Study on antidepressant activity of chiisanoside in mice

&NA; The antidepressant‐like effect of chiisanoside from the leaves of Acanthopanax sessiliflorus was evaluated by using mice models of depression, forced swim test (FST) and tail suspension test (TST). The results showed that treatment with chiisanoside at dose of 5.0 mg/kg significantly decreased immobility time in the FST and TST. Pretreatment with haloperidol (a non‐selective D2 receptor antagonist), bicuculline (a competitive GABA antagonist) and N‐methyl‐D‐aspartic acid (NMDA, an agonist at the glutamate site) effectively reversed the antidepressant‐like effect of chiisanoside (5.0 mg/kg). Moreover, chiisanoside treatment did not change the locomotor activity. And chiisanoside (5.0 mg/kg) also effectively increased the dopamine (DA) and &ggr;‐aminobutyric acid (GABA) levels in mice brains exposed to the FST and TST in the co‐treatment groups. Then we designed lipopolysaccharide (LPS)‐induced antidepressant behavioral experiment, the results showed that LPS significantly increased immobility duration in the TST and FST. Chiisanoside administration could effectively reduce serum interleukin‐6 (IL‐6) and tumor necrosis factor‐&agr; (TNF‐&agr;) levels; at the same time, the changes of related indexes of oxidative stress are improved, such as superoxide dismutase (SOD) and malondialdehyde (MDA). Moreover, chiisanoside effectively down‐regulated brain‐derived neurotrophic factor (BDNF), tropomyosin‐related kinase B (TrkB) and nuclear factor‐&kgr;B (NF‐&kgr;B) in hippocampal. In conclusion, chiisanoside displayed significant antidepressant‐like effect, which was probably related to the DAergic, GABAergic and glutamatergic systems. And the mechanism of anti‐depressant effect of chiisanoside might be via the alterations of animal behaviors, hippocampus inflammation, oxidative stress and neurotrophy, which might be attributed by the BDNF/TrkB/NF‐&kgr;B pathway. HighlightsChiisanoside, a triterpenoid saponin extracted from Acanthopanax sessiliflorus, may have antidepressant activity.The antidepressant effect of chiisanoside may be associated with GABAergic, dopaminergic and glutamatergic systems.The mechanism of the action of chiisanoside may be attributed to the BDNF/TrkB/NF‐&kgr;B signaling pathways.

[1]  Kyung-Tae Lee,et al.  Antiinflammatory effects of chiisanoside and chiisanogenin obtained from the leaves of Acanthopanax chiisanensis in the carrageenan- and Freund's complete adjuvant-induced rats. , 2005, Journal of ethnopharmacology.

[2]  Jingfeng Wang,et al.  Renoprotective effect of fucoidan from Acaudina molpadioides in streptozotocin/high fat diet-induced type 2 diabetic mice , 2017 .

[3]  Ying Yang,et al.  Salidroside ameliorates arthritis-induced brain cognition deficits by regulating Rho/ROCK/NF-κB pathway , 2016, Neuropharmacology.

[4]  Lingpeng Zhu,et al.  Salidroside attenuates lipopolysaccharide (LPS) induced serum cytokines and depressive-like behavior in mice , 2015, Neuroscience Letters.

[5]  B. Thierry,et al.  The tail suspension test: A new method for screening antidepressants in mice , 2004, Psychopharmacology.

[6]  C. Nemeroff,et al.  The role of dopamine in the pathophysiology of depression. , 2007, Archives of general psychiatry.

[7]  Wenjiao Jiang,et al.  Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho Signaling , 2015, Inflammation.

[8]  장윤희,et al.  Y. , 2003, Industrial and Labor Relations Terms.

[9]  Reidun Ursin,et al.  Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats. A microdialysis study in an animal model of depression , 2007, Behavioural Brain Research.

[10]  Y. Hurd,et al.  D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain , 2001, Journal of Chemical Neuroanatomy.

[11]  Michel Bourin,et al.  Dopamine, depression and antidepressants , 2004, Fundamental & clinical pharmacology.

[12]  M. Molina-hernandez,et al.  Synergistic interaction between ketoconazole and several antidepressant drugs with allopregnanolone treatments in ovariectomized Wistar rats forced to swim , 2004, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[13]  Wenjiao Jiang,et al.  Magnesium Isoglycyrrhizinate attenuates lipopolysaccharide-induced depressive-like behavior in mice. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  C. Correll,et al.  Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder , 2015, World psychiatry : official journal of the World Psychiatric Association.

[15]  Jiangna Li,et al.  [The interaction between gamma-aminobutyric acid and other related neurotransmitters in depression]. , 2014, Sheng li ke xue jin zhan [Progress in physiology].

[16]  Feixong Chen,et al.  Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress , 2014, European Neuropsychopharmacology.

[17]  Olga V. Demler,et al.  The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). , 2003, JAMA.

[18]  이화영.  X , 1960, Chinese Plants Names Index 2000-2009.

[19]  K. Oh,et al.  Antibacterial compounds from the leaves ofAcanthopanax senticosus , 2003, Archives of pharmacal research.

[20]  Zhen Yan,et al.  The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission , 2011, Nature Reviews Neuroscience.

[21]  R. Porsolt,et al.  Behavioral despair in mice: a primary screening test for antidepressants. , 1977, Archives internationales de pharmacodynamie et de therapie.

