A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway.

[1]  Yahui Kong,et al.  CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets , 2018, Diabetes.

[2]  S. Wakana,et al.  The parathyroid hormone regulates skin tumour susceptibility in mice , 2017, Scientific Reports.

[3]  J. Long,et al.  The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer , 2016, PLoS genetics.

[4]  S. Wakana,et al.  Identification of Stmm3 locus Conferring Resistance to Late-stage Chemically Induced Skin Papillomas on Mouse Chromosome 4 by Congenic Mappingand Allele-specific Alteration Analysis , 2014, Experimental animals.

[5]  J. Weber,et al.  ARF tumor suppression in the nucleolus. , 2014, Biochimica et biophysica acta.

[6]  S. Wakana,et al.  Congenic Mapping and Allele-Specific Alteration Analysis of Stmm1 Locus Conferring Resistance to Early-Stage Chemically Induced Skin Papillomas , 2014, PloS one.

[7]  Marie M. Lee,et al.  Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans , 2014, Proceedings of the National Academy of Sciences.

[8]  I. Ben-Porath,et al.  Dynamics of senescent cell formation and retention revealed by p14ARF induction in the epidermis. , 2013, Cancer research.

[9]  Raffaele A. Calogero,et al.  Mimicking p14ARF Phosphorylation Influences Its Ability to Restrain Cell Proliferation , 2013, PloS one.

[10]  S. Wakana,et al.  Independent genetic control of early and late stages of chemically induced skin tumors in a cross of a Japanese wild-derived inbred mouse strain, MSM/Ms. , 2012, Carcinogenesis.

[11]  J. Mao,et al.  Cancer evolution and individual susceptibility. , 2011, Integrative biology : quantitative biosciences from nano to macro.

[12]  R. Brakenhoff,et al.  Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways , 2011, International journal of cancer.

[13]  Q. Wei,et al.  p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck , 2011, Cancer.

[14]  Y. Ishikawa,et al.  Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. , 2010, Cancer research.

[15]  Kenneth Offit,et al.  Genome-wide association studies of cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  R. Elliott,et al.  New outbred colony derived from Mus musculus castaneus to identify skin tumor susceptibility loci , 2010, Molecular carcinogenesis.

[17]  Judy H. Cho,et al.  Finding the missing heritability of complex diseases , 2009, Nature.

[18]  K. Kiguchi,et al.  Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications , 2009, Nature Protocols.

[19]  B. Ponder,et al.  Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. , 2008, Carcinogenesis.

[20]  M. Kimura,et al.  New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK , 2007, BMC Genetics.

[21]  A. Balmain,et al.  Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice , 2007, Nature.

[22]  A. Balmain,et al.  A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice , 2006, Nature Genetics.

[23]  T. Shiraishi,et al.  PKCα is involved in phorbol ester TPA-mediated stabilization of p14ARF , 2005 .

[24]  Y. Yasui,et al.  p19 Arf Suppresses Growth, Progression, and Metastasis of Hras-Driven Carcinomas through p53-Dependent and -Independent Pathways , 2004, PLoS biology.

[25]  Hiroki Nagase,et al.  Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human , 2003, Nature Genetics.

[26]  J. DiGiovanni,et al.  Identification of novel genetic loci contributing to 12-O-tetradecanoylphorbol-13-acetate skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice. , 2003, Cancer research.

[27]  E. Salido,et al.  A new locus for resistance to γ-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice , 2002, Oncogene.

[28]  R. DePinho,et al.  A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression , 2002, Oncogene.

[29]  M. Chazal,et al.  P16INK4A is implicated in both the immediate and adaptative response of human keratinocytes to UVB irradiation , 2002, Oncogene.

[30]  R. DePinho,et al.  Efficiency Alleles of the Pctr1 Modifier Locus for Plasmacytoma Susceptibility , 2001, Molecular and Cellular Biology.

[31]  N. Zanesi,et al.  Linkage disequilibrium and haplotype mapping of a skin cancer susceptibility locus in outbred mice , 2000, Mammalian Genome.

[32]  T. Taniguchi,et al.  Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. , 2000, Science.

[33]  M. Serrano,et al.  The INK4a/ARF locus in murine tumorigenesis. , 2000, Carcinogenesis.

[34]  D. Beach,et al.  p16INK4A and p19ARF act in overlapping pathways in cellular immortalization , 2000, Nature Cell Biology.

[35]  A. Balmain,et al.  A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[36]  F. Zindy,et al.  Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[37]  E. Ramsay,et al.  Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Richard A. Ashmun,et al.  Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF , 1997, Cell.

[39]  K. Minda,et al.  Association of a murine chromosome 9 locus (Psl1) with susceptibility to mouse skin tumor promotion by 12‐O‐tetradecanoylphorbol‐13‐acetate , 1997, Molecular carcinogenesis.

[40]  D. Quelle,et al.  Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[41]  A. Balmain,et al.  Distinct genetic loci control development of benign and malignant skin tumours in mice , 1995, Nature Genetics.

[42]  John Calvin Reed,et al.  Tumor suppressor p53 is a direct transcriptional activator of the human bax gene , 1995, Cell.

[43]  N. Hay,et al.  Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. , 1994, Genes & development.

[44]  G. T. Bowden,et al.  Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[45]  V. Rotter,et al.  Nuclear localization is essential for the activity of p53 protein. , 1991, Oncogene.

[46]  David P. Lane,et al.  Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport , 1991, Nature.

[47]  G. Doria,et al.  Genetics of chemical carcinogenesis. 1. Bidirectional selective breeding of susceptible and resistant lines of mice to two-stage skin carcinogenesis. , 1990, Carcinogenesis.

[48]  Q. Wei,et al.  Potentially functional variants of p14ARF are associated with HPV-positive oropharyngeal cancer patients and survival after definitive chemoradiotherapy. , 2014, Carcinogenesis.

[49]  A. Yoshiki,et al.  Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain , 2008, Mammalian Genome.

[50]  C. Lopes,et al.  Chemical carcinogenesis. , 2007, Anais da Academia Brasileira de Ciencias.

[51]  A. Balmain,et al.  Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[52]  L. Ashman,et al.  Two-stage skin carcinogenesis in sensitive and resistant mouse strains. , 1982, Carcinogenesis.