan | R. Molania | A. Papenfuss | L. Whitehead | C. Simons | Karen Doggett | G. Baillie | E. Ober | J. Heath | T. Hall | Kelly A. Smith | B. Hogan | Fansuo Geng | Elke A. Ober | Cas Simons
[1] A. Pandiella,et al. Proteolysis targeting chimeras (PROTACs) in cancer therapy , 2020, Journal of Experimental & Clinical Cancer Research.
[2] Jenifer B. Kaplan,et al. PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions. , 2020, ACS chemical biology.
[3] P. Currie,et al. Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A , 2019, npj Regenerative Medicine.
[4] Shawn C. Little,et al. Chromatin targeting of nuclear pore proteins induces chromatin decondensation , 2019, The Journal of cell biology.
[5] Aviad Tsherniak,et al. Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines , 2019, bioRxiv.
[6] D. Jans,et al. Inhibitors of nuclear transport. , 2019, Current opinion in cell biology.
[7] H. Kurumizaka,et al. Structural and biochemical analyses of the nuclear pore complex component ELYS identify residues responsible for nucleosome binding , 2019, Communications Biology.
[8] Z. Gong,et al. Transcriptomic analyses of oncogenic hepatocytes reveal common and different molecular pathways of hepatocarcinogenesis in different developmental stages and genders in krasG12V transgenic zebrafish. , 2019, Biochemical and biophysical research communications.
[9] S. Lowe,et al. Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import , 2018, Cell.
[10] L. Lai,et al. Synthetic lethality in drug development: the dawn is coming. , 2018, Future medicinal chemistry.
[11] P. Schirmacher,et al. Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies. , 2017, Journal of hepatology.
[12] Ann E. Sizemore,et al. Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells , 2017, Nature Genetics.
[13] Alan Ashworth,et al. PARP inhibitors: Synthetic lethality in the clinic , 2017, Science.
[14] Eric S. Lander,et al. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras , 2017, Cell.
[15] M. Beck,et al. The nuclear pore complex: understanding its function through structural insight , 2016, Nature Reviews Molecular Cell Biology.
[16] R. Bernards,et al. A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility , 2016, Cell.
[17] J. Zucman‐Rossi,et al. Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. , 2015, Gastroenterology.
[18] S. Gery,et al. KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma , 2014, Cancer Chemotherapy and Pharmacology.
[19] B. C. Low,et al. Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models , 2014, Oncogene.
[20] Weiling Zheng,et al. Xmrk, Kras and Myc Transgenic Zebrafish Liver Cancer Models Share Molecular Signatures with Subsets of Human Hepatocellular Carcinoma , 2014, PloS one.
[21] S. Grimmond,et al. Minor class splicing shapes the zebrafish transcriptome during development , 2014, Proceedings of the National Academy of Sciences.
[22] Juan Carlos González-Sánchez,et al. The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation , 2014, Nature Communications.
[23] R. Hill,et al. Targeting nucleocytoplasmic transport in cancer therapy , 2013, Oncotarget.
[24] C. Hashizume,et al. Down-modulation of nucleoporin RanBP2/Nup358 impaired chromosomal alignment and induced mitotic catastrophe , 2013, Cell Death and Disease.
[25] John R. Yates,et al. Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures , 2013, Cell.
[26] Benjamin E. Gross,et al. Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal , 2013, Science Signaling.
[27] T. Schwartz,et al. Structural and functional studies of the 252 kDa nucleoporin ELYS reveal distinct roles for its three tethered domains. , 2013, Structure.
[28] Seok-Hyung Kim,et al. Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis , 2013, PLoS genetics.
[29] A. Strasser,et al. DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa. , 2012, Molecular cell.
[30] T. Schwartz,et al. Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex , 2012, Proceedings of the National Academy of Sciences.
[31] B. Paw,et al. Mutation mapping and identification by whole-genome sequencing , 2012, Genome research.
[32] Benjamin E. Gross,et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. , 2012, Cancer discovery.
[33] W. Driever,et al. Fast Homozygosity Mapping and Identification of a Zebrafish ENU-Induced Mutation by Whole-Genome Sequencing , 2012, PloS one.
[34] B. Fahrenkrog,et al. Nucleoporins: leaving the nuclear pore complex for a successful mitosis. , 2011, Cellular signalling.
[35] G Melino,et al. p63 and p73, the ancestors of p53. , 2010, Cold Spring Harbor perspectives in biology.
[36] B. Fontoura,et al. The Nup107-160 complex and γ-TuRC regulate microtubule polymerization at kinetochores , 2010, Nature Cell Biology.
[37] Michael J. Emanuele,et al. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene , 2009, Cell.
[38] L. Zon,et al. Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish. , 2009, Gastroenterology.
[39] U. Kutay,et al. Orchestrating nuclear envelope disassembly and reassembly during mitosis , 2009, Nature Reviews Molecular Cell Biology.
[40] A. Moorman,et al. Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data , 2009, Nucleic acids research.
[41] M. D'Angelo,et al. Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells , 2009, Cell.
[42] M. Pack,et al. Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress , 2008, PLoS genetics.
[43] Thorsten Wohland,et al. Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish , 2008, BMC Developmental Biology.
[44] A. Harel,et al. Capture of AT-rich chromatin by ELYS recruits POM121 and NDC1 to initiate nuclear pore assembly. , 2008, Molecular biology of the cell.
[45] J. Swedlow,et al. ELYS/MEL-28 Chromatin Association Coordinates Nuclear Pore Complex Assembly and Replication Licensing , 2007, Current Biology.
[46] S. Elledge,et al. Non-Oncogene Addiction and the Stress Phenotype of Cancer Cells , 2007, Cell.
[47] M. Hetzer,et al. MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly , 2007, EMBO reports.
[48] S. Briggs,et al. ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division , 2006, Proceedings of the National Academy of Sciences.
[49] A. Yang,et al. p63 protects the female germ line during meiotic arrest , 2006, Nature.
[50] Samantha G. Zeitlin,et al. The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly. , 2006, Molecular biology of the cell.
[51] D. Stainier,et al. Mesodermal Wnt2b signalling positively regulates liver specification , 2006, Nature.
[52] S. Thorgeirsson,et al. Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. , 2006, Gastroenterology.
[53] L. Zon,et al. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[54] H. Kiyonari,et al. Targeted disruption of the mouse ELYS gene results in embryonic death at peri‐implantation development , 2004, Genes to cells : devoted to molecular & cellular mechanisms.
[55] M. Dasso,et al. The RanGAP1-RanBP2 Complex Is Essential for Microtubule-Kinetochore Interactions In Vivo , 2004, Current Biology.
[56] Pamela A. Silver,et al. Nuclear transport and cancer: from mechanism to intervention , 2004, Nature Reviews Cancer.
[57] J. B. Rattner,et al. Nup358 integrates nuclear envelope breakdown with kinetochore assembly , 2003, The Journal of cell biology.
[58] G Melino,et al. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. , 2000, Journal of cell science.
[59] C. Nüsslein-Volhard,et al. Mutations affecting the cardiovascular system and other internal organs in zebrafish. , 1996, Development.
[60] C. Nüsslein-Volhard,et al. Mutations affecting pigmentation and shape of the adult zebrafish , 1996, Development Genes and Evolution.