Use of paracetamol in ischaemic stroke patients: evidence from VISTA

Paracetamol is frequently prescribed for pain and fever control in acute stroke patients, but its effect on stroke outcome is unclear. The aim was to investigate the safety and benefit of paracetamol administration in the acute phase of ischaemic stroke.

[1]  B. Rosner,et al.  An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987) , 1991, The New England journal of medicine.

[2]  U. Dirnagl,et al.  Central nervous system injury-induced immune deficiency syndrome , 2005, Nature Reviews Neuroscience.

[3]  J. Manson,et al.  Nonsteroidal Antiinflammatory Drugs, Acetaminophen, and the Risk of Cardiovascular Events , 2006, Circulation.

[4]  Adnan I. Qureshi,et al.  Guidelines for the Early Management of Adults With Ischemic Stroke , 2007 .

[5]  J. Grotta,et al.  The Virtual International Stroke Trials Archive , 2007, Stroke.

[6]  Gary A. Ford,et al.  Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. , 2008, Cerebrovascular diseases.

[7]  Christian Weimar,et al.  Predicting Long-Term Outcome After Acute Ischemic Stroke: A Simple Index Works in Patients From Controlled Clinical Trials , 2008, Stroke.

[8]  A. Algra,et al.  The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial , 2009, The Lancet Neurology.

[9]  J. Grotta,et al.  Thrombolysis Is Associated With Consistent Functional Improvement Across Baseline Stroke Severity: A Comparison of Outcomes in Patients From the Virtual International Stroke Trials Archive (VISTA) , 2010, Stroke.

[10]  G. Merrill,et al.  Acetaminophen reduces mitochondrial dysfunction during early cerebral postischemic reperfusion in rats , 2010, Brain Research.

[11]  H. D. den Hertog,et al.  Effects of high‐dose paracetamol on blood pressure in acute stroke , 2012, Acta neurologica Scandinavica.