Confirmation of fenfluramine effect on 5-HT1B binding of [11C]AZ10419369 using an equilibrium approach

Introduction: We previously reported an initial PET-study evaluating the effect of (±)-fenfluramine-induced serotonin release on the binding of the selective serotonin 5-HT1B receptor radioligand [C]AZ10419369 in cynomolgus monkeys (1). In a classical displacement paradigm after bolus administration of radioligand fenfluramine caused a dose-dependent reduction in specific binding ratios. The aim of this study was to confirm our previous findings by using a bolus plus continuous infusion approach in monkey.