Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomnia.
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Joe A. Tran | G. Beaton | Jinghua Yu | S. Malany | P. Crowe | Samuel R J Hoare | A. Madan | M. Arellano | F. Tucci | W. J. Moree | Binfeng Li | Jianyun Wen | S. Ravula | R. Petroski | Satheesh B Ravula