The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
暂无分享,去创建一个
John M. Cunningham | J. Cunningham | H. Raghuraman | Donald Wolfgeher | N. Sundaresan | S. Samant | V. Pillai | Madhu Gupta | Nagalingam R. Sundaresan | Vinodkumar B. Pillai | Don Wolfgeher | Sadhana Samant | Prabhakaran Vasudevan | Vishwas Parekh | Hariharasundaram Raghuraman | Madhu Gupta | Mahesh P. Gupta | Vishwas Parekh | P. Vasudevan | M. Gupta | Donald J Wolfgeher
[1] S. Lamberts,et al. IGF-I and Longevity , 2004, Hormone Research in Paediatrics.
[2] Lewis C Cantley,et al. PI3K: Downstream AKTion Blocks Apoptosis , 1997, Cell.
[3] Lewis C. Cantley,et al. AKT/PKB Signaling: Navigating Downstream , 2007, Cell.
[4] M. Mann,et al. Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions , 2009, Science.
[5] Delin Chen,et al. Mammalian SIRT1 Represses Forkhead Transcription Factors , 2004, Cell.
[6] R. Roth,et al. Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation* , 1996, The Journal of Biological Chemistry.
[7] Phillip T. Hawkins,et al. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B , 1998, Current Biology.
[8] David Sinclair,et al. Sirtuins in mammals: insights into their biological function. , 2007, The Biochemical journal.
[9] P. Cohen,et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα , 1997, Current Biology.
[10] Brian C. Smith,et al. Mechanism of Human SIRT1 Activation by Resveratrol* , 2005, Journal of Biological Chemistry.
[11] N. Sundaresan,et al. Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway* , 2009, The Journal of Biological Chemistry.
[12] D. Guertin,et al. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.
[13] F. McCormick,et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. , 1997, Science.
[14] C. Deng. SIRT1, Is It a Tumor Promoter or Tumor Suppressor? , 2009, International journal of biological sciences.
[15] I. Komuro,et al. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway , 2004, The EMBO journal.
[16] J. Ross,et al. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[17] C. Kahn,et al. Akt Signaling Mediates Postnatal Heart Growth in Response to Insulin and Nutritional Status* , 2002, The Journal of Biological Chemistry.
[18] N. Sundaresan,et al. SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70 , 2008, Molecular and Cellular Biology.
[19] Irving L Weissman,et al. SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. , 2007, Molecular biology of the cell.
[20] N. C. Price,et al. Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. , 2003, The Biochemical journal.
[21] Danish Sayed,et al. An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. , 2010, Cellular signalling.
[22] Michael M. Murphy,et al. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. , 2005, Cell metabolism.
[23] Izumi Horikawa,et al. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. , 2005, Molecular biology of the cell.
[24] K. Walsh. Akt signaling and growth of the heart. , 2006, Circulation.
[25] Anthony J. Muslin,et al. Akt1 Is Required for Physiological Cardiac Growth , 2006, Circulation.
[26] F. Alt,et al. SIRT1 controls endothelial angiogenic functions during vascular growth. , 2007, Genes & development.
[27] K. Shimamoto,et al. Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1* , 2007, Journal of Biological Chemistry.
[28] S. Samant,et al. Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression. , 2008, American journal of physiology. Heart and circulatory physiology.
[29] M. Kaeberlein. The ongoing saga of sirtuins and aging. , 2008, Cell metabolism.
[30] V. Longo,et al. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. , 2008, Cell metabolism.
[31] M. Rebecchi,et al. Pleckstrin homology domains: a common fold with diverse functions. , 1998, Annual review of biophysics and biomolecular structure.
[32] S. Vatner,et al. Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes , 2009, Circulation research.
[33] Amy V. Lynch,et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes , 2007, Nature.
[34] W. Hahn,et al. The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth , 2008, PloS one.
[35] F. McCormick,et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. , 1998, Science.
[36] K. Birukov,et al. SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1 , 2009, Molecular and Cellular Biology.
[37] Gene Kim,et al. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. , 2009, The Journal of clinical investigation.
[38] D. Su,et al. Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy. , 2009, Canadian journal of physiology and pharmacology.
[39] Spyro Mousses,et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer , 2007, Nature.
[40] Alfonso Bellacosa,et al. AKT plays a central role in tumorigenesis , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[41] L. Guarente,et al. Calorie restriction, SIRT1 and metabolism: understanding longevity , 2005, Nature Reviews Molecular Cell Biology.
[42] Stephen H. Smith,et al. HDAC4 and PCAF Bind to Cardiac Sarcomeres and Play a Role in Regulating Myofilament Contractile Activity* , 2008, Journal of Biological Chemistry.
[43] Yu Wang,et al. SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells , 2010, Circulation research.
[44] Alexander S Banks,et al. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. , 2008, Cell metabolism.
[45] Xin Lin,et al. The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation , 2009, Science.
[46] S. Cook,et al. Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart* , 2002, The Journal of Biological Chemistry.
[47] Qing Xu,et al. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. , 2009, Cell metabolism.
[48] S. Vatner,et al. Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart , 2007, Circulation research.
[49] Maria Deak,et al. High-Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate , 2002, Current Biology.
[50] Joseph A. Baur,et al. Therapeutic potential of resveratrol: the in vivo evidence , 2006, Nature Reviews Drug Discovery.
[51] Yiling Lu,et al. Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery , 2005, Nature Reviews Drug Discovery.
[52] T. Malek,et al. Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. , 2010, The Journal of clinical investigation.
[53] C. Deng,et al. Recent progress in the biology and physiology of sirtuins , 2009, Nature.
[54] Steven P. Gygi,et al. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase , 2004, Science.