Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation

Tyrosine kinases indirectly raise intracellular calcium concentration ([Ca2+]i) by activating phospholipases that generate inositol 1,4,5-trisphosphate (IP3). IP3 activates the IP3 receptor (IP3R), an intracellular calcium release channel on the endoplasmic reticulum. T cell receptor stimulation triggered a physical association between the nonreceptor protein tyrosine kinase Fyn and the IP3R, which induced tyrosine phosphorylation of the IP3R. Fyn activated an IP3-gated calcium channel in vitro, and tyrosine phosphorylation of the IP3R during T cell activation was reduced in thymocytes from fyn−/− mice. Thus, activation of the IP3R by tyrosine phosphorylation may play a role in regulating [Ca2+]i.

[1]  A. Marks,et al.  The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[2]  A. Marks,et al.  The Human Type 1 Inositol 1,4,5-Trisphosphate Receptor from T Lymphocytes , 1995, The Journal of Biological Chemistry.

[3]  I. Bezprozvanny,et al.  Inositol (1,4,5)-trisphosphate (InsP3)-gated Ca channels from cerebellum: conduction properties for divalent cations and regulation by intraluminal calcium , 1994, The Journal of general physiology.

[4]  T. Lincoln,et al.  Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. , 1994, The Journal of biological chemistry.

[5]  K.,et al.  Cyclic AMP-dependent phosphorylation of an immunoaffinity-purified homotetrameric inositol 1,4,5-trisphosphate receptor (type I) increases Ca2+ flux in reconstituted lipid vesicles. , 1994, The Journal of biological chemistry.

[6]  Dan R. Littman,et al.  Signal transduction by lymphocyte antigen receptors , 1994, Cell.

[7]  K. Mikoshiba,et al.  Transmembrane topology and sites of N-glycosylation of inositol 1,4,5-trisphosphate receptor. , 1993, The Journal of biological chemistry.

[8]  I. Bezprozvanny,et al.  ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites , 1993, Neuron.

[9]  S. Snyder,et al.  Inositol 1,4,5-trisphosphate receptors: labeling the inositol 1,4,5-trisphosphate binding site with photoaffinity ligands. , 1993, Biochemistry.

[10]  E. Kandel,et al.  Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. , 1992, Science.

[11]  P. Stein,et al.  pp59 fyn mutant mice display differential signaling in thymocytes and peripheral T cells , 1992, Cell.

[12]  R. Perlmutter,et al.  Defective T cell receptor signaling in mice lacking the thymic isoform of p59 fyn , 1992, Cell.

[13]  S. Snyder,et al.  IP3 receptor: localization to plasma membrane of T cells and cocapping with the T cell receptor. , 1992, Science.

[14]  S. Snyder,et al.  Autophosphorylation of inositol 1,4,5-trisphosphate receptors. , 1992, The Journal of biological chemistry.

[15]  I. Bezprozvanny,et al.  Inositol 1,4,5-trisphosphate-gated channels in cerebellum: presence of multiple conductance states , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[16]  James Watras,et al.  Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum , 1991, Nature.

[17]  K. M. Abraham,et al.  Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59 fyn ) , 1991, Cell.

[18]  R. Huganir,et al.  Inositol trisphosphate receptor: phosphorylation by protein kinase C and calcium calmodulin-dependent protein kinases in reconstituted lipid vesicles. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[19]  R. Huganir,et al.  Inositol 1,4,5-trisphosphate receptor is phosphorylated by cyclic AMP-dependent protein kinase at serines 1755 and 1589. , 1991, Biochemical and biophysical research communications.

[20]  T. Südhof,et al.  The ligand binding site and transduction mechanism in the inositol‐1,4,5‐triphosphate receptor. , 1990, The EMBO journal.

[21]  G. Mills,et al.  Tyrosine phosphorylation is an obligatory event in IL-2 secretion. , 1990, Journal of immunology.

[22]  G. Schieven,et al.  Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[23]  R. Klausner,et al.  Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[24]  T. Mustelin,et al.  T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. , 1990, Science.

[25]  Teiichi Furuichi,et al.  Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400 , 1989, Nature.