In situ nuclear DNA methylation in dilated cardiomyopathy: an endomyocardial biopsy study

Although distinct DNA methylation patterns have been reported, its localization and roles remain to be defined in heart failure. We investigated the cellular and subcellular localization of DNA methylation and its pathophysiological significance in human failing hearts.

[1]  L. Mestroni,et al.  Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy , 2019, Circulation research.

[2]  D. Phelan,et al.  Targeted DNA Methylation Profiling of Human Cardiac Tissue Reveals Novel Epigenetic Traits and Gene Deregulation Across Different Heart Failure Patient Subtypes , 2019, Circulation. Heart failure.

[3]  Douglas J. Chapski,et al.  Epigenomes in Cardiovascular Disease , 2018, Circulation research.

[4]  Karen S. Frese,et al.  Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure , 2017, Circulation.

[5]  R. Backofen,et al.  Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo , 2017, Nature Communications.

[6]  C. Vecchione,et al.  A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling , 2017, Oxidative medicine and cellular longevity.

[7]  Bas van Steensel,et al.  Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression , 2017, Cell.

[8]  P. Sham,et al.  Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor , 2016, Circulation.

[9]  T. Gillette,et al.  Epigenetic regulation in heart failure , 2016, Current opinion in cardiology.

[10]  Christoph D. Rau,et al.  DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. , 2016, Circulation research.

[11]  C. Watson,et al.  Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis , 2016, Journal of cardiovascular pharmacology and therapeutics.

[12]  R. Foisner,et al.  Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation. , 2015, Annual review of biochemistry.

[13]  A. El-Osta,et al.  HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes , 2015, Epigenetics.

[14]  J. Marín-García,et al.  Epigenetics of the failing heart , 2015, Heart Failure Reviews.

[15]  A. El-Osta,et al.  Chromatin modifications remodel cardiac gene expression. , 2014, Cardiovascular research.

[16]  D. Phelan,et al.  Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype. , 2014, Human molecular genetics.

[17]  Lubo Zhang,et al.  Inhibition of DNA methylation reverses norepinephrine-induced cardiac hypertrophy in rats. , 2014, Cardiovascular research.

[18]  L. D. de Windt,et al.  Regulation of fetal gene expression in heart failure. , 2013, Biochimica et biophysica acta.

[19]  Eva K. Lee,et al.  Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis. , 2013, Physiological genomics.

[20]  Yu-yu Yao,et al.  Transforming Growth Factor β1 Induces the Expression of Collagen Type I by DNA Methylation in Cardiac Fibroblasts , 2013, PloS one.

[21]  Benjamin Meder,et al.  Alterations in cardiac DNA methylation in human dilated cardiomyopathy , 2013, EMBO molecular medicine.

[22]  Q. Bian,et al.  Revisiting higher-order and large-scale chromatin organization. , 2012, Current opinion in cell biology.

[23]  Mehregan Movassagh,et al.  Genome-wide DNA methylation in human heart failure. , 2011, Epigenomics.

[24]  Thomas K Borg,et al.  Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse. , 2007, American journal of physiology. Heart and circulatory physiology.

[25]  G. Takemura,et al.  Nuclear hypertrophy reflects increased biosynthetic activities in myocytes of human hypertrophic hearts. , 2006, Circulation journal : official journal of the Japanese Circulation Society.

[26]  R. Irizarry,et al.  Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure. , 2005, Physiological genomics.

[27]  P. Armstrong,et al.  Remodeling and reparation of the cardiovascular system. , 1992, Journal of the American College of Cardiology.

[28]  M. Matsuda,et al.  Ventricular expression of atrial natriuretic polypeptide and its relations with hemodynamics and histology in dilated human hearts. Immunohistochemical study of the endomyocardial biopsy specimens. , 1989, Circulation.

[29]  E. Olsen,et al.  Electron Microscopic Investigation of Endomyocardial Biopsy Samples in Hypertrophy and Cardiomyopathy: A Semiquantitative Study in 48 Patients , 1981, Circulation.

[30]  C. Kawai,et al.  Report of the WHO/ISFC task force on the definition and classification of cardiomyopathies. , 1980, British heart journal.

[31]  Nag Ac,et al.  Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution. , 1980 .

[32]  A. Nag,et al.  Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution. , 1980, Cytobios.

[33]  E. Olsen,et al.  The Myocardium , 1976 .

[34]  E. Olsen.  Structural and ultrastructural basis of myocardial disease. , 1976, Proceedings of the Royal Society of Medicine.

[35]  G. Breithardt,et al.  Die Bedeutung der endomyokardialen Katheterbiopsie für die Diagnostik und die Beurteilung der Prognose der kongestiven Kardiomyopathie , 1975 .