[22]  Jinping Liu,et al.  Chiisanoside, a triterpenoid saponin, exhibits anti-tumor activity by promoting apoptosis and inhibiting angiogenesis , 2017 .

[23]  Mahshid S. Hosseini-Zare,et al.  Effects of experimental traumatic brain injury and impaired glutamate transport on cortical spreading depression , 2017, Experimental Neurology.

[24]  Wei Jiang,et al.  Fucoidan from sea cucumber may improve hepatic inflammatory response and insulin resistance in mice. , 2016, International immunopharmacology.

[25]  M. Lemke.  Dopamine agonists in the treatment of non‐motor symptoms of Parkinson’s disease: depression , 2008, European journal of neurology.

[26]  F. Nicoletti,et al.  Anxiety-Like Behavior of Prenatally Stressed Rats Is Associated with a Selective Reduction of Glutamate Release in the Ventral Hippocampus , 2012, The Journal of Neuroscience.

[27]  G. Vaiva,et al.  Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder , 2004, Biological Psychiatry.

[28]  J. Koenderink.  Q… , 2014, Les noms officiels des communes de Wallonie, de Bruxelles-Capitale et de la communaute germanophone.

[29]  R. Shelton,et al.  Oxidative stress and glutathione response in tissue cultures from persons with major depression. , 2012, Journal of psychiatric research.

[30]  Xiaohan Yang,et al.  Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression , 2017, Behavioural Brain Research.

[31]  Fabio Benfenati,et al.  Acute Stress Increases Depolarization-Evoked Glutamate Release in the Rat Prefrontal/Frontal Cortex: The Dampening Action of Antidepressants , 2010, PloS one.

[32]  J. Duan,et al.  Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice , 2016, Psychiatry Research.

[33]  K. Burdick,et al.  Cognitive side effects of anticonvulsants. , 2001, The Journal of clinical psychiatry.

[34]  Miss A.O. Penney.  (b) , 1974, The New Yale Book of Quotations.

[35]  A. Lorenzo,et al.  Antioxidants as Antidepressants , 2012, CNS Drugs.

[36]  M. Popoli,et al.  The Action of Antidepressants on the Glutamate System: Regulation of Glutamate Release and Glutamate Receptors , 2013, Biological Psychiatry.

[37]  D. Kim,et al.  Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities. , 2001, Biological & pharmaceutical bulletin.

[38]  Dae-Young Lee,et al.  Bioactive 3,4-seco-Triterpenoids from the Fruits of Acanthopanax sessiliflorus. , 2012, Journal of natural products.

[39]  K. S. Al-Harbi.  Treatment-resistant depression: therapeutic trends, challenges, and future directions , 2012, Patient preference and adherence.

[40]  Gunnar Mau,et al.  Noradrenergic blockade and memory in patients with major depression and healthy participants , 2014, Psychoneuroendocrinology.

[41]  Min Sun,et al.  Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress , 2016, Translational psychiatry.

[42]  Michael Maes,et al.  Evidence for an immune response in major depression: A review and hypothesis , 1995, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[43]  E. Nestler,et al.  From synapse to nucleus: Novel targets for treating depression , 2010, Neuropharmacology.

[44]  Xue-jun Li,et al.  Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats , 2005, Pharmacology Biochemistry and Behavior.

[45]  A. Rodrigues,et al.  Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice , 2014, Pharmacology Biochemistry and Behavior.

[46]  M. Popoli,et al.  Synergistic mechanisms involved in the antidepressant effects of agomelatine , 2012, European Neuropsychopharmacology.

[47]  Gorjan Alagic,et al.  #p , 2019, Quantum information & computation.

[48]  Carlos A. Zarate,et al.  Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders , 2008, Nature Reviews Drug Discovery.

[49]  F. Petty,et al.  Neurochemical basis of the action of antidepressants on learned helplessness. , 1980, Behavioral and neural biology.

[50]  Cüneyt Ünsal,et al.  The change in plasma GABA, glutamine and glutamate levels in fluoxetine- or S-citalopram-treated female patients with major depression , 2009, European Journal of Clinical Pharmacology.

[51]  J. Sapa,et al.  The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect , 2017, Pharmacological reports : PR.

[52]  Sanghyun Lee,et al.  Platelet anti-aggregating triterpenoids from the leaves of Acanthopanax senticosus and the fruits of A. sessiliflorus. , 2004, Planta medica.

[53]  M. Furey,et al.  Replication of Scopolamine's Antidepressant Efficacy in Major Depressive Disorder: A Randomized, Placebo-Controlled Clinical Trial , 2010, Biological Psychiatry.

[54]  Mengjie Xu,et al.  The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice. , 2016, Food & function.

[55]  Tsuyoshi Murata,et al.  {m , 1934, ACML.

[56]  Dong Gu Lee,et al.  Protective effects of 3,4-seco-lupane type triterpenes from Acanthopanax senticosus against advanced glycation endproducts , 2012, Horticulture, Environment, and Biotechnology.

[57]  吉積 一真.  Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents , 2008 .

[58]  G. Nowak,et al.  NMDA antagonists under investigation for the treatment of major depressive disorder , 2014, Expert opinion on investigational drugs.

[59]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[60]  G. Aghajanian,et al.  Synaptic Dysfunction in Depression: Potential Therapeutic Targets , 2012, Science.

[61]  Hiroshi Nagase,et al.  Effects of diabetes on spontaneous locomotor activity in mice , 1994, Neuroscience Letters.