Spectrophotometric multicomponent resolution of a veterinary formulation containing oxfendazole and oxyclozanide by multivariate calibration-prediction techniques.

Four multivariate calibration-prediction techniques, classical least-squares, inverse least-squares, principal component regression and partial least-squares regression were applied to the spectrophotometric multicomponent analysis of a veterinary formulation containing oxfendazole (OXF) and oxyclozanide (OXC) without any separation step. The multivariate calibrations were constructed by measuring the absorbance values at 14 points in the 285-350 nm wavelength range and by using the training set of standard mixtures containing OXF and OXC in the different compositions. The validity of building multivariate calibrations was checked by using the synthetic mixtures of both drugs. The multivariate calibration models were successfully applied to the spectrophotometric determination of OXF and OXC in laboratory prepared mixtures and a veterinary formulation. The results obtained were statistically compared with each other.

[1]  R D Bautista,et al.  Simultaneous spectrophotometric determination of drugs in pharmaceutical preparations using multiple linear regression and partial least-squares regression, calibration and prediction methods. , 1996, Talanta.

[2]  F. Jiménez,et al.  Evaluation of multicomponent kinetic analysis data by a partial least squares calibration method , 1993 .

[3]  A. R. Long,et al.  Matrix solid phase dispersion (MSPD) extraction and liquid chromatographic determination of five benzimidazole anthelmintics in pork muscle tissue , 1990 .

[4]  R. Tijssen,et al.  Theoretical aspects and practical potentials of rapid gas analysis in capillary gas chromatography , 1987 .

[5]  D. Baleanu,et al.  Spectrophotometric multicomponent analysis of a mixture of metamizol, acetaminophen and caffeine in pharmaceutical formulations by two chemometric techniques. , 2001, Journal of pharmaceutical and biomedical analysis.

[6]  Wolfhard Wegscheider,et al.  Spectrophotometric multicomponent analysis applied to trace metal determinations , 1985 .

[7]  A. G. Frenich,et al.  Comparison of Multicomponent Determination of Iprodione, Procymidone and Chlorothalonil by Partial Least Squares Modelling Using Spectrophotometric and High-Performance Liquid Chromatography Data , 1997 .

[8]  A R Khan,et al.  LC assay method for oxfendazole and oxyclozanide in pharmaceutical preparation. , 2000, Journal of pharmaceutical and biomedical analysis.

[9]  Richard Kramer,et al.  Chemometric Techniques For Quantitative Analysis , 1998 .

[10]  James W. McNicol,et al.  A designed experiment for the examination of techniques used in the analysis of near-infrared spectra. Part 2. Derivation and testing of regression models , 1985 .

[11]  G. Jasso.  Review of "International Encyclopedia of Statistical Sciences, edited by Samuel Kotz, Norman L. Johnson, and Campbell B. Read, New York, Wiley, 1982-1988" , 1989 .

[12]  Q. Mckellar,et al.  A high performance liquid chromatographic method for the determination of febantel and its major metabolites in lamb plasma. , 1993, Biomedical chromatography : BMC.

[13]  J. Vílchez,et al.  Resolution of phenol, o-cresol, m-cresol and p-cresol mixtures by excitation fluorescence using partial least-squares (PLS) multivariate calibration , 1996 .

[14]  A. M. Martí,et al.  Determination of benzimidazole anthelmintics in meat samples. , 1990, Journal of chromatography.

[15]  Kenneth R. Beebe,et al.  An introduction to multivariate calibration and analysis , 1987 .

[16]  J. Gani,et al.  Perspectives in Probability and Statistics. , 1980 .

[17]  Erdal Dinç,et al.  Comparative study of the ratio spectra derivative spectrophotometry, derivative spectrophotometry and Vierordt's method applied to the analysis of oxfendazole and oxyclozanide in a veterinary formulation , 1997 .

[18]  Juana Rodríguez,et al.  Partial least squares method in the analysis by square wave voltammetry. Simultaneous determination of sulphamethoxypyridazine and trimethoprim , 1997 .

[19]  D. Baleanu,et al.  CHEMOMETRIC QUANTITATIVE ANALYSIS OF PYRIDOXINE HCl AND THIAMINE HCl IN A VITAMIN COMBINATION BY PRINCIPAL COMPONENT ANALYSIS, CLASSICAL LEAST SQUARES, AND INVERSE LEAST SQUARES TECHNIQUES , 2001 .